Comparison of clinical outcomes following delivery of budesonide by both vibrating mesh nebulizer and jet nebulizer in premature infants with bronchopulmonary dysplasia
BackgroundThis study aimed to compare the efficacy of budesonide inhalation suspension administered via a vibrating mesh nebulizer vs. a jet nebulizer in the treatment of premature infants with bronchopulmonary dysplasia (BPD) undergoing high-frequency oscillatory ventilation (HFOV).MethodsBetween J...
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| Format: | Article |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1258846/full |
| _version_ | 1797465030286901248 |
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| author | Jian-Fu Zhou Jian-Fu Zhou Yi-Bing Zhang Yi-Bing Zhang Zhi-Wei Zhang Zhi-Wei Zhang |
| author_facet | Jian-Fu Zhou Jian-Fu Zhou Yi-Bing Zhang Yi-Bing Zhang Zhi-Wei Zhang Zhi-Wei Zhang |
| author_sort | Jian-Fu Zhou |
| collection | DOAJ |
| description | BackgroundThis study aimed to compare the efficacy of budesonide inhalation suspension administered via a vibrating mesh nebulizer vs. a jet nebulizer in the treatment of premature infants with bronchopulmonary dysplasia (BPD) undergoing high-frequency oscillatory ventilation (HFOV).MethodsBetween July 2020 and July 2022, we retrospectively analyzed the medical records of 36 preterm infants diagnosed with BPD who underwent HFOV. Based on the nebulizer type used, infants were categorized into the vibrating mesh nebulizer group (VMN group) or the jet nebulizer group (JN group). Post-nebulization outcomes, such as the duration of mechanical ventilation, length of stay in the neonatal intensive care unit (NICU), ventilator-associated parameters, and arterial blood gas metrics, were compared between the two groups. Treatment-associated complications were also documented.ResultsNo significant differences were noted between the VMN and JN groups in terms of mechanical ventilation duration (p = 0.519), NICU length of stay (p = 0.112), ventilator-associated parameters, or complications (p = 0.700). However, after 2 weeks of treatment, the oxygenation index (p = 0.012) and arterial partial pressure of carbon dioxide (p = 0.006) were more favorable in the VMN group compared to the JN group.ConclusionAmong premature infants with BPD on HFOV, for administration of budesonide inhalation suspension resulted in an improved oxygenation index and reduced arterial partial pressure of carbon dioxide when compared to a jet nebulizer, indicating superior therapeutic efficacy. |
| first_indexed | 2024-03-09T18:15:43Z |
| format | Article |
| id | doaj.art-6af3822b9f454744b17786207f2a1468 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-09T18:15:43Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-6af3822b9f454744b17786207f2a14682023-11-24T08:43:29ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-11-011110.3389/fped.2023.12588461258846Comparison of clinical outcomes following delivery of budesonide by both vibrating mesh nebulizer and jet nebulizer in premature infants with bronchopulmonary dysplasiaJian-Fu Zhou0Jian-Fu Zhou1Yi-Bing Zhang2Yi-Bing Zhang3Zhi-Wei Zhang4Zhi-Wei Zhang5Fujian Medical University, Fuzhou, ChinaDepartment of Neonatology, The Affiliated Hospital of Putian University, Putian, ChinaFujian Medical University, Fuzhou, ChinaDepartment of Neonatology, The Affiliated Hospital of Putian University, Putian, ChinaFujian Medical University, Fuzhou, ChinaDepartment of Neonatology, The Affiliated Hospital of Putian University, Putian, ChinaBackgroundThis study aimed to compare the efficacy of budesonide inhalation suspension administered via a vibrating mesh nebulizer vs. a jet nebulizer in the treatment of premature infants with bronchopulmonary dysplasia (BPD) undergoing high-frequency oscillatory ventilation (HFOV).MethodsBetween July 2020 and July 2022, we retrospectively analyzed the medical records of 36 preterm infants diagnosed with BPD who underwent HFOV. Based on the nebulizer type used, infants were categorized into the vibrating mesh nebulizer group (VMN group) or the jet nebulizer group (JN group). Post-nebulization outcomes, such as the duration of mechanical ventilation, length of stay in the neonatal intensive care unit (NICU), ventilator-associated parameters, and arterial blood gas metrics, were compared between the two groups. Treatment-associated complications were also documented.ResultsNo significant differences were noted between the VMN and JN groups in terms of mechanical ventilation duration (p = 0.519), NICU length of stay (p = 0.112), ventilator-associated parameters, or complications (p = 0.700). However, after 2 weeks of treatment, the oxygenation index (p = 0.012) and arterial partial pressure of carbon dioxide (p = 0.006) were more favorable in the VMN group compared to the JN group.ConclusionAmong premature infants with BPD on HFOV, for administration of budesonide inhalation suspension resulted in an improved oxygenation index and reduced arterial partial pressure of carbon dioxide when compared to a jet nebulizer, indicating superior therapeutic efficacy.https://www.frontiersin.org/articles/10.3389/fped.2023.1258846/fullinfantbronchopulmonary dysplasiavibrating mesh nebulizerjet nebulizerhigh-frequency oscillatory ventilation |
| spellingShingle | Jian-Fu Zhou Jian-Fu Zhou Yi-Bing Zhang Yi-Bing Zhang Zhi-Wei Zhang Zhi-Wei Zhang Comparison of clinical outcomes following delivery of budesonide by both vibrating mesh nebulizer and jet nebulizer in premature infants with bronchopulmonary dysplasia Frontiers in Pediatrics infant bronchopulmonary dysplasia vibrating mesh nebulizer jet nebulizer high-frequency oscillatory ventilation |
| title | Comparison of clinical outcomes following delivery of budesonide by both vibrating mesh nebulizer and jet nebulizer in premature infants with bronchopulmonary dysplasia |
| title_full | Comparison of clinical outcomes following delivery of budesonide by both vibrating mesh nebulizer and jet nebulizer in premature infants with bronchopulmonary dysplasia |
| title_fullStr | Comparison of clinical outcomes following delivery of budesonide by both vibrating mesh nebulizer and jet nebulizer in premature infants with bronchopulmonary dysplasia |
| title_full_unstemmed | Comparison of clinical outcomes following delivery of budesonide by both vibrating mesh nebulizer and jet nebulizer in premature infants with bronchopulmonary dysplasia |
| title_short | Comparison of clinical outcomes following delivery of budesonide by both vibrating mesh nebulizer and jet nebulizer in premature infants with bronchopulmonary dysplasia |
| title_sort | comparison of clinical outcomes following delivery of budesonide by both vibrating mesh nebulizer and jet nebulizer in premature infants with bronchopulmonary dysplasia |
| topic | infant bronchopulmonary dysplasia vibrating mesh nebulizer jet nebulizer high-frequency oscillatory ventilation |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1258846/full |
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