Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease

Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease

Background: There is a significant gender difference in the incidence and symptoms of Alzheimer's disease (AD), but its mechanisms are not completely understood. Recent studies showed that NLRP1 inflammasome was overexpressed in females under some pathological conditions such as nodular melanom...

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Bibliographic Details
Main Authors: Jinghang Zhang, Lihong Pei, Dan Zang, Yun Xue, Xiaohui Wang, Yiyang Chen, Jinsong Li, Jian Yu, Qingzu Gao, Wenyu Di, Chaochu Cui, Wei Su, Xianwei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer's disease
NLRP1 inflammasome
gender differences
neuronal apoptosis
APP/PS1+/− mice
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2020.512097/full

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