Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine
Bioengineering and reproductive medicine have progressed shoulder to shoulder for several decades. A key point of overlap is the development and clinical translation of technologies to support reproductive health, e.g., scaffold-free constructs, polymeric scaffolds, bioprinting or microfluidics, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/7/3765 |
| _version_ | 1797439000673255424 |
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| author | Emilio Francés-Herrero Adolfo Rodríguez-Eguren María Gómez-Álvarez Lucía de Miguel-Gómez Hortensia Ferrero Irene Cervelló |
| author_facet | Emilio Francés-Herrero Adolfo Rodríguez-Eguren María Gómez-Álvarez Lucía de Miguel-Gómez Hortensia Ferrero Irene Cervelló |
| author_sort | Emilio Francés-Herrero |
| collection | DOAJ |
| description | Bioengineering and reproductive medicine have progressed shoulder to shoulder for several decades. A key point of overlap is the development and clinical translation of technologies to support reproductive health, e.g., scaffold-free constructs, polymeric scaffolds, bioprinting or microfluidics, and hydrogels. Hydrogels are the focus of intense study, and those that are derived from the extracellular matrix (ECM) of reproductive tissues and organs are emerging as promising new players given their results in pre-clinical models. This literature review addresses the recent advances in the use of organ-specific ECM hydrogels in reproductive medicine, considering the entire female reproductive tract. We discuss in-depth papers describing the development of ECM hydrogels, their use in in vitro models, and their in vivo application in preclinical studies. We also summarize the functions of hydrogels, including as grafts, carriers for cell transplantation, or drug depots, and present the potential and possible scope for use of ECM hydrogels in the near future based on recent scientific advances. |
| first_indexed | 2024-03-09T11:46:30Z |
| format | Article |
| id | doaj.art-6afbddc54930496aa80f71d465070eea |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:46:30Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6afbddc54930496aa80f71d465070eea2023-11-30T23:21:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237376510.3390/ijms23073765Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive MedicineEmilio Francés-Herrero0Adolfo Rodríguez-Eguren1María Gómez-Álvarez2Lucía de Miguel-Gómez3Hortensia Ferrero4Irene Cervelló5Department of Pediatrics, Obstetrics and Gynecology, School of Medicine, University of Valencia, 46010 Valencia, SpainFundación IVI, IVI-RMA Global, 46026 Valencia, SpainFundación IVI, IVI-RMA Global, 46026 Valencia, SpainFundación IVI, IVI-RMA Global, 46026 Valencia, SpainFundación IVI, IVI-RMA Global, 46026 Valencia, SpainFundación IVI, IVI-RMA Global, 46026 Valencia, SpainBioengineering and reproductive medicine have progressed shoulder to shoulder for several decades. A key point of overlap is the development and clinical translation of technologies to support reproductive health, e.g., scaffold-free constructs, polymeric scaffolds, bioprinting or microfluidics, and hydrogels. Hydrogels are the focus of intense study, and those that are derived from the extracellular matrix (ECM) of reproductive tissues and organs are emerging as promising new players given their results in pre-clinical models. This literature review addresses the recent advances in the use of organ-specific ECM hydrogels in reproductive medicine, considering the entire female reproductive tract. We discuss in-depth papers describing the development of ECM hydrogels, their use in in vitro models, and their in vivo application in preclinical studies. We also summarize the functions of hydrogels, including as grafts, carriers for cell transplantation, or drug depots, and present the potential and possible scope for use of ECM hydrogels in the near future based on recent scientific advances.https://www.mdpi.com/1422-0067/23/7/3765bioengineeringECM hydrogelsreproductive medicinefemale tract |
| spellingShingle | Emilio Francés-Herrero Adolfo Rodríguez-Eguren María Gómez-Álvarez Lucía de Miguel-Gómez Hortensia Ferrero Irene Cervelló Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine International Journal of Molecular Sciences bioengineering ECM hydrogels reproductive medicine female tract |
| title | Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine |
| title_full | Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine |
| title_fullStr | Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine |
| title_full_unstemmed | Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine |
| title_short | Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine |
| title_sort | future challenges and opportunities of extracellular matrix hydrogels in female reproductive medicine |
| topic | bioengineering ECM hydrogels reproductive medicine female tract |
| url | https://www.mdpi.com/1422-0067/23/7/3765 |
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