Ketamine versus Tramadol for Analgesia in Spontaneous Vaginal Delivery: A Randomized Clinical Trial
Background: The outcome of spontaneous vaginal birth is improved using analgesics during the three phases of labour. Both pharmaceutical and non-pharmaceutical approaches have been tried. Therefore, this study aimed to compare parenteral ketamine and tramadol regarding their analgesic effect and mat...
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| Format: | Article |
| Language: | English |
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Al-Azhar University, Faculty of Medicine (Damietta)
2023-08-01
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| Series: | International Journal of Medical Arts |
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| Online Access: | https://ijma.journals.ekb.eg/article_316791_b2812e695938784f2e6baec4a30fd931.pdf |
| _version_ | 1797364437180481536 |
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| author | Khaled Elsheshtawy |
| author_facet | Khaled Elsheshtawy |
| author_sort | Khaled Elsheshtawy |
| collection | DOAJ |
| description | Background: The outcome of spontaneous vaginal birth is improved using analgesics during the three phases of labour. Both pharmaceutical and non-pharmaceutical approaches have been tried. Therefore, this study aimed to compare parenteral ketamine and tramadol regarding their analgesic effect and maternal and labor outcome.Patients and Methods: This randomized clinical trial was conducted on 100 primigravida and multigravida women. The study population was randomized into two equal groups; ketamine group: received low dose ketamine 0.4 mg/kg body weight intravenous [IV] slowly over 30-60 seconds with maintenance dose at the rate of 1 mg/min in normal saline after 30 min of induction dose using an infusion pump and the tramadol group: 1 mg/kg iv slowly for 5-10 minutes then after 30 min we start maintenance by IV Tramadol 0.3 mg /kg/hr.Results: Ketamine significantly decreased the time of onset analgesia [p=0.036] and VAS [p=0.002] than tramadol. Ketamine has a significant advance in patient satisfaction than tramadol. The duration of all 3 stages of labor, Apgar score after 1 min, Apgar score after 5 min, and the percentage of maternal complications did not exhibit any significant change between both groups.Conclusion: In spontaneous vaginal delivery, ketamine and tramadol are considered safe drugs with low complications and similar Apgar scores after 1 min and also after 5 min with superiority of ketamine than tramadol regarding the earlier time of onset analgesia, lower VAS score and better patient satisfaction. |
| first_indexed | 2024-03-08T16:35:19Z |
| format | Article |
| id | doaj.art-6b1172fb2e534b6498390ed53a3ae7a7 |
| institution | Directory Open Access Journal |
| issn | 2636-4174 2682-3780 |
| language | English |
| last_indexed | 2024-03-08T16:35:19Z |
| publishDate | 2023-08-01 |
| publisher | Al-Azhar University, Faculty of Medicine (Damietta) |
| record_format | Article |
| series | International Journal of Medical Arts |
| spelling | doaj.art-6b1172fb2e534b6498390ed53a3ae7a72024-01-05T19:33:34ZengAl-Azhar University, Faculty of Medicine (Damietta)International Journal of Medical Arts2636-41742682-37802023-08-01583495350010.21608/ijma.2023.214270.1696316791Ketamine versus Tramadol for Analgesia in Spontaneous Vaginal Delivery: A Randomized Clinical TrialKhaled Elsheshtawy0Department of Anesthesia and Intensive care, Faculty of Medicine, Al-Azhar University, Cairo, EgyptBackground: The outcome of spontaneous vaginal birth is improved using analgesics during the three phases of labour. Both pharmaceutical and non-pharmaceutical approaches have been tried. Therefore, this study aimed to compare parenteral ketamine and tramadol regarding their analgesic effect and maternal and labor outcome.Patients and Methods: This randomized clinical trial was conducted on 100 primigravida and multigravida women. The study population was randomized into two equal groups; ketamine group: received low dose ketamine 0.4 mg/kg body weight intravenous [IV] slowly over 30-60 seconds with maintenance dose at the rate of 1 mg/min in normal saline after 30 min of induction dose using an infusion pump and the tramadol group: 1 mg/kg iv slowly for 5-10 minutes then after 30 min we start maintenance by IV Tramadol 0.3 mg /kg/hr.Results: Ketamine significantly decreased the time of onset analgesia [p=0.036] and VAS [p=0.002] than tramadol. Ketamine has a significant advance in patient satisfaction than tramadol. The duration of all 3 stages of labor, Apgar score after 1 min, Apgar score after 5 min, and the percentage of maternal complications did not exhibit any significant change between both groups.Conclusion: In spontaneous vaginal delivery, ketamine and tramadol are considered safe drugs with low complications and similar Apgar scores after 1 min and also after 5 min with superiority of ketamine than tramadol regarding the earlier time of onset analgesia, lower VAS score and better patient satisfaction.https://ijma.journals.ekb.eg/article_316791_b2812e695938784f2e6baec4a30fd931.pdfketaminetramadolanalgesiaspontaneous vaginal delivery |
| spellingShingle | Khaled Elsheshtawy Ketamine versus Tramadol for Analgesia in Spontaneous Vaginal Delivery: A Randomized Clinical Trial International Journal of Medical Arts ketamine tramadol analgesia spontaneous vaginal delivery |
| title | Ketamine versus Tramadol for Analgesia in Spontaneous Vaginal Delivery: A Randomized Clinical Trial |
| title_full | Ketamine versus Tramadol for Analgesia in Spontaneous Vaginal Delivery: A Randomized Clinical Trial |
| title_fullStr | Ketamine versus Tramadol for Analgesia in Spontaneous Vaginal Delivery: A Randomized Clinical Trial |
| title_full_unstemmed | Ketamine versus Tramadol for Analgesia in Spontaneous Vaginal Delivery: A Randomized Clinical Trial |
| title_short | Ketamine versus Tramadol for Analgesia in Spontaneous Vaginal Delivery: A Randomized Clinical Trial |
| title_sort | ketamine versus tramadol for analgesia in spontaneous vaginal delivery a randomized clinical trial |
| topic | ketamine tramadol analgesia spontaneous vaginal delivery |
| url | https://ijma.journals.ekb.eg/article_316791_b2812e695938784f2e6baec4a30fd931.pdf |
| work_keys_str_mv | AT khaledelsheshtawy ketamineversustramadolforanalgesiainspontaneousvaginaldeliveryarandomizedclinicaltrial |