Suppressing Kaposi’s Sarcoma-Associated Herpesvirus Lytic Gene Expression and Replication by RNase P Ribozyme

Suppressing Kaposi’s Sarcoma-Associated Herpesvirus Lytic Gene Expression and Replication by RNase P Ribozyme

Kaposi’s sarcoma, an AIDS-defining illness, is caused by Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic virus. In this study, we engineered ribozymes derived from ribonuclease P (RNase P) catalytic RNA with targeting against the mRNA encoding KSHV immediate early replication and transc...

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Bibliographic Details
Main Authors: Yujun Liu, Yuan-Chuan Chen, Bin Yan, Fenyong Liu
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
Kaposi sarcoma-associated herpesvirus
herpesvirus
antiviral
gene therapy
RNase P
ribozyme
Online Access:https://www.mdpi.com/1420-3049/28/8/3619

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