Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3
Single nucleotide polymorphisms (SNPs) in the ADGRL3 gene have been significantly associated with the development of ADHD, the aetiology of which remains poorly understood. The rs1397547 SNP has additionally been associated with significantly altered ADGRL3 transcription. We therefore generated iPSC...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506123000028 |
| _version_ | 1797897301102952448 |
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| author | Rhiannon V. McNeill Franziska Radtke Matthias Nieberler Carolin Koreny Andreas G. Chiocchetti Sarah Kittel-Schneider |
| author_facet | Rhiannon V. McNeill Franziska Radtke Matthias Nieberler Carolin Koreny Andreas G. Chiocchetti Sarah Kittel-Schneider |
| author_sort | Rhiannon V. McNeill |
| collection | DOAJ |
| description | Single nucleotide polymorphisms (SNPs) in the ADGRL3 gene have been significantly associated with the development of ADHD, the aetiology of which remains poorly understood. The rs1397547 SNP has additionally been associated with significantly altered ADGRL3 transcription. We therefore generated iPSCs from two wild type ADHD patients, and two ADHD patients heterozygous for the risk SNP. With this resource we aim to facilitate further investigation into the complex and heterogenous pathology of ADHD. Furthermore, we demonstrate the feasibility of using magnetic activated cell sorting to allow the unbiased selection of fully reprogrammed iPSCs. |
| first_indexed | 2024-04-10T07:55:22Z |
| format | Article |
| id | doaj.art-6b032637119d4118804098eb7392b7b3 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-04-10T07:55:22Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-6b032637119d4118804098eb7392b7b32023-02-23T04:30:51ZengElsevierStem Cell Research1873-50612023-03-0167103016Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3Rhiannon V. McNeill0Franziska Radtke1Matthias Nieberler2Carolin Koreny3Andreas G. Chiocchetti4Sarah Kittel-Schneider5Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, D-97080 Würzburg, Germany; Corresponding author.Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, D-97080 Würzburg, GermanyDepartment of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, D-97080 Würzburg, GermanyDepartment of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, D-97080 Würzburg, GermanyDepartment of Child and Adolescent Psychiatry and Psychotherapy, Goethe University Frankfurt, Frankfurt am Main, GermanyDepartment of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Würzburg, D-97080 Würzburg, Germany; Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital Frankfurt, Frankfurt, GermanySingle nucleotide polymorphisms (SNPs) in the ADGRL3 gene have been significantly associated with the development of ADHD, the aetiology of which remains poorly understood. The rs1397547 SNP has additionally been associated with significantly altered ADGRL3 transcription. We therefore generated iPSCs from two wild type ADHD patients, and two ADHD patients heterozygous for the risk SNP. With this resource we aim to facilitate further investigation into the complex and heterogenous pathology of ADHD. Furthermore, we demonstrate the feasibility of using magnetic activated cell sorting to allow the unbiased selection of fully reprogrammed iPSCs.http://www.sciencedirect.com/science/article/pii/S1873506123000028 |
| spellingShingle | Rhiannon V. McNeill Franziska Radtke Matthias Nieberler Carolin Koreny Andreas G. Chiocchetti Sarah Kittel-Schneider Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3 Stem Cell Research |
| title | Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3 |
| title_full | Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3 |
| title_fullStr | Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3 |
| title_full_unstemmed | Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3 |
| title_short | Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3 |
| title_sort | generation of four human induced pluripotent stem cells derived from adhd patients carrying different genotypes for the risk snp rs1397547 in the adhd associated gene adgrl3 |
| url | http://www.sciencedirect.com/science/article/pii/S1873506123000028 |
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