Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products

Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products

In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pina...

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Bibliographic Details
Main Authors: Md. Saiful Islam, Muhammad Zubair, Iftikhar Hussain Bukhari, Asma Yaqoob, Umer Rashid, Shazia Kousar, Faiz-ul-Hassan Nasim, Mnaza Noreen, Nasir Rasool, Yasmeen Gull
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Molecules
Subjects:
Suzuki cross coupling
benzothiazoles
urease activity
nitric oxide scavenging activity
Online Access:http://www.mdpi.com/1420-3049/18/8/8845
Description
Summary:In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC50 value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100µg/mL.
ISSN:1420-3049

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