Epidermal Growth Factor Receptor Expression in Triple Negative and Nontriple Negative Breast Carcinomas
Introduction: The panel of markers used for molecular classification include estrogen receptors (ER), progesterone receptors (PR), human epidermal growth factor receptor (HER)-2/neu, p53, Bcl-2 and basal markers like cytokeratin 5/6 or epidermal growth factor receptor (EGFR). Among these, EGFR plays...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2015-07-01
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| Series: | Journal of Laboratory Physicians |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.163129 |
| _version_ | 1811335254611329024 |
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| author | Arathi A Changavi Arundhathi Shashikala Ashwini S Ramji |
| author_facet | Arathi A Changavi Arundhathi Shashikala Ashwini S Ramji |
| author_sort | Arathi A Changavi |
| collection | DOAJ |
| description | Introduction: The panel of markers used for molecular classification include estrogen receptors (ER), progesterone receptors (PR), human epidermal growth factor receptor (HER)-2/neu, p53, Bcl-2 and basal markers like cytokeratin 5/6 or epidermal growth factor receptor (EGFR). Among these, EGFR plays an important role and is associated with bad prognosis.
Aims and Objectives: To study EGFR expression in triple negative breast carcinoma (TNBC) and non-TNBCs (NTNBCs).
Materials and Methods: Fifty cases of breast carcinomas were classified and graded according to World Health Organization and Nottingham modification of Scarff-Bloom-Richardson (SBR) system, respectively. The age of the patients ranged from 28 to 69 years. Histological features such as necrosis, pushing borders, lymphocytic infiltrate and periductal elastosis were noted. The panel of markers used in our study included ER, PR, HER-2/neu and EGFR. EGFR expression was assessed based on membrane staining. Chi-square test was applied for statistical analysis to compare EGFR expression with hormonal status and prognostic factors. P < 0.05 was considered significant.
Results: The mean age was 49.8 ± 7.2 years. There were 44 (88%) infiltrating ductal carcinoma, 3 (6%) medullary carcinoma and 3 (6%) mucinous carcinoma. EGFR expression was common in young patients and was predominant in TNBC (89.47%), was also expressed in few cases of NTNBC. There was a positive correlation of EGFR expression (P = 0.03491) with a high grade. Medullary carcinomas were triple negative and strongly expressed EGFR. EGFR expression was inversely associated with ER status and showed strong association with necrosis and lymphocytic infiltrate, but not with pushing border and periductal elastosis.
Conclusion: EGFR is an important marker to stratify patients with breast cancer according to molecular classification. Its expression correlated positively with young age, higher SBR grade, necrosis, lymphocytic infiltrate and inversely with hormonal receptor expression. |
| first_indexed | 2024-04-13T17:21:30Z |
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| id | doaj.art-6aff1e9ab0ff471a90c83315aa22f3a9 |
| institution | Directory Open Access Journal |
| issn | 0974-2727 0974-7826 |
| language | English |
| last_indexed | 2024-04-13T17:21:30Z |
| publishDate | 2015-07-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Journal of Laboratory Physicians |
| spelling | doaj.art-6aff1e9ab0ff471a90c83315aa22f3a92022-12-22T02:37:57ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Laboratory Physicians0974-27270974-78262015-07-0170207908310.4103/0974-2727.163129Epidermal Growth Factor Receptor Expression in Triple Negative and Nontriple Negative Breast CarcinomasArathi A Changavi0Arundhathi Shashikala1Ashwini S Ramji2Department of Pathology, Sree Siddhartha Medical College, Tumkur, Karnataka, IndiaDepartment of Pathology, Sree Siddhartha Medical College, Tumkur, Karnataka, IndiaDepartment of Pathology, Sree Siddhartha Medical College, Tumkur, Karnataka, IndiaIntroduction: The panel of markers used for molecular classification include estrogen receptors (ER), progesterone receptors (PR), human epidermal growth factor receptor (HER)-2/neu, p53, Bcl-2 and basal markers like cytokeratin 5/6 or epidermal growth factor receptor (EGFR). Among these, EGFR plays an important role and is associated with bad prognosis. Aims and Objectives: To study EGFR expression in triple negative breast carcinoma (TNBC) and non-TNBCs (NTNBCs). Materials and Methods: Fifty cases of breast carcinomas were classified and graded according to World Health Organization and Nottingham modification of Scarff-Bloom-Richardson (SBR) system, respectively. The age of the patients ranged from 28 to 69 years. Histological features such as necrosis, pushing borders, lymphocytic infiltrate and periductal elastosis were noted. The panel of markers used in our study included ER, PR, HER-2/neu and EGFR. EGFR expression was assessed based on membrane staining. Chi-square test was applied for statistical analysis to compare EGFR expression with hormonal status and prognostic factors. P < 0.05 was considered significant. Results: The mean age was 49.8 ± 7.2 years. There were 44 (88%) infiltrating ductal carcinoma, 3 (6%) medullary carcinoma and 3 (6%) mucinous carcinoma. EGFR expression was common in young patients and was predominant in TNBC (89.47%), was also expressed in few cases of NTNBC. There was a positive correlation of EGFR expression (P = 0.03491) with a high grade. Medullary carcinomas were triple negative and strongly expressed EGFR. EGFR expression was inversely associated with ER status and showed strong association with necrosis and lymphocytic infiltrate, but not with pushing border and periductal elastosis. Conclusion: EGFR is an important marker to stratify patients with breast cancer according to molecular classification. Its expression correlated positively with young age, higher SBR grade, necrosis, lymphocytic infiltrate and inversely with hormonal receptor expression.http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.163129epidermal growth factor receptorhormonal statusnontriple negative breast carcinomatriple negative breast carcinoma |
| spellingShingle | Arathi A Changavi Arundhathi Shashikala Ashwini S Ramji Epidermal Growth Factor Receptor Expression in Triple Negative and Nontriple Negative Breast Carcinomas Journal of Laboratory Physicians epidermal growth factor receptor hormonal status nontriple negative breast carcinoma triple negative breast carcinoma |
| title | Epidermal Growth Factor Receptor Expression in Triple Negative and Nontriple Negative Breast Carcinomas |
| title_full | Epidermal Growth Factor Receptor Expression in Triple Negative and Nontriple Negative Breast Carcinomas |
| title_fullStr | Epidermal Growth Factor Receptor Expression in Triple Negative and Nontriple Negative Breast Carcinomas |
| title_full_unstemmed | Epidermal Growth Factor Receptor Expression in Triple Negative and Nontriple Negative Breast Carcinomas |
| title_short | Epidermal Growth Factor Receptor Expression in Triple Negative and Nontriple Negative Breast Carcinomas |
| title_sort | epidermal growth factor receptor expression in triple negative and nontriple negative breast carcinomas |
| topic | epidermal growth factor receptor hormonal status nontriple negative breast carcinoma triple negative breast carcinoma |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.163129 |
| work_keys_str_mv | AT arathiachangavi epidermalgrowthfactorreceptorexpressionintriplenegativeandnontriplenegativebreastcarcinomas AT arundhathishashikala epidermalgrowthfactorreceptorexpressionintriplenegativeandnontriplenegativebreastcarcinomas AT ashwinisramji epidermalgrowthfactorreceptorexpressionintriplenegativeandnontriplenegativebreastcarcinomas |