Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides
Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources. Based on the number of rings and conjugation systems on the backbone, it can be further categorized into three types A, B, and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/10/6/246 |
| _version_ | 1797565300590247936 |
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| author | Yaojie Guo Jens C. Frisvad Thomas O. Larsen |
| author_facet | Yaojie Guo Jens C. Frisvad Thomas O. Larsen |
| author_sort | Yaojie Guo |
| collection | DOAJ |
| description | Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources. Based on the number of rings and conjugation systems on the backbone, it can be further categorized into three types A, B, and C. These compounds have been applied to various bioassays, and some have exhibited promising bioactivities like antifungal activity against phytopathogenic fungi and transcriptional activation on liver X receptor α. This review summarizes all the research related to natural OPK NRPs, including their biological sources, chemical structures, bioassays, as well as proposed biosynthetic mechanisms from 1988 to March 2020. The taxonomy of the fungal sources and chirality-related issues of these products are also discussed. |
| first_indexed | 2024-03-10T19:10:10Z |
| format | Article |
| id | doaj.art-6ae4ac4764e241e395217ce13bddbc61 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T19:10:10Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-6ae4ac4764e241e395217ce13bddbc612023-11-20T03:52:59ZengMDPI AGMetabolites2218-19892020-06-0110624610.3390/metabo10060246Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal PeptidesYaojie Guo0Jens C. Frisvad1Thomas O. Larsen2Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, Building 221, DK-2800 Kgs. Lyngby, DenmarkDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, Building 221, DK-2800 Kgs. Lyngby, DenmarkDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, Building 221, DK-2800 Kgs. Lyngby, DenmarkRecently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources. Based on the number of rings and conjugation systems on the backbone, it can be further categorized into three types A, B, and C. These compounds have been applied to various bioassays, and some have exhibited promising bioactivities like antifungal activity against phytopathogenic fungi and transcriptional activation on liver X receptor α. This review summarizes all the research related to natural OPK NRPs, including their biological sources, chemical structures, bioassays, as well as proposed biosynthetic mechanisms from 1988 to March 2020. The taxonomy of the fungal sources and chirality-related issues of these products are also discussed.https://www.mdpi.com/2218-1989/10/6/246oxepinenonribosomal peptidesbioactivitybiosynthesisfungi<i>Aspergillus</i> |
| spellingShingle | Yaojie Guo Jens C. Frisvad Thomas O. Larsen Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides Metabolites oxepine nonribosomal peptides bioactivity biosynthesis fungi <i>Aspergillus</i> |
| title | Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides |
| title_full | Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides |
| title_fullStr | Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides |
| title_full_unstemmed | Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides |
| title_short | Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides |
| title_sort | review of oxepine pyrimidinone ketopiperazine type nonribosomal peptides |
| topic | oxepine nonribosomal peptides bioactivity biosynthesis fungi <i>Aspergillus</i> |
| url | https://www.mdpi.com/2218-1989/10/6/246 |
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