Dynamics of clinical, functional, and immune parameters in patients with myocardial infarction and early fluvastatin administration
Aim. To assess the interrelations in the dynamics of immune, clinical, and functional parameters among patients with myocardial infarction (MI) and early fluvastatin administration. Material and methods. The study included 129 men, aged from 42 to 67 years (mean age 57 years): 99 MI patients and 30...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2011-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1896 |
| _version_ | 1797882596524294144 |
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| author | V. V. Belov S. Yu. Bezdol’nova I. I. Dolgushin |
| author_facet | V. V. Belov S. Yu. Bezdol’nova I. I. Dolgushin |
| author_sort | V. V. Belov |
| collection | DOAJ |
| description | Aim. To assess the interrelations in the dynamics of immune, clinical, and functional parameters among patients with myocardial infarction (MI) and early fluvastatin administration. Material and methods. The study included 129 men, aged from 42 to 67 years (mean age 57 years): 99 MI patients and 30 healthy controls. In all participants, clinical, biochemical, functional, and immune parameters were assessed, with comparisons between healthy individuals vs. MI patients, as well as between MI patients taking fluvastatin (80 mg/d) vs. MI patients not receiving this medication. Results. In men with MI, chronic systemic inflammation was manifested in elevated levels of C-reactive protein, interleukin (IL) 1β, IL8, tumor necrosis factor α, immunoglobulin A and G, and complement components, as well as in decreased levels of IL1 receptor antagonist, CD 3, CD 4, CD 16, and CD 4/CD 8, compared to healthy controls. Early fluvastatin administration (first post-MI hours) was associated with reduced severity of immune disturbances and systemic inflammation. Conclusion. In MI patients, early fluvastatin administration is associated with a significant reduction in systolic and diastolic blood pressure levels, compared to controls, as well as with a substantial increase in exercise capacity at 2 months. |
| first_indexed | 2024-04-10T03:38:21Z |
| format | Article |
| id | doaj.art-6af421b1fd7842c09d25bb0f728b08d9 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:38:21Z |
| publishDate | 2011-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-6af421b1fd7842c09d25bb0f728b08d92023-03-13T07:23:19Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252011-08-01104525810.15829/1728-8800-2011-4-52-581611Dynamics of clinical, functional, and immune parameters in patients with myocardial infarction and early fluvastatin administrationV. V. Belov0S. Yu. Bezdol’nova1I. I. Dolgushin2ГОУ ВПО “Челябинская государственная медицинская академия Росздрава”ГОУ ВПО “Челябинская государственная медицинская академия Росздрава”ГОУ ВПО “Челябинская государственная медицинская академия Росздрава”Aim. To assess the interrelations in the dynamics of immune, clinical, and functional parameters among patients with myocardial infarction (MI) and early fluvastatin administration. Material and methods. The study included 129 men, aged from 42 to 67 years (mean age 57 years): 99 MI patients and 30 healthy controls. In all participants, clinical, biochemical, functional, and immune parameters were assessed, with comparisons between healthy individuals vs. MI patients, as well as between MI patients taking fluvastatin (80 mg/d) vs. MI patients not receiving this medication. Results. In men with MI, chronic systemic inflammation was manifested in elevated levels of C-reactive protein, interleukin (IL) 1β, IL8, tumor necrosis factor α, immunoglobulin A and G, and complement components, as well as in decreased levels of IL1 receptor antagonist, CD 3, CD 4, CD 16, and CD 4/CD 8, compared to healthy controls. Early fluvastatin administration (first post-MI hours) was associated with reduced severity of immune disturbances and systemic inflammation. Conclusion. In MI patients, early fluvastatin administration is associated with a significant reduction in systolic and diastolic blood pressure levels, compared to controls, as well as with a substantial increase in exercise capacity at 2 months.https://cardiovascular.elpub.ru/jour/article/view/1896инфаркт миокардавоспалениефлувастатинфункциональные показатели |
| spellingShingle | V. V. Belov S. Yu. Bezdol’nova I. I. Dolgushin Dynamics of clinical, functional, and immune parameters in patients with myocardial infarction and early fluvastatin administration Кардиоваскулярная терапия и профилактика инфаркт миокарда воспаление флувастатин функциональные показатели |
| title | Dynamics of clinical, functional, and immune parameters in patients with myocardial infarction and early fluvastatin administration |
| title_full | Dynamics of clinical, functional, and immune parameters in patients with myocardial infarction and early fluvastatin administration |
| title_fullStr | Dynamics of clinical, functional, and immune parameters in patients with myocardial infarction and early fluvastatin administration |
| title_full_unstemmed | Dynamics of clinical, functional, and immune parameters in patients with myocardial infarction and early fluvastatin administration |
| title_short | Dynamics of clinical, functional, and immune parameters in patients with myocardial infarction and early fluvastatin administration |
| title_sort | dynamics of clinical functional and immune parameters in patients with myocardial infarction and early fluvastatin administration |
| topic | инфаркт миокарда воспаление флувастатин функциональные показатели |
| url | https://cardiovascular.elpub.ru/jour/article/view/1896 |
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