Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia.
Although the exact pathophysiology of preeclampsia is not fully understood, several elemental micronutrient abnormalities have been suggested to play a contributory role in preeclampsia.To investigate the levels of calcium, magnesium, zinc and copper in women with preeclampsia.A case-control study w...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5135106?pdf=render |
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| author | Abdelmageed Elmugabil Hamdan Z Hamdan Anas E Elsheikh Duria A Rayis Ishag Adam Gasim I Gasim |
| author_facet | Abdelmageed Elmugabil Hamdan Z Hamdan Anas E Elsheikh Duria A Rayis Ishag Adam Gasim I Gasim |
| author_sort | Abdelmageed Elmugabil |
| collection | DOAJ |
| description | Although the exact pathophysiology of preeclampsia is not fully understood, several elemental micronutrient abnormalities have been suggested to play a contributory role in preeclampsia.To investigate the levels of calcium, magnesium, zinc and copper in women with preeclampsia.A case-control study was conducted in Omdurman Maternity Hospital, Sudan, during the period of September through December 2014. The cases were women with preeclampsia while healthy pregnant women were the controls. The medical and obstetrics history was gathered using questionnaires. The serum levels of calcium, magnesium, zinc and copper were measured using atomic absorption spectrophotometer.There was no significant difference between the two groups in their age, gestational age, parity and body mass index. Zinc and copper levels were not significantly different between the two groups. In comparison with the controls, women with preeclampsia had a significantly lower median (inter-quartile) serum calcium [7.6 (4.0─9.6) vs. 8.1 (10.6─14.2), mg/dl, P = 0.032] and higher levels of magnesium [1.9 (1.4─2.5) vs. 1.4 (1.0─1.9) mg/dl; P = 0.003]. In binary logistic regression, lower calcium (OR = 0.73, 95% CI = 0.56 ─ 0.95, P = 0.021) and higher magnesium (OR = 5.724, 95% CI = 1.23 ─ 26.50, P = 0.026) levels were associated with preeclampsia. There were no significant correlations between levels of hemoglobin and these trace elements.The current study showed significant associations between preeclampsia and serum levels of calcium and magnesium. |
| first_indexed | 2024-12-11T22:27:39Z |
| format | Article |
| id | doaj.art-6b0e52d65f834ece95fd875ecf841968 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T22:27:39Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6b0e52d65f834ece95fd875ecf8419682022-12-22T00:48:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016749510.1371/journal.pone.0167495Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia.Abdelmageed ElmugabilHamdan Z HamdanAnas E ElsheikhDuria A RayisIshag AdamGasim I GasimAlthough the exact pathophysiology of preeclampsia is not fully understood, several elemental micronutrient abnormalities have been suggested to play a contributory role in preeclampsia.To investigate the levels of calcium, magnesium, zinc and copper in women with preeclampsia.A case-control study was conducted in Omdurman Maternity Hospital, Sudan, during the period of September through December 2014. The cases were women with preeclampsia while healthy pregnant women were the controls. The medical and obstetrics history was gathered using questionnaires. The serum levels of calcium, magnesium, zinc and copper were measured using atomic absorption spectrophotometer.There was no significant difference between the two groups in their age, gestational age, parity and body mass index. Zinc and copper levels were not significantly different between the two groups. In comparison with the controls, women with preeclampsia had a significantly lower median (inter-quartile) serum calcium [7.6 (4.0─9.6) vs. 8.1 (10.6─14.2), mg/dl, P = 0.032] and higher levels of magnesium [1.9 (1.4─2.5) vs. 1.4 (1.0─1.9) mg/dl; P = 0.003]. In binary logistic regression, lower calcium (OR = 0.73, 95% CI = 0.56 ─ 0.95, P = 0.021) and higher magnesium (OR = 5.724, 95% CI = 1.23 ─ 26.50, P = 0.026) levels were associated with preeclampsia. There were no significant correlations between levels of hemoglobin and these trace elements.The current study showed significant associations between preeclampsia and serum levels of calcium and magnesium.http://europepmc.org/articles/PMC5135106?pdf=render |
| spellingShingle | Abdelmageed Elmugabil Hamdan Z Hamdan Anas E Elsheikh Duria A Rayis Ishag Adam Gasim I Gasim Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia. PLoS ONE |
| title | Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia. |
| title_full | Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia. |
| title_fullStr | Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia. |
| title_full_unstemmed | Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia. |
| title_short | Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia. |
| title_sort | serum calcium magnesium zinc and copper levels in sudanese women with preeclampsia |
| url | http://europepmc.org/articles/PMC5135106?pdf=render |
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