A PLLA Coating Does Not Affect the Insertion Pressure or Frictional Behavior of a CI Electrode Array at Higher Insertion Speeds
To prevent endocochlear insertion trauma, the development of drug delivery coatings in the field of CI electrodes has become an increasing focus of research. However, so far, the effect of a polymer coating of PLLA on the mechanical properties, such as the insertion pressure and friction of an elect...
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MDPI AG
2022-04-01
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| Online Access: | https://www.mdpi.com/1996-1944/15/9/3049 |
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| author | Dana Dohr Katharina Wulf Niels Grabow Robert Mlynski Sebastian P. Schraven |
| author_facet | Dana Dohr Katharina Wulf Niels Grabow Robert Mlynski Sebastian P. Schraven |
| author_sort | Dana Dohr |
| collection | DOAJ |
| description | To prevent endocochlear insertion trauma, the development of drug delivery coatings in the field of CI electrodes has become an increasing focus of research. However, so far, the effect of a polymer coating of PLLA on the mechanical properties, such as the insertion pressure and friction of an electrode array, has not been investigated. In this study, the insertion pressure of a PLLA-coated, 31.5-mm long standard electrode array was examined during placement in a linear cochlear model. Additionally, the friction coefficients between a PLLA-coated electrode array and a tissue simulating the endocochlear lining were acquired. All data were obtained at different insertion speeds (0.1, 0.5, 1.0, 1.5, and 2.0 mm/s) and compared with those of an uncoated electrode array. It was shown that both the maximum insertion pressure generated in the linear model and the friction coefficient of the PLLA-coated electrode did not depend on the insertion speed. At higher insertion speeds above 1.0 mm/s, the insertion pressure (1.268 ± 0.032 mmHg) and the friction coefficient (0.40 ± 0.15) of the coated electrode array were similar to those of an uncoated array (1.252 ± 0.034 mmHg and 0.36 ± 0.15). The present study reveals that a PLLA coating on cochlear electrode arrays has a negligible effect on the electrode array insertion pressure and the friction when higher insertion speeds are used compared with an uncoated electrode array. Therefore, PLLA is a suitable material to be used as a coating for CI electrode arrays and can be considered for a potential drug delivery system. |
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| id | doaj.art-6ae9cc8d27604f6bb309557c89564d2d |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T03:59:29Z |
| publishDate | 2022-04-01 |
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| series | Materials |
| spelling | doaj.art-6ae9cc8d27604f6bb309557c89564d2d2023-11-23T08:37:18ZengMDPI AGMaterials1996-19442022-04-01159304910.3390/ma15093049A PLLA Coating Does Not Affect the Insertion Pressure or Frictional Behavior of a CI Electrode Array at Higher Insertion SpeedsDana Dohr0Katharina Wulf1Niels Grabow2Robert Mlynski3Sebastian P. Schraven4Department of Otorhinolaryngology, Head and Neck Surgery “Otto Körner”, Rostock University Medical Center, 18057 Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, 18119 Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, 18119 Rostock, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery “Otto Körner”, Rostock University Medical Center, 18057 Rostock, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery “Otto Körner”, Rostock University Medical Center, 18057 Rostock, GermanyTo prevent endocochlear insertion trauma, the development of drug delivery coatings in the field of CI electrodes has become an increasing focus of research. However, so far, the effect of a polymer coating of PLLA on the mechanical properties, such as the insertion pressure and friction of an electrode array, has not been investigated. In this study, the insertion pressure of a PLLA-coated, 31.5-mm long standard electrode array was examined during placement in a linear cochlear model. Additionally, the friction coefficients between a PLLA-coated electrode array and a tissue simulating the endocochlear lining were acquired. All data were obtained at different insertion speeds (0.1, 0.5, 1.0, 1.5, and 2.0 mm/s) and compared with those of an uncoated electrode array. It was shown that both the maximum insertion pressure generated in the linear model and the friction coefficient of the PLLA-coated electrode did not depend on the insertion speed. At higher insertion speeds above 1.0 mm/s, the insertion pressure (1.268 ± 0.032 mmHg) and the friction coefficient (0.40 ± 0.15) of the coated electrode array were similar to those of an uncoated array (1.252 ± 0.034 mmHg and 0.36 ± 0.15). The present study reveals that a PLLA coating on cochlear electrode arrays has a negligible effect on the electrode array insertion pressure and the friction when higher insertion speeds are used compared with an uncoated electrode array. Therefore, PLLA is a suitable material to be used as a coating for CI electrode arrays and can be considered for a potential drug delivery system.https://www.mdpi.com/1996-1944/15/9/3049PLLA coatingcoated cochlear electrode arrayinsertion pressurelinear cochlear modelfriction coefficientinsertion speed |
| spellingShingle | Dana Dohr Katharina Wulf Niels Grabow Robert Mlynski Sebastian P. Schraven A PLLA Coating Does Not Affect the Insertion Pressure or Frictional Behavior of a CI Electrode Array at Higher Insertion Speeds Materials PLLA coating coated cochlear electrode array insertion pressure linear cochlear model friction coefficient insertion speed |
| title | A PLLA Coating Does Not Affect the Insertion Pressure or Frictional Behavior of a CI Electrode Array at Higher Insertion Speeds |
| title_full | A PLLA Coating Does Not Affect the Insertion Pressure or Frictional Behavior of a CI Electrode Array at Higher Insertion Speeds |
| title_fullStr | A PLLA Coating Does Not Affect the Insertion Pressure or Frictional Behavior of a CI Electrode Array at Higher Insertion Speeds |
| title_full_unstemmed | A PLLA Coating Does Not Affect the Insertion Pressure or Frictional Behavior of a CI Electrode Array at Higher Insertion Speeds |
| title_short | A PLLA Coating Does Not Affect the Insertion Pressure or Frictional Behavior of a CI Electrode Array at Higher Insertion Speeds |
| title_sort | plla coating does not affect the insertion pressure or frictional behavior of a ci electrode array at higher insertion speeds |
| topic | PLLA coating coated cochlear electrode array insertion pressure linear cochlear model friction coefficient insertion speed |
| url | https://www.mdpi.com/1996-1944/15/9/3049 |
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