Concordance between Thioacetamide-Induced Liver Injury in Rat and Human In Vitro Gene Expression Data

Concordance between Thioacetamide-Induced Liver Injury in Rat and Human In Vitro Gene Expression Data

The immense resources required and the ethical concerns for animal-based toxicological studies have driven the development of in vitro and in silico approaches. Recently, we validated our approach in which the expression of a set of genes is uniquely associated with an organ-injury phenotype (injury...

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Bibliographic Details
Main Authors: Patric Schyman, Richard L. Printz, Shanea K. Estes, Tracy P. O’Brien, Masakazu Shiota, Anders Wallqvist
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
predictive toxicology
RNA-seq
thioacetamide
toxicogenomics
fibrosis
in vitro–in vivo correlations
Online Access:https://www.mdpi.com/1422-0067/21/11/4017

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