Fibroblast Activation Protein-Targeting Minibody-IRDye700DX for Ablation of the Cancer-Associated Fibroblast with Photodynamic Therapy

Fibroblast Activation Protein-Targeting Minibody-IRDye700DX for Ablation of the Cancer-Associated Fibroblast with Photodynamic Therapy

Fibroblast activation protein (FAP), expressed on cancer-associated fibroblasts, is a target for diagnosis and therapy in multiple tumour types. Strategies to systemically deplete FAP-expressing cells show efficacy; however, these induce toxicities, as FAP-expressing cells are found in normal tissue...

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Bibliographic Details
Main Authors: Esther M. M. Smeets, Daphne N. Dorst, Gerben M. Franssen, Merijn S. van Essen, Cathelijne Frielink, Martijn W. J. Stommel, Marija Trajkovic-Arsic, Phyllis F. Cheung, Jens T. Siveke, Ian Wilson, Alessandro Mascioni, Erik H. J. G. Aarntzen, Sanne A. M. van Lith
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
minibody
targeted photodynamic therapy (tPDT)
cancer-associated fibroblast (CAF)
fibroblast activation protein (FAP)
pancreatic ductal adenocarcinoma (PDAC)
Online Access:https://www.mdpi.com/2073-4409/12/10/1420

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