中国成年2型糖尿病患者的肾脏疾病参数、代谢目标实现情况和动脉硬化风险
Abstract Background To investigate the arterial stiffness (AS) risk within urinary albumin‐to‐creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) categories and the joint effect between kidney disease parameters and metabolic goal achievement on AS risk in adult people with type...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-05-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13269 |
| _version_ | 1811177937221713920 |
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| author | Chen Xu Li Li Juan Shi Bangqun Ji Qidong Zheng Yufan Wang Tingyu Ke Li Li Dong Zhao Yuancheng Dai Fengmei Xu Ying Peng Yifei Zhang Qijuan Dong Weiqing Wang |
| author_facet | Chen Xu Li Li Juan Shi Bangqun Ji Qidong Zheng Yufan Wang Tingyu Ke Li Li Dong Zhao Yuancheng Dai Fengmei Xu Ying Peng Yifei Zhang Qijuan Dong Weiqing Wang |
| author_sort | Chen Xu |
| collection | DOAJ |
| description | Abstract Background To investigate the arterial stiffness (AS) risk within urinary albumin‐to‐creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) categories and the joint effect between kidney disease parameters and metabolic goal achievement on AS risk in adult people with type 2 diabetes (T2D). Methods A total of 27 439 Chinese participants with T2D from 10 National Metabolic Management Centers (MMC) were categorized into four albuminuria/decreased eGFR groups. The criteria for decreased eGFR and AS were eGFR <90 ml/min/1.73 m2 and brachial‐ankle pulse wave velocity value >the 75th percentile (1770.0 cm/s). Three metabolic goals were defined as glycated hemoglobin <7%, BP <130/80 mmHg, andlow‐density lipoprotein cholesterol <2.6 mmol/L. Results After full adjustment, odds ratios (ORs) for AS were highest for albuminuria and decreased eGFR (2.23 [1.98–2.52]) and were higher for albuminuria and normal eGFR (1.52 [1.39–1.67]) than for those with nonalbuminuria and decreased eGFR (1.17 [1.04–1.32]). Both UACR and eGFR in the subgroup or overall population independently correlated with AS risk. The achievement of ≥2 metabolic goals counteracted the association between albuminuria and AS risk (OR: 0.93; 95% CI: 0.80–1.07; p = .311). When the metabolic goals added up to ≥2 for patients with decreased eGFR, they showed significantly lower AS risk (OR: 0.65; 95% CI: 0.56–0.74; p < .001). Conclusions Both higher UACR and lower eGFR are determinants of AS risk, with UACR more strongly related to AS than eGFR in adults with T2D. The correlation between albuminuria/decreased eGFR and AS was modified by the achievement of multiple metabolic elements. |
| first_indexed | 2024-04-11T06:09:42Z |
| format | Article |
| id | doaj.art-6af72395c00f4130b869560348e130aa |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-04-11T06:09:42Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-6af72395c00f4130b869560348e130aa2022-12-22T04:41:18ZengWileyJournal of Diabetes1753-03931753-04072022-05-0114534535510.1111/1753-0407.13269中国成年2型糖尿病患者的肾脏疾病参数、代谢目标实现情况和动脉硬化风险Chen Xu0Li Li1Juan Shi2Bangqun Ji3Qidong Zheng4Yufan Wang5Tingyu Ke6Li Li7Dong Zhao8Yuancheng Dai9Fengmei Xu10Ying Peng11Yifei Zhang12Qijuan Dong13Weiqing Wang14Department of Endocrinology and Metabolism People′s Hospital of Zhengzhou Affiliated Henan University of Chinese Medicine Zhengzhou ChinaDepartment of Endocrinology and Metabolism People′s Hospital of Zhengzhou Affiliated Henan University of Chinese Medicine Zhengzhou ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Endocrinology Xingyi People′s Hospital Xingyi ChinaDepartment of Internal medicine The Second People′s Hospital of Yuhuan Yuhuan ChinaDepartment of Endocrinology and Metabolism Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Endocrinology The Second Affiliated Hospital of Kunming Medical University Kunming ChinaDepartment of Endocrinology Ningbo First Hospital Ningbo ChinaCenter for Endocrine Metabolism and Immune Diseases Beijing Luhe Hospital, Capital Medical University Beijing ChinaDepartment of Internal medicine of traditional Chinese medicine Sheyang Diabetes Hospital Yancheng ChinaDepartment of Endocrinology and Metabolism Hebi Coal (Group), LTD, General Hospital Hebi ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Endocrinology and Metabolism People′s Hospital of Zhengzhou Affiliated Henan University of Chinese Medicine Zhengzhou ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai ChinaAbstract Background To investigate the arterial stiffness (AS) risk within urinary albumin‐to‐creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) categories and the joint effect between kidney disease parameters and metabolic goal achievement on AS risk in adult people with type 2 diabetes (T2D). Methods A total of 27 439 Chinese participants with T2D from 10 National Metabolic Management Centers (MMC) were categorized into four albuminuria/decreased eGFR groups. The criteria for decreased eGFR and AS were eGFR <90 ml/min/1.73 m2 and brachial‐ankle pulse wave velocity value >the 75th percentile (1770.0 cm/s). Three metabolic goals were defined as glycated hemoglobin <7%, BP <130/80 mmHg, andlow‐density lipoprotein cholesterol <2.6 mmol/L. Results After full adjustment, odds ratios (ORs) for AS were highest for albuminuria and decreased eGFR (2.23 [1.98–2.52]) and were higher for albuminuria and normal eGFR (1.52 [1.39–1.67]) than for those with nonalbuminuria and decreased eGFR (1.17 [1.04–1.32]). Both UACR and eGFR in the subgroup or overall population independently correlated with AS risk. The achievement of ≥2 metabolic goals counteracted the association between albuminuria and AS risk (OR: 0.93; 95% CI: 0.80–1.07; p = .311). When the metabolic goals added up to ≥2 for patients with decreased eGFR, they showed significantly lower AS risk (OR: 0.65; 95% CI: 0.56–0.74; p < .001). Conclusions Both higher UACR and lower eGFR are determinants of AS risk, with UACR more strongly related to AS than eGFR in adults with T2D. The correlation between albuminuria/decreased eGFR and AS was modified by the achievement of multiple metabolic elements.https://doi.org/10.1111/1753-0407.132692型糖尿病尿白蛋白/肌酐比值(UACR)估计肾小球滤过率(eGFR)臂‐踝脉搏波传导速度(BaPWV)心血管疾病代谢目标 |
| spellingShingle | Chen Xu Li Li Juan Shi Bangqun Ji Qidong Zheng Yufan Wang Tingyu Ke Li Li Dong Zhao Yuancheng Dai Fengmei Xu Ying Peng Yifei Zhang Qijuan Dong Weiqing Wang 中国成年2型糖尿病患者的肾脏疾病参数、代谢目标实现情况和动脉硬化风险 Journal of Diabetes 2型糖尿病 尿白蛋白/肌酐比值(UACR) 估计肾小球滤过率(eGFR) 臂‐踝脉搏波传导速度(BaPWV) 心血管疾病 代谢目标 |
| title | 中国成年2型糖尿病患者的肾脏疾病参数、代谢目标实现情况和动脉硬化风险 |
| title_full | 中国成年2型糖尿病患者的肾脏疾病参数、代谢目标实现情况和动脉硬化风险 |
| title_fullStr | 中国成年2型糖尿病患者的肾脏疾病参数、代谢目标实现情况和动脉硬化风险 |
| title_full_unstemmed | 中国成年2型糖尿病患者的肾脏疾病参数、代谢目标实现情况和动脉硬化风险 |
| title_short | 中国成年2型糖尿病患者的肾脏疾病参数、代谢目标实现情况和动脉硬化风险 |
| title_sort | 中国成年2型糖尿病患者的肾脏疾病参数 代谢目标实现情况和动脉硬化风险 |
| topic | 2型糖尿病 尿白蛋白/肌酐比值(UACR) 估计肾小球滤过率(eGFR) 臂‐踝脉搏波传导速度(BaPWV) 心血管疾病 代谢目标 |
| url | https://doi.org/10.1111/1753-0407.13269 |
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