Chimeric Antigen Receptor, Teamwork, Education, Assessment, and Management (CAR-TEAM): A Simulation-Based Inter-professional Education (IPE) Intervention for Management of CAR Toxicities
Chimeric antigen receptor (CAR) therapies such as tisagenlecleucel, indicated for children and young adults with relapsed and/or refractory CD19+ acute lymphoblastic leukemia (ALL), have been associated with striking treatment outcomes and overall survival. Yet, they are also associated with unique...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.01227/full |
| _version_ | 1819168556619661312 |
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| author | Avis Harden Dristhi Ragoonanan Daryl Anildes-Gubman David McCall Kathleen Faltus Sarah Featherston Basirat Shoberu Jerelyn R. Moffet Demetrios Petropoulos Sajad J. Khazal Shehla Razvi Kris M. Mahadeo Priti Tewari |
| author_facet | Avis Harden Dristhi Ragoonanan Daryl Anildes-Gubman David McCall Kathleen Faltus Sarah Featherston Basirat Shoberu Jerelyn R. Moffet Demetrios Petropoulos Sajad J. Khazal Shehla Razvi Kris M. Mahadeo Priti Tewari |
| author_sort | Avis Harden |
| collection | DOAJ |
| description | Chimeric antigen receptor (CAR) therapies such as tisagenlecleucel, indicated for children and young adults with relapsed and/or refractory CD19+ acute lymphoblastic leukemia (ALL), have been associated with striking treatment outcomes and overall survival. Yet, they are also associated with unique and potentially life-threatening complications. Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) are generally reversible complications of CAR therapies, but many patients may require critical care support especially if they are not promptly recognized and appropriately managed by frontline healthcare staff. As CAR therapies become more widely available, it is important that inter-professional staff members be aware of general principles regarding diagnosis and management. We hypothesized that an inter-professional education (IPE) simulation-based education intervention (CAR-TEAM) would improve knowledge base and confidence regarding complications of CAR therapies among inter-professional staff. Here, we demonstrate that following CAR-TEAM training, >90% of participants demonstrated knowledge proficiency and confidence in the IPE content area. CAR-TEAM training may serve as an important tool to establish initial and continued competency among sites introducing CAR therapies. |
| first_indexed | 2024-12-22T19:05:29Z |
| format | Article |
| id | doaj.art-6b030ac93a1b4942927d8216844f199d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T19:05:29Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-6b030ac93a1b4942927d8216844f199d2022-12-21T18:15:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-08-011010.3389/fonc.2020.01227555516Chimeric Antigen Receptor, Teamwork, Education, Assessment, and Management (CAR-TEAM): A Simulation-Based Inter-professional Education (IPE) Intervention for Management of CAR ToxicitiesAvis Harden0Dristhi Ragoonanan1Daryl Anildes-Gubman2David McCall3Kathleen Faltus4Sarah Featherston5Basirat Shoberu6Jerelyn R. Moffet7Demetrios Petropoulos8Sajad J. Khazal9Shehla Razvi10Kris M. Mahadeo11Priti Tewari12Department of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX, United StatesTeaching, Interprofessional and Simulation Education Center, University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDivision of Blood and Marrow Transplant, Department of Pediatrics, Duke Children's Hospital, Duke University, Durham, NC, United StatesDepartment of Pediatrics, CARTOX Program, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Pediatrics, CARTOX Program, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Pediatrics, CARTOX Program, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Pediatrics, CARTOX Program, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesChimeric antigen receptor (CAR) therapies such as tisagenlecleucel, indicated for children and young adults with relapsed and/or refractory CD19+ acute lymphoblastic leukemia (ALL), have been associated with striking treatment outcomes and overall survival. Yet, they are also associated with unique and potentially life-threatening complications. Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) are generally reversible complications of CAR therapies, but many patients may require critical care support especially if they are not promptly recognized and appropriately managed by frontline healthcare staff. As CAR therapies become more widely available, it is important that inter-professional staff members be aware of general principles regarding diagnosis and management. We hypothesized that an inter-professional education (IPE) simulation-based education intervention (CAR-TEAM) would improve knowledge base and confidence regarding complications of CAR therapies among inter-professional staff. Here, we demonstrate that following CAR-TEAM training, >90% of participants demonstrated knowledge proficiency and confidence in the IPE content area. CAR-TEAM training may serve as an important tool to establish initial and continued competency among sites introducing CAR therapies.https://www.frontiersin.org/article/10.3389/fonc.2020.01227/fullinter-professionaleducationsimulation-basedcytokine release syndrome (CRS)immune effector cell-associated neurotoxicity (ICANS) |
| spellingShingle | Avis Harden Dristhi Ragoonanan Daryl Anildes-Gubman David McCall Kathleen Faltus Sarah Featherston Basirat Shoberu Jerelyn R. Moffet Demetrios Petropoulos Sajad J. Khazal Shehla Razvi Kris M. Mahadeo Priti Tewari Chimeric Antigen Receptor, Teamwork, Education, Assessment, and Management (CAR-TEAM): A Simulation-Based Inter-professional Education (IPE) Intervention for Management of CAR Toxicities Frontiers in Oncology inter-professional education simulation-based cytokine release syndrome (CRS) immune effector cell-associated neurotoxicity (ICANS) |
| title | Chimeric Antigen Receptor, Teamwork, Education, Assessment, and Management (CAR-TEAM): A Simulation-Based Inter-professional Education (IPE) Intervention for Management of CAR Toxicities |
| title_full | Chimeric Antigen Receptor, Teamwork, Education, Assessment, and Management (CAR-TEAM): A Simulation-Based Inter-professional Education (IPE) Intervention for Management of CAR Toxicities |
| title_fullStr | Chimeric Antigen Receptor, Teamwork, Education, Assessment, and Management (CAR-TEAM): A Simulation-Based Inter-professional Education (IPE) Intervention for Management of CAR Toxicities |
| title_full_unstemmed | Chimeric Antigen Receptor, Teamwork, Education, Assessment, and Management (CAR-TEAM): A Simulation-Based Inter-professional Education (IPE) Intervention for Management of CAR Toxicities |
| title_short | Chimeric Antigen Receptor, Teamwork, Education, Assessment, and Management (CAR-TEAM): A Simulation-Based Inter-professional Education (IPE) Intervention for Management of CAR Toxicities |
| title_sort | chimeric antigen receptor teamwork education assessment and management car team a simulation based inter professional education ipe intervention for management of car toxicities |
| topic | inter-professional education simulation-based cytokine release syndrome (CRS) immune effector cell-associated neurotoxicity (ICANS) |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.01227/full |
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