Genetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genotyping findings of cytochrome-alleles in the North Indian population

Genetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genotyping findings of cytochrome-alleles in the North Indian population

Abstract Background This research aims to study the association of genetic polymorphism in genes coding for CYP2C9 and CYP2C19 in phenytoin-induced dose-related toxicity and to assess if the presence of allele CYP2C9*3 plays a role in phenytoin-induced idiosyncratic adverse effects. Current observat...

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Bibliographic Details
Main Authors: Vivek Kumar Garg, Supriya, Ritu Shree, Ajay Prakash, Aastha Takkar, Madhu Khullar, Biman Saikia, Bikash Medhi, Manish Modi
Format: Article
Language:English
Published: SpringerOpen 2022-10-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Epilepsy
CYP2C9
Phenytoin
Adverse drug reaction
Online Access:https://doi.org/10.1186/s43094-022-00432-6

Internet

https://doi.org/10.1186/s43094-022-00432-6

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