Transcriptional upregulation of MAPK15 by NF-κB signaling boosts the efficacy of combination therapy with cisplatin and TNF-α

Transcriptional upregulation of MAPK15 by NF-κB signaling boosts the efficacy of combination therapy with cisplatin and TNF-α

Summary: The efficacy of cisplatin in treating advanced non-small cell lung cancer is limited mainly because of insensitivity and/or acquired resistance. MAPK15, previously shown by us to enhance the sensitivity of the anti-cancer drug arsenic trioxide, could also enhance the sensitivity of other an...

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Bibliographic Details
Main Authors: Dan-Dan Wu, Li-Juan Dai, Heng Wee Tan, Xiao-Yun Zhao, Qi-Yao Wei, Qiu-Hua Zhong, Yan-Chen Ji, Xiao-Hui Yin, Fei-Yuan Yu, Dong-Yan Jin, Sheng-Qing Li, Andy T.Y. Lau, Yan-Ming Xu
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Molecular mechanism of gene regulation
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422201731X

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