Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry
Viruses have been re-engineered for many applications but the ability to build asymmetric capsids in vitro has been lacking. Here, the authors report the design of asymmetric subunits with different growth rates leading to capsids with discrete patches and potential for distinct surface chemistries.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20862-1 |
| _version_ | 1818428952362876928 |
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| author | Zhongchao Zhao Joseph Che-Yen Wang Mi Zhang Nicholas A. Lyktey Martin F. Jarrold Stephen C. Jacobson Adam Zlotnick |
| author_facet | Zhongchao Zhao Joseph Che-Yen Wang Mi Zhang Nicholas A. Lyktey Martin F. Jarrold Stephen C. Jacobson Adam Zlotnick |
| author_sort | Zhongchao Zhao |
| collection | DOAJ |
| description | Viruses have been re-engineered for many applications but the ability to build asymmetric capsids in vitro has been lacking. Here, the authors report the design of asymmetric subunits with different growth rates leading to capsids with discrete patches and potential for distinct surface chemistries. |
| first_indexed | 2024-12-14T15:09:48Z |
| format | Article |
| id | doaj.art-6afcd85b8a4d45b5bcb6913971ca9659 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T15:09:48Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6afcd85b8a4d45b5bcb6913971ca96592022-12-21T22:56:35ZengNature PortfolioNature Communications2041-17232021-01-0112111010.1038/s41467-020-20862-1Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetryZhongchao Zhao0Joseph Che-Yen Wang1Mi Zhang2Nicholas A. Lyktey3Martin F. Jarrold4Stephen C. Jacobson5Adam Zlotnick6Molecular and Cellular Biochemistry Department, Indiana UniversityMolecular and Cellular Biochemistry Department, Indiana UniversityDepartment of Chemistry, Indiana UniversityDepartment of Chemistry, Indiana UniversityDepartment of Chemistry, Indiana UniversityDepartment of Chemistry, Indiana UniversityMolecular and Cellular Biochemistry Department, Indiana UniversityViruses have been re-engineered for many applications but the ability to build asymmetric capsids in vitro has been lacking. Here, the authors report the design of asymmetric subunits with different growth rates leading to capsids with discrete patches and potential for distinct surface chemistries.https://doi.org/10.1038/s41467-020-20862-1 |
| spellingShingle | Zhongchao Zhao Joseph Che-Yen Wang Mi Zhang Nicholas A. Lyktey Martin F. Jarrold Stephen C. Jacobson Adam Zlotnick Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry Nature Communications |
| title | Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry |
| title_full | Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry |
| title_fullStr | Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry |
| title_full_unstemmed | Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry |
| title_short | Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry |
| title_sort | asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry |
| url | https://doi.org/10.1038/s41467-020-20862-1 |
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