Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative dataResearch in context
Summary: Background: Post-acute sequelae after SARS-CoV-2 infection (PASC) remains a concerning long-term complication of COVID-19. Here, we aimed to characterize the epidemiology of PASC in Mexico during 2022 and identify potential associations of covariates with PASC prevalence using nationally r...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | The Lancet Regional Health. Americas |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667193X24000152 |
| _version_ | 1797326225504468992 |
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| author | Omar Yaxmehen Bello-Chavolla Carlos A. Fermín-Martínez Daniel Ramírez-García Arsenio Vargas-Vázquez Luisa Fernández-Chirino Martín Roberto Basile-Alvarez Paulina Sánchez-Castro Alejandra Núñez-Luna Neftali Eduardo Antonio-Villa |
| author_facet | Omar Yaxmehen Bello-Chavolla Carlos A. Fermín-Martínez Daniel Ramírez-García Arsenio Vargas-Vázquez Luisa Fernández-Chirino Martín Roberto Basile-Alvarez Paulina Sánchez-Castro Alejandra Núñez-Luna Neftali Eduardo Antonio-Villa |
| author_sort | Omar Yaxmehen Bello-Chavolla |
| collection | DOAJ |
| description | Summary: Background: Post-acute sequelae after SARS-CoV-2 infection (PASC) remains a concerning long-term complication of COVID-19. Here, we aimed to characterize the epidemiology of PASC in Mexico during 2022 and identify potential associations of covariates with PASC prevalence using nationally representative data. Methods: We analyzed data from the 2022 Mexican National Health and Nutrition Survey (ENSANUT) from 24,434 participants, representing 85,521,661 adults ≥20 years. PASC was defined using both the National Institute for Health and Care Excellence (NICE) definition and a PASC score ≥12. Estimates of PASC prevalence were stratified by age, sex, rural vs. urban setting, social lag quartiles, number of reinfections, vaccination status and periods of predominance of SARS-CoV-2 circulating variants. Determinants of PASC were assessed using log-binomial regression models adjusted by survey weights. Findings: Persistent symptoms after SARS-CoV-2 infection were reported by 12.44% (95% CI 11.89–12.99) of adults ≥20 years in Mexico in 2022. The most common persistent symptoms were fatigue, musculoskeletal pain, headache, cough, loss of smell or taste, fever, post-exertional malaise, brain fog, anxiety, and chest pain. PASC was present in 21.21% (95% CI 19.74–22.68) of subjects with previously diagnosed COVID-19. Over 28.6% of patients with PASC reported symptoms persistence ≥6 months and 14.05% reported incapacitating symptoms. Higher PASC prevalence was associated with SARS-CoV-2 reinfections, depressive symptoms and living in states with high social lag. PASC prevalence, particularly its more severe forms, decreased with COVID-19 vaccination and for infections during periods of Omicron variant predominance. Interpretation: PASC remains a significant public health burden in Mexico as the COVID-19 pandemic transitions into endemic. Promoting SARS-CoV-2 reinfection prevention and booster vaccination may be useful in reducing PASC burden. Funding: This research was supported by Instituto Nacional de Geriatría in Mexico. |
| first_indexed | 2024-03-08T06:20:22Z |
| format | Article |
| id | doaj.art-6af794baf5854b1caaba7faff7dd9600 |
| institution | Directory Open Access Journal |
| issn | 2667-193X |
| language | English |
| last_indexed | 2024-03-08T06:20:22Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Americas |
| spelling | doaj.art-6af794baf5854b1caaba7faff7dd96002024-02-04T04:47:03ZengElsevierThe Lancet Regional Health. Americas2667-193X2024-02-0130100688Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative dataResearch in contextOmar Yaxmehen Bello-Chavolla0Carlos A. Fermín-Martínez1Daniel Ramírez-García2Arsenio Vargas-Vázquez3Luisa Fernández-Chirino4Martín Roberto Basile-Alvarez5Paulina Sánchez-Castro6Alejandra Núñez-Luna7Neftali Eduardo Antonio-Villa8Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico; Corresponding author. Division of Research, Instituto Nacional de Geriatría, Anillo Perif. 2767, San Jerónimo Lídice, La Magdalena Contreras, 10200, Mexico City, Mexico.Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico; MD/PhD (PECEM) Program, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoResearch Division, Instituto Nacional de Geriatría, Mexico City, Mexico; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoFacultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoResearch Division, Instituto Nacional de Geriatría, Mexico City, MexicoResearch Division, Instituto Nacional de Geriatría, Mexico City, Mexico; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoResearch Division, Instituto Nacional de Geriatría, Mexico City, Mexico; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoResearch Division, Instituto Nacional de Geriatría, Mexico City, Mexico; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoSummary: Background: Post-acute sequelae after SARS-CoV-2 infection (PASC) remains a concerning long-term complication of COVID-19. Here, we aimed to characterize the epidemiology of PASC in Mexico during 2022 and identify potential associations of covariates with PASC prevalence using nationally representative data. Methods: We analyzed data from the 2022 Mexican National Health and Nutrition Survey (ENSANUT) from 24,434 participants, representing 85,521,661 adults ≥20 years. PASC was defined using both the National Institute for Health and Care Excellence (NICE) definition and a PASC score ≥12. Estimates of PASC prevalence were stratified by age, sex, rural vs. urban setting, social lag quartiles, number of reinfections, vaccination status and periods of predominance of SARS-CoV-2 circulating variants. Determinants of PASC were assessed using log-binomial regression models adjusted by survey weights. Findings: Persistent symptoms after SARS-CoV-2 infection were reported by 12.44% (95% CI 11.89–12.99) of adults ≥20 years in Mexico in 2022. The most common persistent symptoms were fatigue, musculoskeletal pain, headache, cough, loss of smell or taste, fever, post-exertional malaise, brain fog, anxiety, and chest pain. PASC was present in 21.21% (95% CI 19.74–22.68) of subjects with previously diagnosed COVID-19. Over 28.6% of patients with PASC reported symptoms persistence ≥6 months and 14.05% reported incapacitating symptoms. Higher PASC prevalence was associated with SARS-CoV-2 reinfections, depressive symptoms and living in states with high social lag. PASC prevalence, particularly its more severe forms, decreased with COVID-19 vaccination and for infections during periods of Omicron variant predominance. Interpretation: PASC remains a significant public health burden in Mexico as the COVID-19 pandemic transitions into endemic. Promoting SARS-CoV-2 reinfection prevention and booster vaccination may be useful in reducing PASC burden. Funding: This research was supported by Instituto Nacional de Geriatría in Mexico.http://www.sciencedirect.com/science/article/pii/S2667193X24000152Long COVIDPASCMexicoCOVID-19Sequelae |
| spellingShingle | Omar Yaxmehen Bello-Chavolla Carlos A. Fermín-Martínez Daniel Ramírez-García Arsenio Vargas-Vázquez Luisa Fernández-Chirino Martín Roberto Basile-Alvarez Paulina Sánchez-Castro Alejandra Núñez-Luna Neftali Eduardo Antonio-Villa Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative dataResearch in context The Lancet Regional Health. Americas Long COVID PASC Mexico COVID-19 Sequelae |
| title | Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative dataResearch in context |
| title_full | Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative dataResearch in context |
| title_fullStr | Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative dataResearch in context |
| title_full_unstemmed | Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative dataResearch in context |
| title_short | Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative dataResearch in context |
| title_sort | prevalence and determinants of post acute sequelae after sars cov 2 infection long covid among adults in mexico during 2022 a retrospective analysis of nationally representative dataresearch in context |
| topic | Long COVID PASC Mexico COVID-19 Sequelae |
| url | http://www.sciencedirect.com/science/article/pii/S2667193X24000152 |
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