DiDang Tang Inhibits Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Oxygen Glucose Deprivation and Intracerebral Hemorrhage Through Blockade of the GRP78-IRE1/PERK Pathways

DiDang Tang Inhibits Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Oxygen Glucose Deprivation and Intracerebral Hemorrhage Through Blockade of the GRP78-IRE1/PERK Pathways

DiDang Tang (DDT), a Chinese traditional medicine formula, contains 4 Chinese traditional medicine substances, has been widely used to treat intracerebral hemorrhage (ICH) patients. However, the molecular mechanisms of DDT for protecting neurons from oxygen and glucose deprivation (OGD)-induced endo...

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Bibliographic Details
Main Authors: Qingxia Huang, Tianye Lan, Jing Lu, He Zhang, Dongmei Zhang, Tingting Lou, Peng Xu, Jixiang Ren, Daqing Zhao, Liwei Sun, Xiangyan Li, Jian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Pharmacology
Subjects:
oxygen and glucose deprivation
endoplasmic reticulum stress (ER stress)
DiDang Tang
mitochondrial dysfunction
apoptosis
GRP78-IRE1/PERK pathways
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01423/full

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