Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products
In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pina...
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MDPI AG
2013-07-01
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author | Md. Saiful Islam Muhammad Zubair Iftikhar Hussain Bukhari Asma Yaqoob Umer Rashid Shazia Kousar Faiz-ul-Hassan Nasim Mnaza Noreen Nasir Rasool Yasmeen Gull |
author_facet | Md. Saiful Islam Muhammad Zubair Iftikhar Hussain Bukhari Asma Yaqoob Umer Rashid Shazia Kousar Faiz-ul-Hassan Nasim Mnaza Noreen Nasir Rasool Yasmeen Gull |
author_sort | Md. Saiful Islam |
collection | DOAJ |
description | In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC50 value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100µg/mL. |
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issn | 1420-3049 |
language | English |
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publishDate | 2013-07-01 |
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series | Molecules |
spelling | doaj.art-6b03ed0a8e9040c28d7c7a88397995c02022-12-22T02:52:34ZengMDPI AGMolecules1420-30492013-07-011888845885710.3390/molecules18088845Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the ProductsMd. Saiful IslamMuhammad ZubairIftikhar Hussain BukhariAsma YaqoobUmer RashidShazia KousarFaiz-ul-Hassan NasimMnaza NoreenNasir RasoolYasmeen GullIn general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC50 value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100µg/mL.http://www.mdpi.com/1420-3049/18/8/8845Suzuki cross couplingbenzothiazolesurease activitynitric oxide scavenging activity |
spellingShingle | Md. Saiful Islam Muhammad Zubair Iftikhar Hussain Bukhari Asma Yaqoob Umer Rashid Shazia Kousar Faiz-ul-Hassan Nasim Mnaza Noreen Nasir Rasool Yasmeen Gull Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products Molecules Suzuki cross coupling benzothiazoles urease activity nitric oxide scavenging activity |
title | Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products |
title_full | Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products |
title_fullStr | Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products |
title_full_unstemmed | Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products |
title_short | Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products |
title_sort | efficient synthesis of 2 amino 6 arylbenzothiazoles via pd 0 suzuki cross coupling reactions potent urease enzyme inhibition and nitric oxide scavenging activities of the products |
topic | Suzuki cross coupling benzothiazoles urease activity nitric oxide scavenging activity |
url | http://www.mdpi.com/1420-3049/18/8/8845 |
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