Effects of Sub therapeutic Doses of ACE-I in Improving insulin sensitivity in Type II DM Patients
Diabetes mellitus (DM) is a complex, multifactorial and heterogeneous group of disorders characterized by endogenous insulin deficiency and/or insulin resistance. Regardless of the etiology, the disease manifests itself as a state of chronic hyperglycemia with attendant small blood vessel (microvasc...
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| Format: | Article |
| Language: | English |
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University of Anbar
2014-04-01
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| Series: | مجلة جامعة الانبار للعلوم الصرفة |
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| Online Access: | https://juaps.uoanbar.edu.iq/article_121393_d41d8cd98f00b204e9800998ecf8427e.pdf |
| _version_ | 1797373273250463744 |
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| author | Nesren Sh. Mohammed Saad A. Hussain Isam Noori Ai-Karwi |
| author_facet | Nesren Sh. Mohammed Saad A. Hussain Isam Noori Ai-Karwi |
| author_sort | Nesren Sh. Mohammed |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a complex, multifactorial and heterogeneous group of disorders characterized by endogenous insulin deficiency and/or insulin resistance. Regardless of the etiology, the disease manifests itself as a state of chronic hyperglycemia with attendant small blood vessel (microvascular) and large blood vessel (macrovascular) complications, All individuals who have DM have derangement of normal blood glucose and insulin homeostasis. Insulin receptor defects (quantitative and/or qualitative) inhibit glucose uptake by cells as in type 2 diabetes mellitus (T2DM). While Beta cell failure results in inadequate circulating insulin levels as in type 1 diabetes mellitus (T1DM). 30 patients selected with uncontrolled non insulin dependent diabetes mellitus (NIDDM) .Their average age was (44.34±7.15) years and their duration of diabetes was 8.48±8.27 years,examination and selection of patients done by the consultant physician ,assistant professor ,at the national center of treatment and research for diabetes .Essential kidney disease and hypertensive patients were excluded, we tested their blood pressure, fasting blood sugar (FBS),post postprandial glucose excursion (PPGE) and albuminuria before and after daily captopril intake for 2 months.The results showed a significant decrease (p<0.01) in PPGE (postprandial glucose excursion) , after taking angiotensin converting enzyme (ACE) inhibitor captopril mean (185 ±28.75 mg/dl) when compared before captopril intake (230±45 mg/dl) , when calculating the area under the curve. In which these results indicated a positive effect of captopril on insulin sensitivity and blood glucose level. |
| first_indexed | 2024-03-08T18:48:04Z |
| format | Article |
| id | doaj.art-6b0feb1133724833af22ed841ba6aa68 |
| institution | Directory Open Access Journal |
| issn | 1991-8941 2706-6703 |
| language | English |
| last_indexed | 2024-03-08T18:48:04Z |
| publishDate | 2014-04-01 |
| publisher | University of Anbar |
| record_format | Article |
| series | مجلة جامعة الانبار للعلوم الصرفة |
| spelling | doaj.art-6b0feb1133724833af22ed841ba6aa682023-12-28T21:57:17ZengUniversity of Anbarمجلة جامعة الانبار للعلوم الصرفة1991-89412706-67032014-04-0181141810.37652/juaps.2014.121393121393Effects of Sub therapeutic Doses of ACE-I in Improving insulin sensitivity in Type II DM PatientsNesren Sh. Mohammed0Saad A. Hussain1Isam Noori Ai-Karwi2College of Pharmacy,University of Baghdad-Iraq.College of Pharmacy,University of Baghdad-Iraq.National Center for Diabetes ,Al-Mustansriya universityDiabetes mellitus (DM) is a complex, multifactorial and heterogeneous group of disorders characterized by endogenous insulin deficiency and/or insulin resistance. Regardless of the etiology, the disease manifests itself as a state of chronic hyperglycemia with attendant small blood vessel (microvascular) and large blood vessel (macrovascular) complications, All individuals who have DM have derangement of normal blood glucose and insulin homeostasis. Insulin receptor defects (quantitative and/or qualitative) inhibit glucose uptake by cells as in type 2 diabetes mellitus (T2DM). While Beta cell failure results in inadequate circulating insulin levels as in type 1 diabetes mellitus (T1DM). 30 patients selected with uncontrolled non insulin dependent diabetes mellitus (NIDDM) .Their average age was (44.34±7.15) years and their duration of diabetes was 8.48±8.27 years,examination and selection of patients done by the consultant physician ,assistant professor ,at the national center of treatment and research for diabetes .Essential kidney disease and hypertensive patients were excluded, we tested their blood pressure, fasting blood sugar (FBS),post postprandial glucose excursion (PPGE) and albuminuria before and after daily captopril intake for 2 months.The results showed a significant decrease (p<0.01) in PPGE (postprandial glucose excursion) , after taking angiotensin converting enzyme (ACE) inhibitor captopril mean (185 ±28.75 mg/dl) when compared before captopril intake (230±45 mg/dl) , when calculating the area under the curve. In which these results indicated a positive effect of captopril on insulin sensitivity and blood glucose level.https://juaps.uoanbar.edu.iq/article_121393_d41d8cd98f00b204e9800998ecf8427e.pdfaceimproving insulin sensitivitytype ii dm patients |
| spellingShingle | Nesren Sh. Mohammed Saad A. Hussain Isam Noori Ai-Karwi Effects of Sub therapeutic Doses of ACE-I in Improving insulin sensitivity in Type II DM Patients مجلة جامعة الانبار للعلوم الصرفة ace improving insulin sensitivity type ii dm patients |
| title | Effects of Sub therapeutic Doses of ACE-I in Improving insulin sensitivity in Type II DM Patients |
| title_full | Effects of Sub therapeutic Doses of ACE-I in Improving insulin sensitivity in Type II DM Patients |
| title_fullStr | Effects of Sub therapeutic Doses of ACE-I in Improving insulin sensitivity in Type II DM Patients |
| title_full_unstemmed | Effects of Sub therapeutic Doses of ACE-I in Improving insulin sensitivity in Type II DM Patients |
| title_short | Effects of Sub therapeutic Doses of ACE-I in Improving insulin sensitivity in Type II DM Patients |
| title_sort | effects of sub therapeutic doses of ace i in improving insulin sensitivity in type ii dm patients |
| topic | ace improving insulin sensitivity type ii dm patients |
| url | https://juaps.uoanbar.edu.iq/article_121393_d41d8cd98f00b204e9800998ecf8427e.pdf |
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