Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells.

Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells.

Embryonic development can be partially recapitulated in vitro by differentiating human embryonic stem cells (hESCs). Thalidomide is a developmental toxicant in vivo and acts in a species-dependent manner. Besides its therapeutic value, thalidomide also serves as a prototypical model to study teratog...

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Main Authors: Kesavan Meganathan, Smita Jagtap, Vilas Wagh, Johannes Winkler, John Antonydas Gaspar, Diana Hildebrand, Maria Trusch, Karola Lehmann, Jürgen Hescheler, Hartmut Schlüter, Agapios Sachinidis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3429450?pdf=render

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