DNA Methylation Changes in Blood Cells of Fibromyalgia and Chronic Fatigue Syndrome Patients
Patrycja Kamila Przybylowicz, Katarzyna Ewa Sokolowska, Hubert Rola, Tomasz Kazimierz Wojdacz Independent Clinical Epigenetics Laboratory, Pomeranian Medical University, Szczecin, PolandCorrespondence: Tomasz Kazimierz Wojdacz, Independent Clinical Epigenetics Laboratory, Pomeranian Medical Universi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-11-01
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| Series: | Journal of Pain Research |
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| Online Access: | https://www.dovepress.com/dna-methylation-changes-in-blood-cells-of-fibromyalgia-and-chronic-fat-peer-reviewed-fulltext-article-JPR |
| _version_ | 1797447397879578624 |
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| author | Przybylowicz PK Sokolowska KE Rola H Wojdacz TK |
| author_facet | Przybylowicz PK Sokolowska KE Rola H Wojdacz TK |
| author_sort | Przybylowicz PK |
| collection | DOAJ |
| description | Patrycja Kamila Przybylowicz, Katarzyna Ewa Sokolowska, Hubert Rola, Tomasz Kazimierz Wojdacz Independent Clinical Epigenetics Laboratory, Pomeranian Medical University, Szczecin, PolandCorrespondence: Tomasz Kazimierz Wojdacz, Independent Clinical Epigenetics Laboratory, Pomeranian Medical University, Unii Lubelskiej 1, Szczecin, 71-252, Poland, Tel +48 91 44 17 201, Email tomasz.wojdacz@pum.edu.plPurpose: Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS) affect 0.4% and 1% of society, respectively, and the prevalence of these pain syndromes is increasing. To date, no strong association between these syndromes and the genetic background of affected individuals has been shown. Therefore, it is plausible that epigenetic changes might play a role in the development of these syndromes.Patients and Methods: Three previous studies have attempted to elaborate the involvement of genome-wide methylation changes in blood cells in the development of fibromyalgia and chronic fatigue syndrome. These studies included 22 patients with fibromyalgia and 127 patients with CFS, and the results of the studies were largely discrepant. Contradicting results of those studies may be attributed to differences in the omics data analysis approaches used in each study. We reanalyzed the data collected in these studies using an updated and coherent data-analysis framework.Results: Overall, the methylation changes that we observed overlapped with previous results only to some extent. However, the gene set enrichment analyses based on genes annotated to methylation changes identified in each of the analyzed datasets were surprisingly coherent and uniformly associated with the physiological processes that, when affected, may result in symptoms characteristic of fibromyalgia and chronic fatigue syndrome.Conclusion: Methylomes of the blood cells of patients with FM and CFS in three independent studies have shown methylation changes that appear to be implicated in the pathogenesis of these syndromes.Keywords: epigenetics, chronic pain, microarray studies, cytosine methylation |
| first_indexed | 2024-03-09T13:55:01Z |
| format | Article |
| id | doaj.art-6b043aafa59440fd816ebf85ba9541f6 |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-03-09T13:55:01Z |
| publishDate | 2023-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-6b043aafa59440fd816ebf85ba9541f62023-11-30T18:44:06ZengDove Medical PressJournal of Pain Research1178-70902023-11-01Volume 164025403688601DNA Methylation Changes in Blood Cells of Fibromyalgia and Chronic Fatigue Syndrome PatientsPrzybylowicz PKSokolowska KERola HWojdacz TKPatrycja Kamila Przybylowicz, Katarzyna Ewa Sokolowska, Hubert Rola, Tomasz Kazimierz Wojdacz Independent Clinical Epigenetics Laboratory, Pomeranian Medical University, Szczecin, PolandCorrespondence: Tomasz Kazimierz Wojdacz, Independent Clinical Epigenetics Laboratory, Pomeranian Medical University, Unii Lubelskiej 1, Szczecin, 71-252, Poland, Tel +48 91 44 17 201, Email tomasz.wojdacz@pum.edu.plPurpose: Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS) affect 0.4% and 1% of society, respectively, and the prevalence of these pain syndromes is increasing. To date, no strong association between these syndromes and the genetic background of affected individuals has been shown. Therefore, it is plausible that epigenetic changes might play a role in the development of these syndromes.Patients and Methods: Three previous studies have attempted to elaborate the involvement of genome-wide methylation changes in blood cells in the development of fibromyalgia and chronic fatigue syndrome. These studies included 22 patients with fibromyalgia and 127 patients with CFS, and the results of the studies were largely discrepant. Contradicting results of those studies may be attributed to differences in the omics data analysis approaches used in each study. We reanalyzed the data collected in these studies using an updated and coherent data-analysis framework.Results: Overall, the methylation changes that we observed overlapped with previous results only to some extent. However, the gene set enrichment analyses based on genes annotated to methylation changes identified in each of the analyzed datasets were surprisingly coherent and uniformly associated with the physiological processes that, when affected, may result in symptoms characteristic of fibromyalgia and chronic fatigue syndrome.Conclusion: Methylomes of the blood cells of patients with FM and CFS in three independent studies have shown methylation changes that appear to be implicated in the pathogenesis of these syndromes.Keywords: epigenetics, chronic pain, microarray studies, cytosine methylationhttps://www.dovepress.com/dna-methylation-changes-in-blood-cells-of-fibromyalgia-and-chronic-fat-peer-reviewed-fulltext-article-JPRepigeneticschronic painmicroarray studiescytosine methylation |
| spellingShingle | Przybylowicz PK Sokolowska KE Rola H Wojdacz TK DNA Methylation Changes in Blood Cells of Fibromyalgia and Chronic Fatigue Syndrome Patients Journal of Pain Research epigenetics chronic pain microarray studies cytosine methylation |
| title | DNA Methylation Changes in Blood Cells of Fibromyalgia and Chronic Fatigue Syndrome Patients |
| title_full | DNA Methylation Changes in Blood Cells of Fibromyalgia and Chronic Fatigue Syndrome Patients |
| title_fullStr | DNA Methylation Changes in Blood Cells of Fibromyalgia and Chronic Fatigue Syndrome Patients |
| title_full_unstemmed | DNA Methylation Changes in Blood Cells of Fibromyalgia and Chronic Fatigue Syndrome Patients |
| title_short | DNA Methylation Changes in Blood Cells of Fibromyalgia and Chronic Fatigue Syndrome Patients |
| title_sort | dna methylation changes in blood cells of fibromyalgia and chronic fatigue syndrome patients |
| topic | epigenetics chronic pain microarray studies cytosine methylation |
| url | https://www.dovepress.com/dna-methylation-changes-in-blood-cells-of-fibromyalgia-and-chronic-fat-peer-reviewed-fulltext-article-JPR |
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