Blood pressure dipping during REM and non-REM sleep in patients with moderate to severe obstructive sleep apnea
Abstract A limited number of papers have addressed the association between non-dipping-blood pressure (BP) obstructive sleep apnea (OSA), and no study has assessed BP-dipping during rapid eye movement (REM) and non-REM sleep in OSA patients. This study sought to noninvasively assess BP-dipping durin...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-87200-3 |
| _version_ | 1818844007886749696 |
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| author | Ahmed S. BaHammam Mana Alshahrani Salih A. Aleissi Awad H. Olaish Mohammed H. Alhassoon Afnan Shukr |
| author_facet | Ahmed S. BaHammam Mana Alshahrani Salih A. Aleissi Awad H. Olaish Mohammed H. Alhassoon Afnan Shukr |
| author_sort | Ahmed S. BaHammam |
| collection | DOAJ |
| description | Abstract A limited number of papers have addressed the association between non-dipping-blood pressure (BP) obstructive sleep apnea (OSA), and no study has assessed BP-dipping during rapid eye movement (REM) and non-REM sleep in OSA patients. This study sought to noninvasively assess BP-dipping during REM and non-REM (NREM)-sleep using a beat-by-beat measurement method (pulse-transit-time (PTT)). Thirty consecutive OSA patients (men = 50%) who had not been treated for OSA before and who had > 20-min of REM-sleep were included. During sleep, BP was indirectly determined via PTT. Patients were divided into dippers and non-dippers based on the average systolic-BP during REM and NREM-sleep. The studied group had a a median age of 50 (42–58.5) years and a body mass index of 33.8 (27.6–37.5) kg/m2. The median AHI of the study group was 32.6 (20.1–58.1) events/h (range: 7–124), and 89% of them had moderate-to-severe OSA. The prevalence of non-dippers during REM-sleep was 93.3%, and during NREM-sleep was 80%. During NREM sleep, non-dippers had a higher waist circumference and waist-hip-ratio, higher severity of OSA, longer-time spent with oxygen saturation < 90%, and a higher mean duration of apnea during REM and NREM-sleep. Severe OSA (AHI ≥ 30) was defined as an independent predictor of non-dipping BP during NREM sleep (OR = 19.5, CI: [1.299–292.75], p-value = 0.03). This short report demonstrated that BP-dipping occurs during REM and NREM-sleep in patients with moderate-to-severe OSA. There was a trend of more severe OSA among the non-dippers during NREM-sleep, and severe OSA was independently correlated with BP non-dipping during NREM sleep. |
| first_indexed | 2024-12-19T05:06:55Z |
| format | Article |
| id | doaj.art-6afb0f2d6f9c44e593d7f967a453598f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T05:06:55Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6afb0f2d6f9c44e593d7f967a453598f2022-12-21T20:34:54ZengNature PortfolioScientific Reports2045-23222021-04-011111910.1038/s41598-021-87200-3Blood pressure dipping during REM and non-REM sleep in patients with moderate to severe obstructive sleep apneaAhmed S. BaHammam0Mana Alshahrani1Salih A. Aleissi2Awad H. Olaish3Mohammed H. Alhassoon4Afnan Shukr5University Sleep Disorders Center, College of Medicine, King Saud UniversityUniversity Sleep Disorders Center, College of Medicine, King Saud UniversityUniversity Sleep Disorders Center, College of Medicine, King Saud UniversityUniversity Sleep Disorders Center, College of Medicine, King Saud UniversityUniversity Sleep Disorders Center, College of Medicine, King Saud UniversityUniversity Sleep Disorders Center, College of Medicine, King Saud UniversityAbstract A limited number of papers have addressed the association between non-dipping-blood pressure (BP) obstructive sleep apnea (OSA), and no study has assessed BP-dipping during rapid eye movement (REM) and non-REM sleep in OSA patients. This study sought to noninvasively assess BP-dipping during REM and non-REM (NREM)-sleep using a beat-by-beat measurement method (pulse-transit-time (PTT)). Thirty consecutive OSA patients (men = 50%) who had not been treated for OSA before and who had > 20-min of REM-sleep were included. During sleep, BP was indirectly determined via PTT. Patients were divided into dippers and non-dippers based on the average systolic-BP during REM and NREM-sleep. The studied group had a a median age of 50 (42–58.5) years and a body mass index of 33.8 (27.6–37.5) kg/m2. The median AHI of the study group was 32.6 (20.1–58.1) events/h (range: 7–124), and 89% of them had moderate-to-severe OSA. The prevalence of non-dippers during REM-sleep was 93.3%, and during NREM-sleep was 80%. During NREM sleep, non-dippers had a higher waist circumference and waist-hip-ratio, higher severity of OSA, longer-time spent with oxygen saturation < 90%, and a higher mean duration of apnea during REM and NREM-sleep. Severe OSA (AHI ≥ 30) was defined as an independent predictor of non-dipping BP during NREM sleep (OR = 19.5, CI: [1.299–292.75], p-value = 0.03). This short report demonstrated that BP-dipping occurs during REM and NREM-sleep in patients with moderate-to-severe OSA. There was a trend of more severe OSA among the non-dippers during NREM-sleep, and severe OSA was independently correlated with BP non-dipping during NREM sleep.https://doi.org/10.1038/s41598-021-87200-3 |
| spellingShingle | Ahmed S. BaHammam Mana Alshahrani Salih A. Aleissi Awad H. Olaish Mohammed H. Alhassoon Afnan Shukr Blood pressure dipping during REM and non-REM sleep in patients with moderate to severe obstructive sleep apnea Scientific Reports |
| title | Blood pressure dipping during REM and non-REM sleep in patients with moderate to severe obstructive sleep apnea |
| title_full | Blood pressure dipping during REM and non-REM sleep in patients with moderate to severe obstructive sleep apnea |
| title_fullStr | Blood pressure dipping during REM and non-REM sleep in patients with moderate to severe obstructive sleep apnea |
| title_full_unstemmed | Blood pressure dipping during REM and non-REM sleep in patients with moderate to severe obstructive sleep apnea |
| title_short | Blood pressure dipping during REM and non-REM sleep in patients with moderate to severe obstructive sleep apnea |
| title_sort | blood pressure dipping during rem and non rem sleep in patients with moderate to severe obstructive sleep apnea |
| url | https://doi.org/10.1038/s41598-021-87200-3 |
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