In vivo-assessment of the human temporal network: Evidence for asymmetrical effective connectivity
The human temporal lobe is a multimodal association area which plays a key role in various aspects of cognition, particularly in memory formation and spatial navigation. Functional and anatomical connectivity of temporal structures is thus a subject of intense research, yet by far underexplored in h...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811920302561 |
| _version_ | 1818042979893379072 |
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| author | Yulia Novitskaya Matthias Dümpelmann Andreas Vlachos Peter Christoph Reinacher Andreas Schulze-Bonhage |
| author_facet | Yulia Novitskaya Matthias Dümpelmann Andreas Vlachos Peter Christoph Reinacher Andreas Schulze-Bonhage |
| author_sort | Yulia Novitskaya |
| collection | DOAJ |
| description | The human temporal lobe is a multimodal association area which plays a key role in various aspects of cognition, particularly in memory formation and spatial navigation. Functional and anatomical connectivity of temporal structures is thus a subject of intense research, yet by far underexplored in humans due to ethical and technical limitations. We assessed intratemporal cortico-cortical interactions in the living human brain by means of single pulse electrical stimulation, an invasive method allowing mapping effective intracortical connectivity with a high spatiotemporal resolution.Eighteen subjects with normal anterior-mesial temporal MR imaging undergoing intracranial presurgical epilepsy diagnostics with multiple depth electrodes were included. The investigated structures were temporal pole, hippocampus, amygdala and parahippocampal gyrus. Intratemporal cortical connectivity was assessed as a function of amplitude of the early component of the cortico-cortical evoked potentials (CCEP). While the analysis revealed robust interconnectivity between all explored structures, a clear asymmetry in bidirectional connectivity was detected for the hippocampal network and for the connections between the temporal pole and parahippocampal gyrus. The amygdala showed bidirectional asymmetry only to the hippocampus.The provided evidence of asymmetrically weighed intratemporal effective connectivity in humans in vivo is important for understanding of functional interactions within the temporal lobe since asymmetries in the brain connectivity define hierarchies in information processing. The findings are in exact accord with the anatomical tracing studies in non-human primates and open a translational route for interventions employing modulation of temporal lobe function. |
| first_indexed | 2024-12-10T08:54:56Z |
| format | Article |
| id | doaj.art-6afdb978bc09426186119bce3cdda0f9 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-10T08:54:56Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-6afdb978bc09426186119bce3cdda0f92022-12-22T01:55:27ZengElsevierNeuroImage1095-95722020-07-01214116769In vivo-assessment of the human temporal network: Evidence for asymmetrical effective connectivityYulia Novitskaya0Matthias Dümpelmann1Andreas Vlachos2Peter Christoph Reinacher3Andreas Schulze-Bonhage4Epilepsy Center, Department of Neurosurgery, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, 79106, Freiburg, Germany; Corresponding author.Epilepsy Center, Department of Neurosurgery, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, 79106, Freiburg, GermanyDepartment of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Albert Strasse 17, 79104, Freiburg, Germany; Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, 79106, Freiburg, GermanyDepartment of Stereotactic and Functional Neurosurgery, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, 79106, Freiburg, GermanyEpilepsy Center, Department of Neurosurgery, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, 79106, Freiburg, Germany; Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, 79106, Freiburg, GermanyThe human temporal lobe is a multimodal association area which plays a key role in various aspects of cognition, particularly in memory formation and spatial navigation. Functional and anatomical connectivity of temporal structures is thus a subject of intense research, yet by far underexplored in humans due to ethical and technical limitations. We assessed intratemporal cortico-cortical interactions in the living human brain by means of single pulse electrical stimulation, an invasive method allowing mapping effective intracortical connectivity with a high spatiotemporal resolution.Eighteen subjects with normal anterior-mesial temporal MR imaging undergoing intracranial presurgical epilepsy diagnostics with multiple depth electrodes were included. The investigated structures were temporal pole, hippocampus, amygdala and parahippocampal gyrus. Intratemporal cortical connectivity was assessed as a function of amplitude of the early component of the cortico-cortical evoked potentials (CCEP). While the analysis revealed robust interconnectivity between all explored structures, a clear asymmetry in bidirectional connectivity was detected for the hippocampal network and for the connections between the temporal pole and parahippocampal gyrus. The amygdala showed bidirectional asymmetry only to the hippocampus.The provided evidence of asymmetrically weighed intratemporal effective connectivity in humans in vivo is important for understanding of functional interactions within the temporal lobe since asymmetries in the brain connectivity define hierarchies in information processing. The findings are in exact accord with the anatomical tracing studies in non-human primates and open a translational route for interventions employing modulation of temporal lobe function.http://www.sciencedirect.com/science/article/pii/S1053811920302561Human temporal lobeCCEPEffective connectivityReciprocal connectivityAsymmetry |
| spellingShingle | Yulia Novitskaya Matthias Dümpelmann Andreas Vlachos Peter Christoph Reinacher Andreas Schulze-Bonhage In vivo-assessment of the human temporal network: Evidence for asymmetrical effective connectivity NeuroImage Human temporal lobe CCEP Effective connectivity Reciprocal connectivity Asymmetry |
| title | In vivo-assessment of the human temporal network: Evidence for asymmetrical effective connectivity |
| title_full | In vivo-assessment of the human temporal network: Evidence for asymmetrical effective connectivity |
| title_fullStr | In vivo-assessment of the human temporal network: Evidence for asymmetrical effective connectivity |
| title_full_unstemmed | In vivo-assessment of the human temporal network: Evidence for asymmetrical effective connectivity |
| title_short | In vivo-assessment of the human temporal network: Evidence for asymmetrical effective connectivity |
| title_sort | in vivo assessment of the human temporal network evidence for asymmetrical effective connectivity |
| topic | Human temporal lobe CCEP Effective connectivity Reciprocal connectivity Asymmetry |
| url | http://www.sciencedirect.com/science/article/pii/S1053811920302561 |
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