Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner
Background: PET imaging after yttrium-90 (Y-90) radioembolization is challenging because of the low positron fraction of Y-90 (32 × 10<sup>−6</sup>). The resulting low number of events can be compensated by the high sensitivity of long axial field-of-view (LAFOV) PET/CT scanners. Neverth...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/22/3418 |
| _version_ | 1797459606629253120 |
|---|---|
| author | Pia M. Linder Wenhong Lan Nils F. Trautwein Julia Brosch-Lenz Sebastian von Beschwitz Jürgen Kupferschläger Gerald Reischl Gerd Grözinger Helmut Dittmann Christian la Fougère Fabian P. Schmidt |
| author_facet | Pia M. Linder Wenhong Lan Nils F. Trautwein Julia Brosch-Lenz Sebastian von Beschwitz Jürgen Kupferschläger Gerald Reischl Gerd Grözinger Helmut Dittmann Christian la Fougère Fabian P. Schmidt |
| author_sort | Pia M. Linder |
| collection | DOAJ |
| description | Background: PET imaging after yttrium-90 (Y-90) radioembolization is challenging because of the low positron fraction of Y-90 (32 × 10<sup>−6</sup>). The resulting low number of events can be compensated by the high sensitivity of long axial field-of-view (LAFOV) PET/CT scanners. Nevertheless, the reduced event statistics require optimization of the imaging protocol to achieve high image quality (IQ) and quantification accuracy sufficient for post-treatment dosimetry. Methods: Two phantoms (NEMA IEC and AbdoMan phantoms, mimicking human liver) filled with Y-90 and a 4:1 sphere (tumor)-to-background ratio were scanned for 24 h with the Biograph Vision Quadra (Siemens Healthineers). Eight patients were scanned after Y-90 radioembolization (1.3–4.7 GBq) using the optimized protocol (obtained by phantom studies). The IQ, contrast recovery coefficients (CRCs) and noise were evaluated for their limited and full acceptance angles, different rebinned scan durations, numbers of iterations and post-reconstruction filters. The s-value-based absorbed doses were calculated to assess their suitability for dosimetry. Results: The phantom studies demonstrate that two iterations, five subsets and a 4 mm Gaussian filter provide a reasonable compromise between a high CRC and low noise. For a 20 min scan duration, an adequate CRC of 56% (vs. 24 h: 62%, 20 mm sphere) was obtained, and the noise was reduced by a factor of 1.4, from 40% to 29%, using the full acceptance angle. The patient scan results were consistent with those from the phantom studies, and the impacts on the absorbed doses were negligible for all of the studied parameter sets, as the maximum percentage difference was −3.89%. Conclusions: With 2i5s, a 4 mm filter and a scan duration of 20 min, IQ and quantification accuracy that are suitable for post-treatment dosimetry of Y-90 radioembolization can be achieved. |
| first_indexed | 2024-03-09T16:53:47Z |
| format | Article |
| id | doaj.art-6b0a73105f26449a845a235dfe0d17ca |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T16:53:47Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6b0a73105f26449a845a235dfe0d17ca2023-11-24T14:37:31ZengMDPI AGDiagnostics2075-44182023-11-011322341810.3390/diagnostics13223418Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT ScannerPia M. Linder0Wenhong Lan1Nils F. Trautwein2Julia Brosch-Lenz3Sebastian von Beschwitz4Jürgen Kupferschläger5Gerald Reischl6Gerd Grözinger7Helmut Dittmann8Christian la Fougère9Fabian P. Schmidt10Department of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, 72076 Tuebingen, GermanyDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, 72076 Tuebingen, GermanyDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, 72076 Tuebingen, GermanyDepartment of Nuclear Medicine, Klinikum Rechts der Isar, Technical University Munich, 81675 Munich, GermanyDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, 72076 Tuebingen, GermanyDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, 72076 Tuebingen, GermanyWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard-Karls University Tuebingen, 72074 Tuebingen, GermanyDepartment for Diagnostic and Interventional Radiology, University Hospital Tuebingen, 72076 Tuebingen, GermanyDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, 72076 Tuebingen, GermanyDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, 72076 Tuebingen, GermanyDepartment of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, 72076 Tuebingen, GermanyBackground: PET imaging after yttrium-90 (Y-90) radioembolization is challenging because of the low positron fraction of Y-90 (32 × 10<sup>−6</sup>). The resulting low number of events can be compensated by the high sensitivity of long axial field-of-view (LAFOV) PET/CT scanners. Nevertheless, the reduced event statistics require optimization of the imaging protocol to achieve high image quality (IQ) and quantification accuracy sufficient for post-treatment dosimetry. Methods: Two phantoms (NEMA IEC and AbdoMan phantoms, mimicking human liver) filled with Y-90 and a 4:1 sphere (tumor)-to-background ratio were scanned for 24 h with the Biograph Vision Quadra (Siemens Healthineers). Eight patients were scanned after Y-90 radioembolization (1.3–4.7 GBq) using the optimized protocol (obtained by phantom studies). The IQ, contrast recovery coefficients (CRCs) and noise were evaluated for their limited and full acceptance angles, different rebinned scan durations, numbers of iterations and post-reconstruction filters. The s-value-based absorbed doses were calculated to assess their suitability for dosimetry. Results: The phantom studies demonstrate that two iterations, five subsets and a 4 mm Gaussian filter provide a reasonable compromise between a high CRC and low noise. For a 20 min scan duration, an adequate CRC of 56% (vs. 24 h: 62%, 20 mm sphere) was obtained, and the noise was reduced by a factor of 1.4, from 40% to 29%, using the full acceptance angle. The patient scan results were consistent with those from the phantom studies, and the impacts on the absorbed doses were negligible for all of the studied parameter sets, as the maximum percentage difference was −3.89%. Conclusions: With 2i5s, a 4 mm filter and a scan duration of 20 min, IQ and quantification accuracy that are suitable for post-treatment dosimetry of Y-90 radioembolization can be achieved.https://www.mdpi.com/2075-4418/13/22/3418PET/CTSIRTradioembolizationY90total body PETLAFOV |
| spellingShingle | Pia M. Linder Wenhong Lan Nils F. Trautwein Julia Brosch-Lenz Sebastian von Beschwitz Jürgen Kupferschläger Gerald Reischl Gerd Grözinger Helmut Dittmann Christian la Fougère Fabian P. Schmidt Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner Diagnostics PET/CT SIRT radioembolization Y90 total body PET LAFOV |
| title | Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner |
| title_full | Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner |
| title_fullStr | Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner |
| title_full_unstemmed | Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner |
| title_short | Optimization of Y-90 Radioembolization Imaging for Post-Treatment Dosimetry on a Long Axial Field-of-View PET/CT Scanner |
| title_sort | optimization of y 90 radioembolization imaging for post treatment dosimetry on a long axial field of view pet ct scanner |
| topic | PET/CT SIRT radioembolization Y90 total body PET LAFOV |
| url | https://www.mdpi.com/2075-4418/13/22/3418 |
| work_keys_str_mv | AT piamlinder optimizationofy90radioembolizationimagingforposttreatmentdosimetryonalongaxialfieldofviewpetctscanner AT wenhonglan optimizationofy90radioembolizationimagingforposttreatmentdosimetryonalongaxialfieldofviewpetctscanner AT nilsftrautwein optimizationofy90radioembolizationimagingforposttreatmentdosimetryonalongaxialfieldofviewpetctscanner AT juliabroschlenz optimizationofy90radioembolizationimagingforposttreatmentdosimetryonalongaxialfieldofviewpetctscanner AT sebastianvonbeschwitz optimizationofy90radioembolizationimagingforposttreatmentdosimetryonalongaxialfieldofviewpetctscanner AT jurgenkupferschlager optimizationofy90radioembolizationimagingforposttreatmentdosimetryonalongaxialfieldofviewpetctscanner AT geraldreischl optimizationofy90radioembolizationimagingforposttreatmentdosimetryonalongaxialfieldofviewpetctscanner AT gerdgrozinger optimizationofy90radioembolizationimagingforposttreatmentdosimetryonalongaxialfieldofviewpetctscanner AT helmutdittmann optimizationofy90radioembolizationimagingforposttreatmentdosimetryonalongaxialfieldofviewpetctscanner AT christianlafougere optimizationofy90radioembolizationimagingforposttreatmentdosimetryonalongaxialfieldofviewpetctscanner AT fabianpschmidt optimizationofy90radioembolizationimagingforposttreatmentdosimetryonalongaxialfieldofviewpetctscanner |