Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms
Saffron, Crocus sativus L. (C. sativus) is rich in carotenoids and used in traditional medicine for treatment of various conditions such as coughs, stomach disorders, amenorrhea, asthma and cardiovascular disorders. These therapeutic effects of the plant are suggested to be due to its relaxant effec...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2015-08-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/pdf_4452_8231f45f9dcfd466807be0cdcaf907e1.html |
| _version_ | 1818287691391827968 |
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| author | Amin Mokhtari-Zaer Mohammad Reza Khazdair Mohammad Hossein Boskabady |
| author_facet | Amin Mokhtari-Zaer Mohammad Reza Khazdair Mohammad Hossein Boskabady |
| author_sort | Amin Mokhtari-Zaer |
| collection | DOAJ |
| description | Saffron, Crocus sativus L. (C. sativus) is rich in carotenoids and used in traditional medicine for treatment of various conditions such as coughs, stomach disorders, amenorrhea, asthma and cardiovascular disorders. These therapeutic effects of the plant are suggested to be due to its relaxant effect on smooth muscles. The effect of C. sativus and its constituents on different smooth muscles and the underlying mechanisms have been studied. Several studies have shown the relaxant effects of C. sativus and its constituents including safranal, crocin, crocetin and kaempferol on blood vessels. In addition, it was reported that saffron stigma lowers systolic blood pressure. The present review highlights the relaxant effects of C. sativus and its constituents on various smooth muscles. The possible mechanisms of this relaxing effect including activation of ß2-adrenoceptors, inhibition of histamine H1 and muscarinic receptors and calcium channels and modulation of nitric oxide (NO) are also reviewed. |
| first_indexed | 2024-12-13T01:44:31Z |
| format | Article |
| id | doaj.art-6aee1dd5ce684afcae8bacaa1b9e254f |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-13T01:44:31Z |
| publishDate | 2015-08-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-6aee1dd5ce684afcae8bacaa1b9e254f2022-12-22T00:03:40ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492015-08-01553653754452Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanismsAmin Mokhtari-Zaer0Mohammad Reza Khazdair1Mohammad Hossein Boskabady2Neurogenic Inflammation Research Centre and Dept. of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranStudent Research Committee, Mashhad University of Medical Sciences, Mashhad, IranNeurogenic Inflammation Research Centre and Dept. of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranSaffron, Crocus sativus L. (C. sativus) is rich in carotenoids and used in traditional medicine for treatment of various conditions such as coughs, stomach disorders, amenorrhea, asthma and cardiovascular disorders. These therapeutic effects of the plant are suggested to be due to its relaxant effect on smooth muscles. The effect of C. sativus and its constituents on different smooth muscles and the underlying mechanisms have been studied. Several studies have shown the relaxant effects of C. sativus and its constituents including safranal, crocin, crocetin and kaempferol on blood vessels. In addition, it was reported that saffron stigma lowers systolic blood pressure. The present review highlights the relaxant effects of C. sativus and its constituents on various smooth muscles. The possible mechanisms of this relaxing effect including activation of ß2-adrenoceptors, inhibition of histamine H1 and muscarinic receptors and calcium channels and modulation of nitric oxide (NO) are also reviewed.http://ajp.mums.ac.ir/pdf_4452_8231f45f9dcfd466807be0cdcaf907e1.htmlCrocus sativusSaffronCrocinSmooth muscleRelaxant effectPossible mechanisms |
| spellingShingle | Amin Mokhtari-Zaer Mohammad Reza Khazdair Mohammad Hossein Boskabady Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms Avicenna Journal of Phytomedicine Crocus sativus Saffron Crocin Smooth muscle Relaxant effect Possible mechanisms |
| title | Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms |
| title_full | Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms |
| title_fullStr | Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms |
| title_full_unstemmed | Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms |
| title_short | Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms |
| title_sort | smooth muscle relaxant activity of crocus sativus saffron and its constituents possible mechanisms |
| topic | Crocus sativus Saffron Crocin Smooth muscle Relaxant effect Possible mechanisms |
| url | http://ajp.mums.ac.ir/pdf_4452_8231f45f9dcfd466807be0cdcaf907e1.html |
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