Ambient Temperature and Cerebrovascular Hemodynamics in the Elderly.
BACKGROUND AND PURPOSE:Some prior studies have linked ambient temperature with risk of cerebrovascular events. If causal, the pathophysiologic mechanisms underlying this putative association remain unknown. Temperature-related changes in cerebral vascular function may play a role, but this hypothesi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4721538?pdf=render |
| _version_ | 1818236678049890304 |
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| author | Wen-Chi Pan Melissa N Eliot Petros Koutrakis Brent A Coull Farzaneh A Sorond Gregory A Wellenius |
| author_facet | Wen-Chi Pan Melissa N Eliot Petros Koutrakis Brent A Coull Farzaneh A Sorond Gregory A Wellenius |
| author_sort | Wen-Chi Pan |
| collection | DOAJ |
| description | BACKGROUND AND PURPOSE:Some prior studies have linked ambient temperature with risk of cerebrovascular events. If causal, the pathophysiologic mechanisms underlying this putative association remain unknown. Temperature-related changes in cerebral vascular function may play a role, but this hypothesis has not been previously evaluated. METHODS:We evaluated the association between ambient temperature and cerebral vascular function among 432 participants ≥65 years old from the MOBILIZE Boston Study with data on cerebrovascular blood flow, cerebrovascular resistance, and cerebrovascular reactivity in the middle cerebral artery. We used linear regression models to assess the association of mean ambient temperature in the previous 1 to 28 days with cerebrovascular hemodynamics adjusting for potential confounding factors. RESULTS:A 10°C increase in the 21-day moving average of ambient temperature was associated with a 10.1% (95% confidence interval [CI], 2.2%, 17.3%) lower blood flow velocity, a 9.0% (95% CI, 0.7%, 18.0%) higher cerebrovascular resistance, and a 15.3% (95%CI, 2.7%, 26.4%) lower cerebral vasoreactivity. Further adjustment for ozone and fine particulate matter (PM2.5) did not materially alter the results. However, we found statistically significant interactions between ambient temperature and PM2.5 such that the association between temperature and blood flow velocity was attenuated at higher levels of PM2.5. CONCLUSIONS:In this elderly population, we found that ambient temperature was negatively associated with cerebral blood flow velocity and cerebrovascular vasoreactivity and positively associated with cerebrovascular resistance. Changes in vascular function may partly underlie the observed associations between ambient temperature and risk of cerebrovascular events. |
| first_indexed | 2024-12-12T12:13:40Z |
| format | Article |
| id | doaj.art-6ae89de496e0424d9bee65f9c918a360 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T12:13:40Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6ae89de496e0424d9bee65f9c918a3602022-12-22T00:24:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01108e013403410.1371/journal.pone.0134034Ambient Temperature and Cerebrovascular Hemodynamics in the Elderly.Wen-Chi PanMelissa N EliotPetros KoutrakisBrent A CoullFarzaneh A SorondGregory A WelleniusBACKGROUND AND PURPOSE:Some prior studies have linked ambient temperature with risk of cerebrovascular events. If causal, the pathophysiologic mechanisms underlying this putative association remain unknown. Temperature-related changes in cerebral vascular function may play a role, but this hypothesis has not been previously evaluated. METHODS:We evaluated the association between ambient temperature and cerebral vascular function among 432 participants ≥65 years old from the MOBILIZE Boston Study with data on cerebrovascular blood flow, cerebrovascular resistance, and cerebrovascular reactivity in the middle cerebral artery. We used linear regression models to assess the association of mean ambient temperature in the previous 1 to 28 days with cerebrovascular hemodynamics adjusting for potential confounding factors. RESULTS:A 10°C increase in the 21-day moving average of ambient temperature was associated with a 10.1% (95% confidence interval [CI], 2.2%, 17.3%) lower blood flow velocity, a 9.0% (95% CI, 0.7%, 18.0%) higher cerebrovascular resistance, and a 15.3% (95%CI, 2.7%, 26.4%) lower cerebral vasoreactivity. Further adjustment for ozone and fine particulate matter (PM2.5) did not materially alter the results. However, we found statistically significant interactions between ambient temperature and PM2.5 such that the association between temperature and blood flow velocity was attenuated at higher levels of PM2.5. CONCLUSIONS:In this elderly population, we found that ambient temperature was negatively associated with cerebral blood flow velocity and cerebrovascular vasoreactivity and positively associated with cerebrovascular resistance. Changes in vascular function may partly underlie the observed associations between ambient temperature and risk of cerebrovascular events.http://europepmc.org/articles/PMC4721538?pdf=render |
| spellingShingle | Wen-Chi Pan Melissa N Eliot Petros Koutrakis Brent A Coull Farzaneh A Sorond Gregory A Wellenius Ambient Temperature and Cerebrovascular Hemodynamics in the Elderly. PLoS ONE |
| title | Ambient Temperature and Cerebrovascular Hemodynamics in the Elderly. |
| title_full | Ambient Temperature and Cerebrovascular Hemodynamics in the Elderly. |
| title_fullStr | Ambient Temperature and Cerebrovascular Hemodynamics in the Elderly. |
| title_full_unstemmed | Ambient Temperature and Cerebrovascular Hemodynamics in the Elderly. |
| title_short | Ambient Temperature and Cerebrovascular Hemodynamics in the Elderly. |
| title_sort | ambient temperature and cerebrovascular hemodynamics in the elderly |
| url | http://europepmc.org/articles/PMC4721538?pdf=render |
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