Cabazitaxel-induced stabilization of microtubules enhances radiosensitivity in ovarian cancer cells

Cabazitaxel-induced stabilization of microtubules enhances radiosensitivity in ovarian cancer cells

Background: Up to 40% of women with ovarian cancer have short disease-free intervals due to molecular mechanisms of chemotherapy resistance. New therapeutic strategies are sought. Ovarian cancers are sensitive to radiochemotherapy. The taxane cabazitaxel (XRP6258, Jevtana) promotes tubulin assembly...

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Bibliographic Details
Main Authors: Charles eKunos, Tammy eStefan, James William Jacobberger
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Oncology
Subjects:
Radiation
ovarian cancer
Cabazitaxel
radiosensitivity
Jevtana
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00226/full

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