Exposure to di-2-ethylhexyl phthalate (DEHP) increases the risk of cancer
Abstract Cancer is a major socioeconomic burden that seriously affects the life and spirit of patients. However, little is known about the role of environmental toxicant exposure in diseases, especially ubiquitous di-(2-ethylhexyl) phthalate (DEHP) which is one of the most widely used plasticizers....
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-024-17801-w |
| _version_ | 1797272897941667840 |
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| author | Luchen Yang Xiaoyang Liu Zhufeng Peng Zhenghuan Liu Pan Song Jing Zhou Kai Ma Yunfei Yu Qiang Dong |
| author_facet | Luchen Yang Xiaoyang Liu Zhufeng Peng Zhenghuan Liu Pan Song Jing Zhou Kai Ma Yunfei Yu Qiang Dong |
| author_sort | Luchen Yang |
| collection | DOAJ |
| description | Abstract Cancer is a major socioeconomic burden that seriously affects the life and spirit of patients. However, little is known about the role of environmental toxicant exposure in diseases, especially ubiquitous di-(2-ethylhexyl) phthalate (DEHP) which is one of the most widely used plasticizers. Hence, the objective of this study was to assess the potential association between cancer and DEHP. The data were collected using the 2011–2018 National Health and Nutrition Examination Survey (NHANES) data (n = 6147), and multiple logistic regression was conducted to evaluate the association. The concentrations of DEHP were calculated by each metabolite and split into quartiles for analysis. After adjusting for confounding factors, DEHP was significantly associated with an increased risk of cancer prevalence, and the metabolites of DEHP showed similar results (OR > 1.0, p < 0.05). Simultaneously, the association remained when the analyses were stratified by age and sex, and the risk of cancer appeared to be higher in male patients. In addition, further analysis suggested that DEHP exposure obviously increased the risk of female reproductive system cancer, male reproductive system cancer, and other cancers (OR > 1.0, p < 0.05) but not skin and soft tissue cancer. DEHP exposure is associated with the risk of cancer, especially female reproductive system cancer, male reproductive system cancer and other cancers. |
| first_indexed | 2024-03-07T14:36:51Z |
| format | Article |
| id | doaj.art-6aef1ee8bc0446298a1cfd87fc5f28d3 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-03-07T14:36:51Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-6aef1ee8bc0446298a1cfd87fc5f28d32024-03-05T20:37:30ZengBMCBMC Public Health1471-24582024-02-0124111210.1186/s12889-024-17801-wExposure to di-2-ethylhexyl phthalate (DEHP) increases the risk of cancerLuchen Yang0Xiaoyang Liu1Zhufeng Peng2Zhenghuan Liu3Pan Song4Jing Zhou5Kai Ma6Yunfei Yu7Qiang Dong8Department of Urology, Institute of Urology, West China Hospital of Sichuan UniversityDepartment of Urology, Institute of Urology, West China Hospital of Sichuan UniversityDepartment of Urology, Institute of Urology, West China Hospital of Sichuan UniversityDepartment of Urology, Institute of Urology, West China Hospital of Sichuan UniversityDepartment of Urology, Institute of Urology, West China Hospital of Sichuan UniversityDepartment of Urology, Institute of Urology, West China Hospital of Sichuan UniversityDepartment of Urology, Institute of Urology, West China Hospital of Sichuan UniversityDepartment of Urology, Institute of Urology, West China Hospital of Sichuan UniversityDepartment of Urology, Institute of Urology, West China Hospital of Sichuan UniversityAbstract Cancer is a major socioeconomic burden that seriously affects the life and spirit of patients. However, little is known about the role of environmental toxicant exposure in diseases, especially ubiquitous di-(2-ethylhexyl) phthalate (DEHP) which is one of the most widely used plasticizers. Hence, the objective of this study was to assess the potential association between cancer and DEHP. The data were collected using the 2011–2018 National Health and Nutrition Examination Survey (NHANES) data (n = 6147), and multiple logistic regression was conducted to evaluate the association. The concentrations of DEHP were calculated by each metabolite and split into quartiles for analysis. After adjusting for confounding factors, DEHP was significantly associated with an increased risk of cancer prevalence, and the metabolites of DEHP showed similar results (OR > 1.0, p < 0.05). Simultaneously, the association remained when the analyses were stratified by age and sex, and the risk of cancer appeared to be higher in male patients. In addition, further analysis suggested that DEHP exposure obviously increased the risk of female reproductive system cancer, male reproductive system cancer, and other cancers (OR > 1.0, p < 0.05) but not skin and soft tissue cancer. DEHP exposure is associated with the risk of cancer, especially female reproductive system cancer, male reproductive system cancer and other cancers.https://doi.org/10.1186/s12889-024-17801-wCancerDi-(2-ethylhexyl) phthalate (DEHP)MetabolitesNHANESEpidemiology |
| spellingShingle | Luchen Yang Xiaoyang Liu Zhufeng Peng Zhenghuan Liu Pan Song Jing Zhou Kai Ma Yunfei Yu Qiang Dong Exposure to di-2-ethylhexyl phthalate (DEHP) increases the risk of cancer BMC Public Health Cancer Di-(2-ethylhexyl) phthalate (DEHP) Metabolites NHANES Epidemiology |
| title | Exposure to di-2-ethylhexyl phthalate (DEHP) increases the risk of cancer |
| title_full | Exposure to di-2-ethylhexyl phthalate (DEHP) increases the risk of cancer |
| title_fullStr | Exposure to di-2-ethylhexyl phthalate (DEHP) increases the risk of cancer |
| title_full_unstemmed | Exposure to di-2-ethylhexyl phthalate (DEHP) increases the risk of cancer |
| title_short | Exposure to di-2-ethylhexyl phthalate (DEHP) increases the risk of cancer |
| title_sort | exposure to di 2 ethylhexyl phthalate dehp increases the risk of cancer |
| topic | Cancer Di-(2-ethylhexyl) phthalate (DEHP) Metabolites NHANES Epidemiology |
| url | https://doi.org/10.1186/s12889-024-17801-w |
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