Long-term effect of acute ischemic injury on the kidney underwent clamped partial nephrectomy
Summary: GFR reaches a new baseline, primarily correlating with nephron-mass preservation, 1–12 months after partial nephrectomy (PN). However, does the ipsilateral GFR experience subsequent decline, and does acute ischemic injury has long-term effect on the operated kidney? 319 patients with two ki...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223016875 |
| _version_ | 1827860172130746368 |
|---|---|
| author | Zhaohui Zhou Zhiyong Li Kang Ning Longbin Xiong Huiming Liu Yixin Huang Xin Luo Yulu Peng Lijie Chen Binglei Ma Xiangpeng Zou Wensu Wei Cheng Luo Hui Han Shengjie Guo Pei Dong Fangjian Zhou Chunping Yu Zhiling Zhang |
| author_facet | Zhaohui Zhou Zhiyong Li Kang Ning Longbin Xiong Huiming Liu Yixin Huang Xin Luo Yulu Peng Lijie Chen Binglei Ma Xiangpeng Zou Wensu Wei Cheng Luo Hui Han Shengjie Guo Pei Dong Fangjian Zhou Chunping Yu Zhiling Zhang |
| author_sort | Zhaohui Zhou |
| collection | DOAJ |
| description | Summary: GFR reaches a new baseline, primarily correlating with nephron-mass preservation, 1–12 months after partial nephrectomy (PN). However, does the ipsilateral GFR experience subsequent decline, and does acute ischemic injury has long-term effect on the operated kidney? 319 patients with two kidneys and unilateral clamped PN were analyzed. All had preoperative, new-baseline, and latest follow-up imaging/serum creatinine levels. Annual ipsilateral GFR decline rate (AIGDR) was defined as new-baseline GFR minus latest follow-up GFR normalized by new-baseline GFR, per year. Spectrum score was used to reflect the degree of acute ischemic injury in the operated kidney. 100 subjects searching for health screening served as controls. Predictive factors for AIGDR were assessed. The median AIGDR was 2.25%, significantly higher than controls (0.88%, p = 0.036). With some contralateral hypertrophy, the global annual GFR decline was similar to that of controls (0.81% vs. 0.88%, p = 0.7). Spectrum score correlated significantly with AIGDR (p = 0.037). These results support that acute ischemic injury has long-term effect on the operated kidney. |
| first_indexed | 2024-03-12T13:19:25Z |
| format | Article |
| id | doaj.art-6aff62155b3c4eb6bde0a50fd8925a3b |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T13:19:25Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-6aff62155b3c4eb6bde0a50fd8925a3b2023-08-26T04:43:57ZengElsevieriScience2589-00422023-09-01269107610Long-term effect of acute ischemic injury on the kidney underwent clamped partial nephrectomyZhaohui Zhou0Zhiyong Li1Kang Ning2Longbin Xiong3Huiming Liu4Yixin Huang5Xin Luo6Yulu Peng7Lijie Chen8Binglei Ma9Xiangpeng Zou10Wensu Wei11Cheng Luo12Hui Han13Shengjie Guo14Pei Dong15Fangjian Zhou16Chunping Yu17Zhiling Zhang18Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Anesthesiology, Sun Yat-Sen University Cancer Center, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaGuangdong Key Laboratory of Urology, Department of Urology, Minimally Invasive Surgery Center, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Urology, Guangzhou, China; Corresponding authorDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Corresponding authorSummary: GFR reaches a new baseline, primarily correlating with nephron-mass preservation, 1–12 months after partial nephrectomy (PN). However, does the ipsilateral GFR experience subsequent decline, and does acute ischemic injury has long-term effect on the operated kidney? 319 patients with two kidneys and unilateral clamped PN were analyzed. All had preoperative, new-baseline, and latest follow-up imaging/serum creatinine levels. Annual ipsilateral GFR decline rate (AIGDR) was defined as new-baseline GFR minus latest follow-up GFR normalized by new-baseline GFR, per year. Spectrum score was used to reflect the degree of acute ischemic injury in the operated kidney. 100 subjects searching for health screening served as controls. Predictive factors for AIGDR were assessed. The median AIGDR was 2.25%, significantly higher than controls (0.88%, p = 0.036). With some contralateral hypertrophy, the global annual GFR decline was similar to that of controls (0.81% vs. 0.88%, p = 0.7). Spectrum score correlated significantly with AIGDR (p = 0.037). These results support that acute ischemic injury has long-term effect on the operated kidney.http://www.sciencedirect.com/science/article/pii/S2589004223016875EndocrinologyPublic healthPathophysiologyMedical endocrinology |
| spellingShingle | Zhaohui Zhou Zhiyong Li Kang Ning Longbin Xiong Huiming Liu Yixin Huang Xin Luo Yulu Peng Lijie Chen Binglei Ma Xiangpeng Zou Wensu Wei Cheng Luo Hui Han Shengjie Guo Pei Dong Fangjian Zhou Chunping Yu Zhiling Zhang Long-term effect of acute ischemic injury on the kidney underwent clamped partial nephrectomy iScience Endocrinology Public health Pathophysiology Medical endocrinology |
| title | Long-term effect of acute ischemic injury on the kidney underwent clamped partial nephrectomy |
| title_full | Long-term effect of acute ischemic injury on the kidney underwent clamped partial nephrectomy |
| title_fullStr | Long-term effect of acute ischemic injury on the kidney underwent clamped partial nephrectomy |
| title_full_unstemmed | Long-term effect of acute ischemic injury on the kidney underwent clamped partial nephrectomy |
| title_short | Long-term effect of acute ischemic injury on the kidney underwent clamped partial nephrectomy |
| title_sort | long term effect of acute ischemic injury on the kidney underwent clamped partial nephrectomy |
| topic | Endocrinology Public health Pathophysiology Medical endocrinology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223016875 |
| work_keys_str_mv | AT zhaohuizhou longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT zhiyongli longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT kangning longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT longbinxiong longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT huimingliu longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT yixinhuang longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT xinluo longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT yulupeng longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT lijiechen longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT bingleima longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT xiangpengzou longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT wensuwei longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT chengluo longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT huihan longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT shengjieguo longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT peidong longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT fangjianzhou longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT chunpingyu longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy AT zhilingzhang longtermeffectofacuteischemicinjuryonthekidneyunderwentclampedpartialnephrectomy |