Association between the ABO blood group and the human intestinal microbiota composition
<p>Abstract</p> <p>Background</p> <p>The mucus layer covering the human intestinal epithelium forms a dynamic surface for host-microbial interactions. In addition to the environmental factors affecting the intestinal equilibrium, such as diet, it is well established tha...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-06-01
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| Series: | BMC Microbiology |
| Online Access: | http://www.biomedcentral.com/1471-2180/12/94 |
| _version_ | 1818208185460195328 |
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| author | Mäkivuokko Harri Lahtinen Sampo J Wacklin Pirjo Tuovinen Elina Tenkanen Heli Nikkilä Janne Björklund Marika Aranko Kari Ouwehand Arthur C Mättö Jaana |
| author_facet | Mäkivuokko Harri Lahtinen Sampo J Wacklin Pirjo Tuovinen Elina Tenkanen Heli Nikkilä Janne Björklund Marika Aranko Kari Ouwehand Arthur C Mättö Jaana |
| author_sort | Mäkivuokko Harri |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The mucus layer covering the human intestinal epithelium forms a dynamic surface for host-microbial interactions. In addition to the environmental factors affecting the intestinal equilibrium, such as diet, it is well established that the microbiota composition is individually driven, but the host factors determining the composition have remained unresolved.</p> <p>Results</p> <p>In this study, we show that ABO blood group is involved in differences in relative proportion and overall profiles of intestinal microbiota. Specifically, the microbiota from the individuals harbouring the B antigen (secretor B and AB) differed from the non-B antigen groups and also showed higher diversity of the Eubacterium rectale-Clostridium coccoides (EREC) and Clostridium leptum (CLEPT) -groups in comparison with other blood groups.</p> <p>Conclusions</p> <p>Our novel finding indicates that the ABO blood group is one of the genetically determined host factors modulating the composition of the human intestinal microbiota, thus enabling new applications in the field of personalized nutrition and medicine.</p> |
| first_indexed | 2024-12-12T04:40:48Z |
| format | Article |
| id | doaj.art-6af929245d604b63aae669e9d589f090 |
| institution | Directory Open Access Journal |
| issn | 1471-2180 |
| language | English |
| last_indexed | 2024-12-12T04:40:48Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj.art-6af929245d604b63aae669e9d589f0902022-12-22T00:37:50ZengBMCBMC Microbiology1471-21802012-06-011219410.1186/1471-2180-12-94Association between the ABO blood group and the human intestinal microbiota compositionMäkivuokko HarriLahtinen Sampo JWacklin PirjoTuovinen ElinaTenkanen HeliNikkilä JanneBjörklund MarikaAranko KariOuwehand Arthur CMättö Jaana<p>Abstract</p> <p>Background</p> <p>The mucus layer covering the human intestinal epithelium forms a dynamic surface for host-microbial interactions. In addition to the environmental factors affecting the intestinal equilibrium, such as diet, it is well established that the microbiota composition is individually driven, but the host factors determining the composition have remained unresolved.</p> <p>Results</p> <p>In this study, we show that ABO blood group is involved in differences in relative proportion and overall profiles of intestinal microbiota. Specifically, the microbiota from the individuals harbouring the B antigen (secretor B and AB) differed from the non-B antigen groups and also showed higher diversity of the Eubacterium rectale-Clostridium coccoides (EREC) and Clostridium leptum (CLEPT) -groups in comparison with other blood groups.</p> <p>Conclusions</p> <p>Our novel finding indicates that the ABO blood group is one of the genetically determined host factors modulating the composition of the human intestinal microbiota, thus enabling new applications in the field of personalized nutrition and medicine.</p>http://www.biomedcentral.com/1471-2180/12/94 |
| spellingShingle | Mäkivuokko Harri Lahtinen Sampo J Wacklin Pirjo Tuovinen Elina Tenkanen Heli Nikkilä Janne Björklund Marika Aranko Kari Ouwehand Arthur C Mättö Jaana Association between the ABO blood group and the human intestinal microbiota composition BMC Microbiology |
| title | Association between the ABO blood group and the human intestinal microbiota composition |
| title_full | Association between the ABO blood group and the human intestinal microbiota composition |
| title_fullStr | Association between the ABO blood group and the human intestinal microbiota composition |
| title_full_unstemmed | Association between the ABO blood group and the human intestinal microbiota composition |
| title_short | Association between the ABO blood group and the human intestinal microbiota composition |
| title_sort | association between the abo blood group and the human intestinal microbiota composition |
| url | http://www.biomedcentral.com/1471-2180/12/94 |
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