Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems.
Hepatitis C virus (HCV) is an important cause of chronic liver disease. Several highly diverse HCV genotypes exist with potential key functional differences. The HCV NS5A protein was associated with response to interferon (IFN)-α based therapy, and is a primary target of currently developed directly...
Main Authors: | Troels K H Scheel, Jannick Prentoe, Thomas H R Carlsen, Lotte S Mikkelsen, Judith M Gottwein, Jens Bukh |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS Pathogens |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22654662/pdf/?tool=EBI |
Similar Items
-
Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry
by: Jannick Prentoe, et al.
Published: (2018-09-01) -
Productive homologous and non-homologous recombination of hepatitis C virus in cell culture.
by: Troels K H Scheel, et al.
Published: (2013-03-01) -
In vitro adaptation and characterization of attenuated hypervariable region 1 swap chimeras of hepatitis C virus.
by: Christina Holmboe Olesen, et al.
Published: (2021-07-01) -
Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A.
by: Rodrigo Velázquez-Moctezuma, et al.
Published: (2017-02-01) -
Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells.
by: Saeed, M, et al.
Published: (2012)