Choreographing the double strand break response: Ubiquitin and SUMO control of nuclear architecture
The cellular response to DNA double strand breaks (DSBs) is a multifaceted signaling program that centers on post-translational modifications including phosphorylation, ubiquitylation and SUMOylation. In this review we discuss how ubiquitin and SUMO orchestrate the recognition of DSBs and explore ho...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-06-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00103/full |
| _version_ | 1819262167276322816 |
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| author | Shane M Harding Roger A Greenberg |
| author_facet | Shane M Harding Roger A Greenberg |
| author_sort | Shane M Harding |
| collection | DOAJ |
| description | The cellular response to DNA double strand breaks (DSBs) is a multifaceted signaling program that centers on post-translational modifications including phosphorylation, ubiquitylation and SUMOylation. In this review we discuss how ubiquitin and SUMO orchestrate the recognition of DSBs and explore how this influences chromatin organization. We discuss functional outcomes of this response including transcriptional silencing and how pre-existing chromatin states may control the DSB response and the maintenance of genomic stability. |
| first_indexed | 2024-12-23T19:53:23Z |
| format | Article |
| id | doaj.art-6b0f88f23e154a3390a0d458b5a981d4 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-23T19:53:23Z |
| publishDate | 2016-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-6b0f88f23e154a3390a0d458b5a981d42022-12-21T17:33:19ZengFrontiers Media S.A.Frontiers in Genetics1664-80212016-06-01710.3389/fgene.2016.00103195052Choreographing the double strand break response: Ubiquitin and SUMO control of nuclear architectureShane M Harding0Roger A Greenberg1University of PennsylvaniaUniversity of PennsylvaniaThe cellular response to DNA double strand breaks (DSBs) is a multifaceted signaling program that centers on post-translational modifications including phosphorylation, ubiquitylation and SUMOylation. In this review we discuss how ubiquitin and SUMO orchestrate the recognition of DSBs and explore how this influences chromatin organization. We discuss functional outcomes of this response including transcriptional silencing and how pre-existing chromatin states may control the DSB response and the maintenance of genomic stability.http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00103/fullTelomereUbiquitinSUMOdouble-strand break repairRAP80 |
| spellingShingle | Shane M Harding Roger A Greenberg Choreographing the double strand break response: Ubiquitin and SUMO control of nuclear architecture Frontiers in Genetics Telomere Ubiquitin SUMO double-strand break repair RAP80 |
| title | Choreographing the double strand break response: Ubiquitin and SUMO control of nuclear architecture |
| title_full | Choreographing the double strand break response: Ubiquitin and SUMO control of nuclear architecture |
| title_fullStr | Choreographing the double strand break response: Ubiquitin and SUMO control of nuclear architecture |
| title_full_unstemmed | Choreographing the double strand break response: Ubiquitin and SUMO control of nuclear architecture |
| title_short | Choreographing the double strand break response: Ubiquitin and SUMO control of nuclear architecture |
| title_sort | choreographing the double strand break response ubiquitin and sumo control of nuclear architecture |
| topic | Telomere Ubiquitin SUMO double-strand break repair RAP80 |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00103/full |
| work_keys_str_mv | AT shanemharding choreographingthedoublestrandbreakresponseubiquitinandsumocontrolofnucleararchitecture AT rogeragreenberg choreographingthedoublestrandbreakresponseubiquitinandsumocontrolofnucleararchitecture |