Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications
Peptide molecules have design flexibility, self-assembly ability, high biocompatibility, good biodegradability, and easy functionalization, which promote their applications as versatile biomaterials for tissue engineering and biomedicine. In addition, the functionalization of self-assembled peptide...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2024-05-01
|
| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24000331 |
| _version_ | 1797235539141722112 |
|---|---|
| author | Rongqiu Mu Danzhu Zhu Sama Abdulmalik Suranji Wijekoon Gang Wei Sangamesh G. Kumbar |
| author_facet | Rongqiu Mu Danzhu Zhu Sama Abdulmalik Suranji Wijekoon Gang Wei Sangamesh G. Kumbar |
| author_sort | Rongqiu Mu |
| collection | DOAJ |
| description | Peptide molecules have design flexibility, self-assembly ability, high biocompatibility, good biodegradability, and easy functionalization, which promote their applications as versatile biomaterials for tissue engineering and biomedicine. In addition, the functionalization of self-assembled peptide nanomaterials with other additive components enhances their stimuli-responsive functions, promoting function-specific applications that induced by both internal and external stimulations. In this review, we demonstrate recent advance in the peptide molecular design, self-assembly, functional tailoring, and biomedical applications of peptide-based nanomaterials. The strategies on the design and synthesis of single, dual, and multiple stimuli-responsive peptide-based nanomaterials with various dimensions are analyzed, and the functional regulation of peptide nanomaterials with active components such as metal/metal oxide, DNA/RNA, polysaccharides, photosensitizers, 2D materials, and others are discussed. In addition, the designed peptide-based nanomaterials with temperature-, pH-, ion-, light-, enzyme-, and ROS-responsive abilities for drug delivery, bioimaging, cancer therapy, gene therapy, antibacterial, as well as wound healing and dressing applications are presented and discussed. This comprehensive review provides detailed methodologies and advanced techniques on the synthesis of peptide nanomaterials from molecular biology, materials science, and nanotechnology, which will guide and inspire the molecular level design of peptides with specific and multiple functions for function-specific applications. |
| first_indexed | 2024-03-08T06:54:03Z |
| format | Article |
| id | doaj.art-6b014caace334dc69f6de3b03876fe1c |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T16:49:34Z |
| publishDate | 2024-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-6b014caace334dc69f6de3b03876fe1c2024-03-29T05:50:53ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2024-05-0135181207Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applicationsRongqiu Mu0Danzhu Zhu1Sama Abdulmalik2Suranji Wijekoon3Gang Wei4Sangamesh G. Kumbar5College of Chemistry and Chemical Engineering, Qingdao University, 266071, Qingdao, ChinaCollege of Chemistry and Chemical Engineering, Qingdao University, 266071, Qingdao, ChinaDepartment of Orthopaedic Surgery, University of Connecticut Health, Farmington, 06030, USADepartment of Orthopaedic Surgery, University of Connecticut Health, Farmington, 06030, USACollege of Chemistry and Chemical Engineering, Qingdao University, 266071, Qingdao, China; Corresponding author.Department of Biomedical Engineering & Department of Materials Science and Engineering, University of Connecticut, Storrs, 06269, USA; Department of Orthopaedic Surgery, University of Connecticut Health, Farmington, 06030, USA; Corresponding author. Department of Biomedical Engineering & Department of Materials Science and Engineering, University of Connecticut, Storrs, 06269, USA.Peptide molecules have design flexibility, self-assembly ability, high biocompatibility, good biodegradability, and easy functionalization, which promote their applications as versatile biomaterials for tissue engineering and biomedicine. In addition, the functionalization of self-assembled peptide nanomaterials with other additive components enhances their stimuli-responsive functions, promoting function-specific applications that induced by both internal and external stimulations. In this review, we demonstrate recent advance in the peptide molecular design, self-assembly, functional tailoring, and biomedical applications of peptide-based nanomaterials. The strategies on the design and synthesis of single, dual, and multiple stimuli-responsive peptide-based nanomaterials with various dimensions are analyzed, and the functional regulation of peptide nanomaterials with active components such as metal/metal oxide, DNA/RNA, polysaccharides, photosensitizers, 2D materials, and others are discussed. In addition, the designed peptide-based nanomaterials with temperature-, pH-, ion-, light-, enzyme-, and ROS-responsive abilities for drug delivery, bioimaging, cancer therapy, gene therapy, antibacterial, as well as wound healing and dressing applications are presented and discussed. This comprehensive review provides detailed methodologies and advanced techniques on the synthesis of peptide nanomaterials from molecular biology, materials science, and nanotechnology, which will guide and inspire the molecular level design of peptides with specific and multiple functions for function-specific applications.http://www.sciencedirect.com/science/article/pii/S2452199X24000331Peptide assembliesMolecular designFunctional modulationStimuli-responsive nanomaterialsBiomedical applications |
| spellingShingle | Rongqiu Mu Danzhu Zhu Sama Abdulmalik Suranji Wijekoon Gang Wei Sangamesh G. Kumbar Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications Bioactive Materials Peptide assemblies Molecular design Functional modulation Stimuli-responsive nanomaterials Biomedical applications |
| title | Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications |
| title_full | Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications |
| title_fullStr | Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications |
| title_full_unstemmed | Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications |
| title_short | Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications |
| title_sort | stimuli responsive peptide assemblies design self assembly modulation and biomedical applications |
| topic | Peptide assemblies Molecular design Functional modulation Stimuli-responsive nanomaterials Biomedical applications |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24000331 |
| work_keys_str_mv | AT rongqiumu stimuliresponsivepeptideassembliesdesignselfassemblymodulationandbiomedicalapplications AT danzhuzhu stimuliresponsivepeptideassembliesdesignselfassemblymodulationandbiomedicalapplications AT samaabdulmalik stimuliresponsivepeptideassembliesdesignselfassemblymodulationandbiomedicalapplications AT suranjiwijekoon stimuliresponsivepeptideassembliesdesignselfassemblymodulationandbiomedicalapplications AT gangwei stimuliresponsivepeptideassembliesdesignselfassemblymodulationandbiomedicalapplications AT sangameshgkumbar stimuliresponsivepeptideassembliesdesignselfassemblymodulationandbiomedicalapplications |