Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment

Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment

Abstract Background Purinergic P2Y1 and P2Y12 receptors (P2Y1-R and P2Y12-R) are G protein-coupled receptors (GPCR) activated by adenosine diphosphate (ADP) to mediate platelet activation, thereby playing a pivotal role in hemostasis and thrombosis. While P2Y12-R is the major target of antiplatelet...

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Bibliographic Details
Main Authors: Agnès Ribes, Cédric Garcia, Marie-Pierre Gratacap, Evi Kostenis, Laurent O. Martinez, Bernard Payrastre, Jean-Michel Sénard, Céline Galés, Véronique Pons
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Biology
Subjects:
GPCR
Constitutive signaling
Inverse agonism
MRS2179
P2Y receptor
Online Access:https://doi.org/10.1186/s12915-023-01528-y

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