Antidepressant Screening Demonstrated Non-Monotonic Responses to Amitriptyline, Amoxapine and Sertraline in Locomotor Activity Assay in Larval Zebrafish

Antidepressant Screening Demonstrated Non-Monotonic Responses to Amitriptyline, Amoxapine and Sertraline in Locomotor Activity Assay in Larval Zebrafish

Antidepressants are well-known drugs to treat depression and major depressive disorder for humans. However, the misuse and abuse of antidepressants keep increasing with several side effects reported. The aim of this study was to assess the potential adverse effects of 18 antidepressants by monitorin...

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Bibliographic Details
Main Authors: Michael Edbert Suryanto, Gilbert Audira, Boontida Uapipatanakul, Akhlaq Hussain, Ferry Saputra, Petrus Siregar, Kelvin H.-C. Chen, Chung-Der Hsiao
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
zebrafish larvae
antidepressants
behavior
locomotion
phenomics
biphasic effect
Online Access:https://www.mdpi.com/2073-4409/10/4/738

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