Neutrophils: Innate Effectors of TB Resistance?
Certain individuals are able to resist Mycobacterium tuberculosis infection despite persistent and intense exposure. These persons do not exhibit adaptive immune priming as measured by tuberculin skin test (TST) and interferon-γ (IFN-γ) release assay (IGRA) responses, nor do they develop active tube...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02637/full |
| _version_ | 1819263753975234560 |
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| author | Elouise E. Kroon Anna K. Coussens Anna K. Coussens Anna K. Coussens Craig Kinnear Marianna Orlova Marianna Orlova Marianna Orlova Marlo Möller Allison Seeger Robert J. Wilkinson Robert J. Wilkinson Robert J. Wilkinson Eileen G. Hoal Erwin Schurr Erwin Schurr Erwin Schurr |
| author_facet | Elouise E. Kroon Anna K. Coussens Anna K. Coussens Anna K. Coussens Craig Kinnear Marianna Orlova Marianna Orlova Marianna Orlova Marlo Möller Allison Seeger Robert J. Wilkinson Robert J. Wilkinson Robert J. Wilkinson Eileen G. Hoal Erwin Schurr Erwin Schurr Erwin Schurr |
| author_sort | Elouise E. Kroon |
| collection | DOAJ |
| description | Certain individuals are able to resist Mycobacterium tuberculosis infection despite persistent and intense exposure. These persons do not exhibit adaptive immune priming as measured by tuberculin skin test (TST) and interferon-γ (IFN-γ) release assay (IGRA) responses, nor do they develop active tuberculosis (TB). Genetic investigation of individuals who are able to resist M. tuberculosis infection shows there are likely a combination of genetic variants that contribute to the phenotype. The contribution of the innate immune system and the exact cells involved in this phenotype remain incompletely elucidated. Neutrophils are prominent candidates for possible involvement as primers for microbial clearance. Significant variability is observed in neutrophil gene expression and DNA methylation. Furthermore, inter-individual variability is seen between the mycobactericidal capacities of donor neutrophils. Clearance of M. tuberculosis infection is favored by the mycobactericidal activity of neutrophils, apoptosis, effective clearance of cells by macrophages, and resolution of inflammation. In this review we will discuss the different mechanisms neutrophils utilize to clear M. tuberculosis infection. We discuss the duality between neutrophils' ability to clear infection and how increasing numbers of neutrophils contribute to active TB severity and mortality. Further investigation into the potential role of neutrophils in innate immune-mediated M. tuberculosis infection resistance is warranted since it may reveal clinically important activities for prevention as well as vaccine and treatment development. |
| first_indexed | 2024-12-23T20:18:36Z |
| format | Article |
| id | doaj.art-6aeb8830685444a99e2265ecfc80bdd6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T20:18:36Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6aeb8830685444a99e2265ecfc80bdd62022-12-21T17:32:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-11-01910.3389/fimmu.2018.02637414567Neutrophils: Innate Effectors of TB Resistance?Elouise E. Kroon0Anna K. Coussens1Anna K. Coussens2Anna K. Coussens3Craig Kinnear4Marianna Orlova5Marianna Orlova6Marianna Orlova7Marlo Möller8Allison Seeger9Robert J. Wilkinson10Robert J. Wilkinson11Robert J. Wilkinson12Eileen G. Hoal13Erwin Schurr14Erwin Schurr15Erwin Schurr16DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South AfricaInfection and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, AustraliaDivision of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, AustraliaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaProgram in Infectious Diseases and Immunity in Global Health, The Research Institute of the McGill University Health Centre, Montreal, QC, CanadaMcGill International TB Centre, McGill University, Montreal, QC, CanadaDepartments of Medicine and Human Genetics, McGill University, Montreal, QC, CanadaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South AfricaWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South AfricaDepartment of Medicine, Imperial College London, London, United KingdomThe Francis Crick Institute, London, United KingdomDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaProgram in Infectious Diseases and Immunity in Global Health, The Research Institute of the McGill University Health Centre, Montreal, QC, CanadaMcGill International TB Centre, McGill University, Montreal, QC, CanadaDepartments of Medicine and Human Genetics, McGill University, Montreal, QC, CanadaCertain individuals are able to resist Mycobacterium tuberculosis infection despite persistent and intense exposure. These persons do not exhibit adaptive immune priming as measured by tuberculin skin test (TST) and interferon-γ (IFN-γ) release assay (IGRA) responses, nor do they develop active tuberculosis (TB). Genetic investigation of individuals who are able to resist M. tuberculosis infection shows there are likely a combination of genetic variants that contribute to the phenotype. The contribution of the innate immune system and the exact cells involved in this phenotype remain incompletely elucidated. Neutrophils are prominent candidates for possible involvement as primers for microbial clearance. Significant variability is observed in neutrophil gene expression and DNA methylation. Furthermore, inter-individual variability is seen between the mycobactericidal capacities of donor neutrophils. Clearance of M. tuberculosis infection is favored by the mycobactericidal activity of neutrophils, apoptosis, effective clearance of cells by macrophages, and resolution of inflammation. In this review we will discuss the different mechanisms neutrophils utilize to clear M. tuberculosis infection. We discuss the duality between neutrophils' ability to clear infection and how increasing numbers of neutrophils contribute to active TB severity and mortality. Further investigation into the potential role of neutrophils in innate immune-mediated M. tuberculosis infection resistance is warranted since it may reveal clinically important activities for prevention as well as vaccine and treatment development.https://www.frontiersin.org/article/10.3389/fimmu.2018.02637/fullMycobacteriumtuberculosisinflammationNETsantimicrobialprotection |
| spellingShingle | Elouise E. Kroon Anna K. Coussens Anna K. Coussens Anna K. Coussens Craig Kinnear Marianna Orlova Marianna Orlova Marianna Orlova Marlo Möller Allison Seeger Robert J. Wilkinson Robert J. Wilkinson Robert J. Wilkinson Eileen G. Hoal Erwin Schurr Erwin Schurr Erwin Schurr Neutrophils: Innate Effectors of TB Resistance? Frontiers in Immunology Mycobacterium tuberculosis inflammation NETs antimicrobial protection |
| title | Neutrophils: Innate Effectors of TB Resistance? |
| title_full | Neutrophils: Innate Effectors of TB Resistance? |
| title_fullStr | Neutrophils: Innate Effectors of TB Resistance? |
| title_full_unstemmed | Neutrophils: Innate Effectors of TB Resistance? |
| title_short | Neutrophils: Innate Effectors of TB Resistance? |
| title_sort | neutrophils innate effectors of tb resistance |
| topic | Mycobacterium tuberculosis inflammation NETs antimicrobial protection |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02637/full |
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