Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments
Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory disease of the intestine that can be classified as ulcerative colitis (UC) and Crohn’s disease (CD). Currently, the incidence of IBD is still increasing in developing countries. However, current treatments for IBD have limitati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/4/1031 |
| _version_ | 1797618887789903872 |
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| author | Yaxi Zhou Diandian Wang Wenjie Yan |
| author_facet | Yaxi Zhou Diandian Wang Wenjie Yan |
| author_sort | Yaxi Zhou |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory disease of the intestine that can be classified as ulcerative colitis (UC) and Crohn’s disease (CD). Currently, the incidence of IBD is still increasing in developing countries. However, current treatments for IBD have limitations and do not fully meet the needs of patients. There is a growing demand for new, safe, and highly effective alternative drugs for IBD patients. Natural products (NPs) are used in drug development and disease treatment because of their broad biological activity, low toxicity, and low side effects. Numerous studies have shown that some NPs have strong therapeutic effects on IBD. In this paper, we first reviewed the pathogenesis of IBD as well as current therapeutic approaches and drugs. Further, we summarized the therapeutic effects of 170 different sources of NPs on IBD and generalized their modes of action and therapeutic effects. Finally, we analyzed the potential mechanisms of NPs for the treatment of IBD. The aim of our review is to provide a systematic and credible summary, thus supporting the research on NPs for the treatment of IBD and providing a theoretical basis for the development and application of NPs in drugs and functional foods. |
| first_indexed | 2024-03-11T08:18:57Z |
| format | Article |
| id | doaj.art-6b12ed68e58d4b8eaba73b6a5a921aaf |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T08:18:57Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6b12ed68e58d4b8eaba73b6a5a921aaf2023-11-16T22:32:17ZengMDPI AGNutrients2072-66432023-02-01154103110.3390/nu15041031Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal ExperimentsYaxi Zhou0Diandian Wang1Wenjie Yan2College of Biochemical Engineering, Beijing Union University, Beijing 100023, ChinaCollege of Biochemical Engineering, Beijing Union University, Beijing 100023, ChinaCollege of Biochemical Engineering, Beijing Union University, Beijing 100023, ChinaInflammatory bowel disease (IBD) is a chronic, non-specific inflammatory disease of the intestine that can be classified as ulcerative colitis (UC) and Crohn’s disease (CD). Currently, the incidence of IBD is still increasing in developing countries. However, current treatments for IBD have limitations and do not fully meet the needs of patients. There is a growing demand for new, safe, and highly effective alternative drugs for IBD patients. Natural products (NPs) are used in drug development and disease treatment because of their broad biological activity, low toxicity, and low side effects. Numerous studies have shown that some NPs have strong therapeutic effects on IBD. In this paper, we first reviewed the pathogenesis of IBD as well as current therapeutic approaches and drugs. Further, we summarized the therapeutic effects of 170 different sources of NPs on IBD and generalized their modes of action and therapeutic effects. Finally, we analyzed the potential mechanisms of NPs for the treatment of IBD. The aim of our review is to provide a systematic and credible summary, thus supporting the research on NPs for the treatment of IBD and providing a theoretical basis for the development and application of NPs in drugs and functional foods.https://www.mdpi.com/2072-6643/15/4/1031natural productsinflammatory bowel diseasetherapeutic agentsmechanisms of action |
| spellingShingle | Yaxi Zhou Diandian Wang Wenjie Yan Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments Nutrients natural products inflammatory bowel disease therapeutic agents mechanisms of action |
| title | Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments |
| title_full | Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments |
| title_fullStr | Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments |
| title_full_unstemmed | Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments |
| title_short | Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments |
| title_sort | treatment effects of natural products on inflammatory bowel disease in vivo and their mechanisms based on animal experiments |
| topic | natural products inflammatory bowel disease therapeutic agents mechanisms of action |
| url | https://www.mdpi.com/2072-6643/15/4/1031 |
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