Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain
Epilepsy is a chronic, neurological disorder affecting millions of people every year. The current available pharmacological and surgical treatments are lacking in overall efficacy and cause side-effects like cognitive impairment, depression, tremor, abnormal liver and kidney function. In recent year...
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2020-12-01
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author | Bram Vandekerckhove Jeroen Missinne Kristl Vonck Pieter Bauwens Rik Verplancke Paul Boon Robrecht Raedt Jan Vanfleteren |
author_facet | Bram Vandekerckhove Jeroen Missinne Kristl Vonck Pieter Bauwens Rik Verplancke Paul Boon Robrecht Raedt Jan Vanfleteren |
author_sort | Bram Vandekerckhove |
collection | DOAJ |
description | Epilepsy is a chronic, neurological disorder affecting millions of people every year. The current available pharmacological and surgical treatments are lacking in overall efficacy and cause side-effects like cognitive impairment, depression, tremor, abnormal liver and kidney function. In recent years, the application of optogenetic implants have shown promise to target aberrant neuronal circuits in epilepsy with the advantage of both high spatial and temporal resolution and high cell-specificity, a feature that could tackle both the efficacy and side-effect problems in epilepsy treatment. Optrodes consist of electrodes to record local field potentials and an optical component to modulate neurons via activation of opsin expressed by these neurons. The goal of optogenetics in epilepsy is to interrupt seizure activity in its earliest state, providing a so-called closed-loop therapeutic intervention. The chronic implantation in vivo poses specific demands for the engineering of therapeutic optrodes. Enzymatic degradation and glial encapsulation of implants may compromise long-term recording and sufficient illumination of the opsin-expressing neural tissue. Engineering efforts for optimal optrode design have to be directed towards limitation of the foreign body reaction by reducing the implant’s elastic modulus and overall size, while still providing stable long-term recording and large-area illumination, and guaranteeing successful intracerebral implantation. This paper presents an overview of the challenges and recent advances in the field of electrode design, neural-tissue illumination, and neural-probe implantation, with the goal of identifying a suitable candidate to be incorporated in a therapeutic approach for long-term treatment of epilepsy patients. |
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issn | 2072-666X |
language | English |
last_indexed | 2024-03-10T13:36:48Z |
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spelling | doaj.art-6afa4436f618491d9bcaa8748df59a6e2023-11-21T07:28:41ZengMDPI AGMicromachines2072-666X2020-12-011213810.3390/mi12010038Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the BrainBram Vandekerckhove0Jeroen Missinne1Kristl Vonck2Pieter Bauwens3Rik Verplancke4Paul Boon5Robrecht Raedt6Jan Vanfleteren7Center for Microsystems Technology, Imec and Ghent University, 9000 Ghent, BelgiumCenter for Microsystems Technology, Imec and Ghent University, 9000 Ghent, Belgium4Brain Team, Department of Head and Skin, Ghent University, 9000 Ghent, BelgiumCenter for Microsystems Technology, Imec and Ghent University, 9000 Ghent, BelgiumCenter for Microsystems Technology, Imec and Ghent University, 9000 Ghent, Belgium4Brain Team, Department of Head and Skin, Ghent University, 9000 Ghent, Belgium4Brain Team, Department of Head and Skin, Ghent University, 9000 Ghent, BelgiumCenter for Microsystems Technology, Imec and Ghent University, 9000 Ghent, BelgiumEpilepsy is a chronic, neurological disorder affecting millions of people every year. The current available pharmacological and surgical treatments are lacking in overall efficacy and cause side-effects like cognitive impairment, depression, tremor, abnormal liver and kidney function. In recent years, the application of optogenetic implants have shown promise to target aberrant neuronal circuits in epilepsy with the advantage of both high spatial and temporal resolution and high cell-specificity, a feature that could tackle both the efficacy and side-effect problems in epilepsy treatment. Optrodes consist of electrodes to record local field potentials and an optical component to modulate neurons via activation of opsin expressed by these neurons. The goal of optogenetics in epilepsy is to interrupt seizure activity in its earliest state, providing a so-called closed-loop therapeutic intervention. The chronic implantation in vivo poses specific demands for the engineering of therapeutic optrodes. Enzymatic degradation and glial encapsulation of implants may compromise long-term recording and sufficient illumination of the opsin-expressing neural tissue. Engineering efforts for optimal optrode design have to be directed towards limitation of the foreign body reaction by reducing the implant’s elastic modulus and overall size, while still providing stable long-term recording and large-area illumination, and guaranteeing successful intracerebral implantation. This paper presents an overview of the challenges and recent advances in the field of electrode design, neural-tissue illumination, and neural-probe implantation, with the goal of identifying a suitable candidate to be incorporated in a therapeutic approach for long-term treatment of epilepsy patients.https://www.mdpi.com/2072-666X/12/1/38optogeneticsoptrodebrainepilepsybiocompatibilityclosed-loop therapy |
spellingShingle | Bram Vandekerckhove Jeroen Missinne Kristl Vonck Pieter Bauwens Rik Verplancke Paul Boon Robrecht Raedt Jan Vanfleteren Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain Micromachines optogenetics optrode brain epilepsy biocompatibility closed-loop therapy |
title | Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain |
title_full | Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain |
title_fullStr | Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain |
title_full_unstemmed | Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain |
title_short | Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain |
title_sort | technological challenges in the development of optogenetic closed loop therapy approaches in epilepsy and related network disorders of the brain |
topic | optogenetics optrode brain epilepsy biocompatibility closed-loop therapy |
url | https://www.mdpi.com/2072-666X/12/1/38 |
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