Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity mice
Asparagus cochinchinensis is a valuable traditional Chinese medicine that has anti-inflammatory ability and effectively regulates the dysbiosis within the body. Obesity is usually characterized by chronic low-grade inflammation with aberrant gut microbiota. However, the role of Asparagus cochinchine...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1015005/full |
| _version_ | 1798019757723615232 |
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| author | Shiyue Luo Lixiao Zhou Xuejun Jiang Xuejun Jiang Yinyin Xia Yinyin Xia Lishuang Huang Run Ling Shixin Tang Zhen Zou Zhen Zou Chengzhi Chen Chengzhi Chen Jingfu Qiu Jingfu Qiu |
| author_facet | Shiyue Luo Lixiao Zhou Xuejun Jiang Xuejun Jiang Yinyin Xia Yinyin Xia Lishuang Huang Run Ling Shixin Tang Zhen Zou Zhen Zou Chengzhi Chen Chengzhi Chen Jingfu Qiu Jingfu Qiu |
| author_sort | Shiyue Luo |
| collection | DOAJ |
| description | Asparagus cochinchinensis is a valuable traditional Chinese medicine that has anti-inflammatory ability and effectively regulates the dysbiosis within the body. Obesity is usually characterized by chronic low-grade inflammation with aberrant gut microbiota. However, the role of Asparagus cochinchinensis against obesity remains unknown. Therefore, a high-fat diet (HFD)-induced obese mouse model with or without aqueous extract from Asparagus cochinchinensis root (ACE) treatment was established herein to determine whether ACE alleviated obesity and its involved mechanisms. Our results showed that ACE administration significantly decreased the weight gain and relieved dyslipidemia induced by HFD Treatment of ACE also improved glucose tolerance and insulin resistance in obese animal model, and remarkably decreased inflammation and lipogenesis in the liver and adipose. Moreover, administration of ACE significantly reshaped the gut microbiota of obese mice. These findings together suggest that ACE has beneficial effect against HFD-induced obesity and will provide valuable insights for the therapeutic potential of ACE against obesity and may aid in strategy-making for weight loss. |
| first_indexed | 2024-04-11T16:46:06Z |
| format | Article |
| id | doaj.art-6aebf8dec1a14a26b8e93ee70fb3e83e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T16:46:06Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-6aebf8dec1a14a26b8e93ee70fb3e83e2022-12-22T04:13:33ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.10150051015005Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity miceShiyue Luo0Lixiao Zhou1Xuejun Jiang2Xuejun Jiang3Yinyin Xia4Yinyin Xia5Lishuang Huang6Run Ling7Shixin Tang8Zhen Zou9Zhen Zou10Chengzhi Chen11Chengzhi Chen12Jingfu Qiu13Jingfu Qiu14Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing, ChinaCenter of Experimental Teaching for Public Health, Experimental Teaching and Management Center, Chongqing Medical University, Chongqing, ChinaResearch Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, ChinaResearch Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing, ChinaResearch Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, ChinaMolecular Biology Laboratory of Respiratory Diseases, Institute of Life Sciences, Chongqing Medical University, Chongqing, ChinaResearch Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing, ChinaDepartment of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing, ChinaResearch Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, ChinaAsparagus cochinchinensis is a valuable traditional Chinese medicine that has anti-inflammatory ability and effectively regulates the dysbiosis within the body. Obesity is usually characterized by chronic low-grade inflammation with aberrant gut microbiota. However, the role of Asparagus cochinchinensis against obesity remains unknown. Therefore, a high-fat diet (HFD)-induced obese mouse model with or without aqueous extract from Asparagus cochinchinensis root (ACE) treatment was established herein to determine whether ACE alleviated obesity and its involved mechanisms. Our results showed that ACE administration significantly decreased the weight gain and relieved dyslipidemia induced by HFD Treatment of ACE also improved glucose tolerance and insulin resistance in obese animal model, and remarkably decreased inflammation and lipogenesis in the liver and adipose. Moreover, administration of ACE significantly reshaped the gut microbiota of obese mice. These findings together suggest that ACE has beneficial effect against HFD-induced obesity and will provide valuable insights for the therapeutic potential of ACE against obesity and may aid in strategy-making for weight loss.https://www.frontiersin.org/articles/10.3389/fphar.2022.1015005/fullAsparagus cochinchinensisobesityhigh-fat dietlipid metabolismgut microbiota |
| spellingShingle | Shiyue Luo Lixiao Zhou Xuejun Jiang Xuejun Jiang Yinyin Xia Yinyin Xia Lishuang Huang Run Ling Shixin Tang Zhen Zou Zhen Zou Chengzhi Chen Chengzhi Chen Jingfu Qiu Jingfu Qiu Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity mice Frontiers in Pharmacology Asparagus cochinchinensis obesity high-fat diet lipid metabolism gut microbiota |
| title | Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity mice |
| title_full | Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity mice |
| title_fullStr | Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity mice |
| title_full_unstemmed | Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity mice |
| title_short | Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity mice |
| title_sort | asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high fat diet induced obesity mice |
| topic | Asparagus cochinchinensis obesity high-fat diet lipid metabolism gut microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1015005/full |
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