ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage

ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage

NuRD (nucleosome remodeling and histone deacetylase) is a versatile multi-protein complex with roles in transcription regulation and the DNA damage response. Here, we show that ZMYND8 bridges NuRD to a number of putative DNA-binding zinc finger proteins. The MYND domain of ZMYND8 directly interacts...

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Bibliographic Details
Main Authors: Cornelia G. Spruijt, Martijn S. Luijsterburg, Roberta Menafra, Rik G.H. Lindeboom, Pascal W.T.C. Jansen, Raghu Ram Edupuganti, Marijke P. Baltissen, Wouter W. Wiegant, Moritz C. Voelker-Albert, Filomena Matarese, Anneloes Mensinga, Ina Poser, Harmjan R. Vos, Hendrik G. Stunnenberg, Haico van Attikum, Michiel Vermeulen
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
NuRD
ZMYND8
interaction proteomics
next-generation sequencing
gene expression
DNA damage
chromatin
GATAD2A
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312761

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