Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol
ABSTRACT Diarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of May...
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Academia Brasileira de Ciências
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401555&lng=en&tlng=en |
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| author | FERNANDO C. SILVA VANESSA G. RODRIGUES LUCIENIR P. DUARTE IVANA S. LULA RUBEN D. SINISTERRA SIDNEY A. VIEIRA-FILHO RODRIGO A.L. RODRIGUES ERNA G. KROON PATRÍCIA L. OLIVEIRA LUIZ M. FARIAS PAULA P. MAGALHÃES GRÁCIA D.F. SILVA |
| author_facet | FERNANDO C. SILVA VANESSA G. RODRIGUES LUCIENIR P. DUARTE IVANA S. LULA RUBEN D. SINISTERRA SIDNEY A. VIEIRA-FILHO RODRIGO A.L. RODRIGUES ERNA G. KROON PATRÍCIA L. OLIVEIRA LUIZ M. FARIAS PAULA P. MAGALHÃES GRÁCIA D.F. SILVA |
| author_sort | FERNANDO C. SILVA |
| collection | DOAJ |
| description | ABSTRACT Diarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of Maytenus genus, a phytochemical investigation followed by antibacterial activity test with extracts of branches and heartwood and bark of roots from Maytenus gonoclada were conducted. Moreover, due the frequency of isolation of lupeol from Maytenus genus the antiviral activity against Dengue virus and cytotoxicity of lupeol and its complex with β-cyclodextrins were also tested. The results indicated the bioactivity of ethyl acetate extract from branches and ethanol extract from heartwood of roots of M. gonoclada against diarrheagenic bacteria. The lupeol showed potent activity against Dengue virus and low cytotoxicity in LLC-MK2 cells, but its complex with β-cyclodextrin was inactive. Considering the importance of novel and selective antiviral drug candidates the results seem to be promising. |
| first_indexed | 2024-04-11T23:38:47Z |
| format | Article |
| id | doaj.art-6afb8fc06202419dadbd5524481ebc84 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-11T23:38:47Z |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-6afb8fc06202419dadbd5524481ebc842022-12-22T03:56:50ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26908931555156410.1590/0001-3765201720160046S0001-37652017000401555Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeolFERNANDO C. SILVAVANESSA G. RODRIGUESLUCIENIR P. DUARTEIVANA S. LULARUBEN D. SINISTERRASIDNEY A. VIEIRA-FILHORODRIGO A.L. RODRIGUESERNA G. KROONPATRÍCIA L. OLIVEIRALUIZ M. FARIASPAULA P. MAGALHÃESGRÁCIA D.F. SILVAABSTRACT Diarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of Maytenus genus, a phytochemical investigation followed by antibacterial activity test with extracts of branches and heartwood and bark of roots from Maytenus gonoclada were conducted. Moreover, due the frequency of isolation of lupeol from Maytenus genus the antiviral activity against Dengue virus and cytotoxicity of lupeol and its complex with β-cyclodextrins were also tested. The results indicated the bioactivity of ethyl acetate extract from branches and ethanol extract from heartwood of roots of M. gonoclada against diarrheagenic bacteria. The lupeol showed potent activity against Dengue virus and low cytotoxicity in LLC-MK2 cells, but its complex with β-cyclodextrin was inactive. Considering the importance of novel and selective antiviral drug candidates the results seem to be promising.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401555&lng=en&tlng=enAntidiarrhealCelastraceaePentacyclic TriterpeneAntiviral Activity |
| spellingShingle | FERNANDO C. SILVA VANESSA G. RODRIGUES LUCIENIR P. DUARTE IVANA S. LULA RUBEN D. SINISTERRA SIDNEY A. VIEIRA-FILHO RODRIGO A.L. RODRIGUES ERNA G. KROON PATRÍCIA L. OLIVEIRA LUIZ M. FARIAS PAULA P. MAGALHÃES GRÁCIA D.F. SILVA Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol Anais da Academia Brasileira de Ciências Antidiarrheal Celastraceae Pentacyclic Triterpene Antiviral Activity |
| title | Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol |
| title_full | Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol |
| title_fullStr | Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol |
| title_full_unstemmed | Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol |
| title_short | Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol |
| title_sort | antidiarrheal activity of extracts from maytenus gonoclada and inhibition of dengue virus by lupeol |
| topic | Antidiarrheal Celastraceae Pentacyclic Triterpene Antiviral Activity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401555&lng=en&tlng=en |
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