Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis
(1) Background: Obesity and diabetes continue to reach epidemic levels in the population with major health impacts that include a significantly increased risk of coronary atherosclerosis. The imbalance of trace elements in the body caused by nutritional factors can lead to the progression of coronar...
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MDPI AG
2022-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/2/319 |
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| author | Heyu Meng Yueying Wang Jianjun Ruan Yanqiu Chen Xue Wang Fengfeng Zhou Fanbo Meng |
| author_facet | Heyu Meng Yueying Wang Jianjun Ruan Yanqiu Chen Xue Wang Fengfeng Zhou Fanbo Meng |
| author_sort | Heyu Meng |
| collection | DOAJ |
| description | (1) Background: Obesity and diabetes continue to reach epidemic levels in the population with major health impacts that include a significantly increased risk of coronary atherosclerosis. The imbalance of trace elements in the body caused by nutritional factors can lead to the progression of coronary atherosclerosis. (2) Methods: We measured the concentrations of sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), Zinc (Zn), and iron (Fe) in peripheral blood samples from 4243 patients and performed baseline analysis and propensity matching of the patient datasets. The patients were grouped into acute myocardial infarction (AMI, 702 patients) and stable coronary heart disease (SCAD1, 253 patients) groups. Both of these groups were included in the AS that had a total of 1955 patients. The control group consisted of 2288 patients. The plasma concentrations of calcium, magnesium, and iron were measured using a colorimetric method. For comparison, 15 external quality assessment (EQA) samples were selected from the Clinical Laboratory Center of the Ministry of Health of China. SPSS software was used for statistical analysis. The average values and deviations of all of the indicators in each group were calculated, and a <i>p</i>-value threshold of <0.05 was used to indicate statistical significance. (3) Results: The iron ion concentrations of the acute myocardial infarction (AMI) group were significantly lower than the control group (<i>p</i> < 0.05, AUC = 0.724, AUC = 0.702), irrespective of tendency matching. Compared to the data from the stable coronary artery disease (SCAD) group, the concentration of iron ions in the acute myocardial infarction group was significantly lower (<i>p</i> < 0.05, AUC = 0.710, AUC = 0.682). Furthermore, the iron ion concentrations in the (AMI + SCAD) group were significantly lower (<i>p</i> < 0.05) than in the control group. (4) Conclusions: The data presented in this study strongly indicate that the concentration of iron ions in the peripheral blood is related to coronary atherosclerosis. Decreases in the levels of iron ions in the peripheral blood can be used as a predictive biomarker of coronary atherosclerosis. |
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| series | Nutrients |
| spelling | doaj.art-6b133939c5894c029676b0a8ea3227802023-11-23T14:57:31ZengMDPI AGNutrients2072-66432022-01-0114231910.3390/nu14020319Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary AtherosclerosisHeyu Meng0Yueying Wang1Jianjun Ruan2Yanqiu Chen3Xue Wang4Fengfeng Zhou5Fanbo Meng6Jilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis (Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute), Jilin University, Changchun 130033, ChinaCancer Systems Biology Center, Jilin University, Changchun 130033, ChinaJilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis (Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute), Jilin University, Changchun 130033, ChinaJilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis (Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute), Jilin University, Changchun 130033, ChinaJilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis (Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute), Jilin University, Changchun 130033, ChinaCancer Systems Biology Center, Jilin University, Changchun 130033, ChinaJilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis (Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute), Jilin University, Changchun 130033, China(1) Background: Obesity and diabetes continue to reach epidemic levels in the population with major health impacts that include a significantly increased risk of coronary atherosclerosis. The imbalance of trace elements in the body caused by nutritional factors can lead to the progression of coronary atherosclerosis. (2) Methods: We measured the concentrations of sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), Zinc (Zn), and iron (Fe) in peripheral blood samples from 4243 patients and performed baseline analysis and propensity matching of the patient datasets. The patients were grouped into acute myocardial infarction (AMI, 702 patients) and stable coronary heart disease (SCAD1, 253 patients) groups. Both of these groups were included in the AS that had a total of 1955 patients. The control group consisted of 2288 patients. The plasma concentrations of calcium, magnesium, and iron were measured using a colorimetric method. For comparison, 15 external quality assessment (EQA) samples were selected from the Clinical Laboratory Center of the Ministry of Health of China. SPSS software was used for statistical analysis. The average values and deviations of all of the indicators in each group were calculated, and a <i>p</i>-value threshold of <0.05 was used to indicate statistical significance. (3) Results: The iron ion concentrations of the acute myocardial infarction (AMI) group were significantly lower than the control group (<i>p</i> < 0.05, AUC = 0.724, AUC = 0.702), irrespective of tendency matching. Compared to the data from the stable coronary artery disease (SCAD) group, the concentration of iron ions in the acute myocardial infarction group was significantly lower (<i>p</i> < 0.05, AUC = 0.710, AUC = 0.682). Furthermore, the iron ion concentrations in the (AMI + SCAD) group were significantly lower (<i>p</i> < 0.05) than in the control group. (4) Conclusions: The data presented in this study strongly indicate that the concentration of iron ions in the peripheral blood is related to coronary atherosclerosis. Decreases in the levels of iron ions in the peripheral blood can be used as a predictive biomarker of coronary atherosclerosis.https://www.mdpi.com/2072-6643/14/2/319trace elementsiron ionscoronary atherosclerosisacute myocardial infarctionstable coronary artery disease |
| spellingShingle | Heyu Meng Yueying Wang Jianjun Ruan Yanqiu Chen Xue Wang Fengfeng Zhou Fanbo Meng Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis Nutrients trace elements iron ions coronary atherosclerosis acute myocardial infarction stable coronary artery disease |
| title | Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis |
| title_full | Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis |
| title_fullStr | Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis |
| title_full_unstemmed | Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis |
| title_short | Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis |
| title_sort | decreased iron ion concentrations in the peripheral blood correlate with coronary atherosclerosis |
| topic | trace elements iron ions coronary atherosclerosis acute myocardial infarction stable coronary artery disease |
| url | https://www.mdpi.com/2072-6643/14/2/319 |
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