In Vivo Evaluation of –Based Indian Traditional Formulation (), Against Chikungunya Virus–Induced Morbidity and Arthralgia
Chikungunya viral fever results in extreme morbidity and arthralgia in affected individuals. Currently, modern medicines providing symptomatic relief for the acute febrile phase and the chronic arthritic phase are only options available. Traditional Indian medical system, however, uses specific form...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-02-01
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| Series: | Journal of Evidence-Based Integrative Medicine |
| Online Access: | https://doi.org/10.1177/2156587218757661 |
| _version_ | 1819175956605042688 |
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| author | Jaspreet Jain MSc Vimal Narayanan BSMS, MSc Shivam Chaturvedi MVSc Somnath Pai PhD Sujatha Sunil PhD |
| author_facet | Jaspreet Jain MSc Vimal Narayanan BSMS, MSc Shivam Chaturvedi MVSc Somnath Pai PhD Sujatha Sunil PhD |
| author_sort | Jaspreet Jain MSc |
| collection | DOAJ |
| description | Chikungunya viral fever results in extreme morbidity and arthralgia in affected individuals. Currently, modern medicines providing symptomatic relief for the acute febrile phase and the chronic arthritic phase are only options available. Traditional Indian medical system, however, uses specific formulations for treatment of this infection; one such polyherbal formulation used to treat the postpyretic phase of chikungunya is amukkara choornam . The current study was undertaken to study the efficacy of amukkara choornam in the treatment of chikungunya in C57BL/6J mice. The formulation when administered to chikungunya-infected mice relieved morbidity and joint swelling. Analysis of virus clearance in brain and joint tissues on formulation treatment revealed a direct correlation of viral load in brain to morbidity during infection; likewise, joint swelling receded prior to complete viral clearance explaining possible immunomodulatory effect of amukkara choornam. This study provides insight into the possible mode of action of amukkara choornam during chikungunya. |
| first_indexed | 2024-12-22T21:03:06Z |
| format | Article |
| id | doaj.art-6ae4411b008a4d3eafb2e1686ac2e94a |
| institution | Directory Open Access Journal |
| issn | 2515-690X |
| language | English |
| last_indexed | 2024-12-22T21:03:06Z |
| publishDate | 2018-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Evidence-Based Integrative Medicine |
| spelling | doaj.art-6ae4411b008a4d3eafb2e1686ac2e94a2022-12-21T18:12:47ZengSAGE PublishingJournal of Evidence-Based Integrative Medicine2515-690X2018-02-012310.1177/2156587218757661In Vivo Evaluation of –Based Indian Traditional Formulation (), Against Chikungunya Virus–Induced Morbidity and ArthralgiaJaspreet Jain MSc0Vimal Narayanan BSMS, MSc1Shivam Chaturvedi MVSc2Somnath Pai PhD3Sujatha Sunil PhD4 International Centre for Genetic Engineering and Biotechnology, New Delhi, India International Centre for Genetic Engineering and Biotechnology, New Delhi, India International Centre for Genetic Engineering and Biotechnology, New Delhi, India Amity University, Noida, Uttar Pradesh, India International Centre for Genetic Engineering and Biotechnology, New Delhi, IndiaChikungunya viral fever results in extreme morbidity and arthralgia in affected individuals. Currently, modern medicines providing symptomatic relief for the acute febrile phase and the chronic arthritic phase are only options available. Traditional Indian medical system, however, uses specific formulations for treatment of this infection; one such polyherbal formulation used to treat the postpyretic phase of chikungunya is amukkara choornam . The current study was undertaken to study the efficacy of amukkara choornam in the treatment of chikungunya in C57BL/6J mice. The formulation when administered to chikungunya-infected mice relieved morbidity and joint swelling. Analysis of virus clearance in brain and joint tissues on formulation treatment revealed a direct correlation of viral load in brain to morbidity during infection; likewise, joint swelling receded prior to complete viral clearance explaining possible immunomodulatory effect of amukkara choornam. This study provides insight into the possible mode of action of amukkara choornam during chikungunya.https://doi.org/10.1177/2156587218757661 |
| spellingShingle | Jaspreet Jain MSc Vimal Narayanan BSMS, MSc Shivam Chaturvedi MVSc Somnath Pai PhD Sujatha Sunil PhD In Vivo Evaluation of –Based Indian Traditional Formulation (), Against Chikungunya Virus–Induced Morbidity and Arthralgia Journal of Evidence-Based Integrative Medicine |
| title | In Vivo Evaluation of –Based Indian Traditional Formulation (), Against Chikungunya Virus–Induced Morbidity and Arthralgia |
| title_full | In Vivo Evaluation of –Based Indian Traditional Formulation (), Against Chikungunya Virus–Induced Morbidity and Arthralgia |
| title_fullStr | In Vivo Evaluation of –Based Indian Traditional Formulation (), Against Chikungunya Virus–Induced Morbidity and Arthralgia |
| title_full_unstemmed | In Vivo Evaluation of –Based Indian Traditional Formulation (), Against Chikungunya Virus–Induced Morbidity and Arthralgia |
| title_short | In Vivo Evaluation of –Based Indian Traditional Formulation (), Against Chikungunya Virus–Induced Morbidity and Arthralgia |
| title_sort | in vivo evaluation of based indian traditional formulation against chikungunya virus induced morbidity and arthralgia |
| url | https://doi.org/10.1177/2156587218757661 |
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