Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease
Background. Bariatric surgery is the most effective treatment for morbid obesity and reduces the severity of nonalcoholic fatty liver disease (NAFLD) in the long term. Less is known about the effects of bariatric surgery on liver fat, inflammation, and fibrosis during the early stages following bari...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2023/4228321 |
| _version_ | 1797771632512598016 |
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| author | Hong Chang Tan Elizabeth Shumbayawonda Cayden Beyer Lionel Tim-Ee Cheng Albert Low Chin Hong Lim Alvin Eng Weng Hoong Chan Phong Ching Lee Mei Fang Tay Stella Kin Jason Pik Eu Chang Yong Mong Bee George Boon Bee Goh |
| author_facet | Hong Chang Tan Elizabeth Shumbayawonda Cayden Beyer Lionel Tim-Ee Cheng Albert Low Chin Hong Lim Alvin Eng Weng Hoong Chan Phong Ching Lee Mei Fang Tay Stella Kin Jason Pik Eu Chang Yong Mong Bee George Boon Bee Goh |
| author_sort | Hong Chang Tan |
| collection | DOAJ |
| description | Background. Bariatric surgery is the most effective treatment for morbid obesity and reduces the severity of nonalcoholic fatty liver disease (NAFLD) in the long term. Less is known about the effects of bariatric surgery on liver fat, inflammation, and fibrosis during the early stages following bariatric surgery. Aims. This exploratory study utilises advanced imaging methods to investigate NAFLD and fibrosis changes during the early metabolic transitional period following bariatric surgery. Methods. Nine participants with morbid obesity underwent sleeve gastrectomy. Multiparametric MRI (mpMRI) and magnetic resonance elastography (MRE) were performed at baseline, during the immediate (1 month), and late (6 months) postsurgery period. Liver fat was measured using proton density fat fraction (PDFF), disease activity using iron-correct T1 (cT1), and liver stiffness using MRE. Repeated measured ANOVA was used to assess longitudinal changes and Dunnett’s method for multiple comparisons. Results. All participants (Age 45.1±9.0 years, BMI 39.7±5.3 kg/m2) had elevated hepatic steatosis at baseline (PDFF >5%). In the immediate postsurgery period, PDFF decreased significantly from 14.1±7.4% to 8.9±4.4% (p=0.016) and cT1 from 826.9±80.6 ms to 768.4±50.9 ms (p=0.047). These improvements continued to the later postsurgery period. Bariatric surgery did not reduce liver stiffness measurements. Conclusion. Our findings support using MRI as a noninvasive tool to monitor NAFLD in patient with morbid obesity during the early stages following bariatric surgery. |
| first_indexed | 2024-03-12T21:40:24Z |
| format | Article |
| id | doaj.art-6b147e36c4be4d61b50fbef3e798d028 |
| institution | Directory Open Access Journal |
| issn | 1687-4196 |
| language | English |
| last_indexed | 2024-03-12T21:40:24Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj.art-6b147e36c4be4d61b50fbef3e798d0282023-07-27T00:00:05ZengHindawi LimitedInternational Journal of Biomedical Imaging1687-41962023-01-01202310.1155/2023/4228321Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver DiseaseHong Chang Tan0Elizabeth Shumbayawonda1Cayden Beyer2Lionel Tim-Ee Cheng3Albert Low4Chin Hong Lim5Alvin Eng6Weng Hoong Chan7Phong Ching Lee8Mei Fang Tay9Stella Kin10Jason Pik Eu Chang11Yong Mong Bee12George Boon Bee Goh13Singapore General HospitalPerspectum Ltd.Perspectum Ltd.Singapore General HospitalSingapore General HospitalSingapore General HospitalSingapore General HospitalSingapore General HospitalSingapore General HospitalSingapore General HospitalPerspectum Ltd.Singapore General HospitalSingapore General HospitalSingapore General HospitalBackground. Bariatric surgery is the most effective treatment for morbid obesity and reduces the severity of nonalcoholic fatty liver disease (NAFLD) in the long term. Less is known about the effects of bariatric surgery on liver fat, inflammation, and fibrosis during the early stages following bariatric surgery. Aims. This exploratory study utilises advanced imaging methods to investigate NAFLD and fibrosis changes during the early metabolic transitional period following bariatric surgery. Methods. Nine participants with morbid obesity underwent sleeve gastrectomy. Multiparametric MRI (mpMRI) and magnetic resonance elastography (MRE) were performed at baseline, during the immediate (1 month), and late (6 months) postsurgery period. Liver fat was measured using proton density fat fraction (PDFF), disease activity using iron-correct T1 (cT1), and liver stiffness using MRE. Repeated measured ANOVA was used to assess longitudinal changes and Dunnett’s method for multiple comparisons. Results. All participants (Age 45.1±9.0 years, BMI 39.7±5.3 kg/m2) had elevated hepatic steatosis at baseline (PDFF >5%). In the immediate postsurgery period, PDFF decreased significantly from 14.1±7.4% to 8.9±4.4% (p=0.016) and cT1 from 826.9±80.6 ms to 768.4±50.9 ms (p=0.047). These improvements continued to the later postsurgery period. Bariatric surgery did not reduce liver stiffness measurements. Conclusion. Our findings support using MRI as a noninvasive tool to monitor NAFLD in patient with morbid obesity during the early stages following bariatric surgery.http://dx.doi.org/10.1155/2023/4228321 |
| spellingShingle | Hong Chang Tan Elizabeth Shumbayawonda Cayden Beyer Lionel Tim-Ee Cheng Albert Low Chin Hong Lim Alvin Eng Weng Hoong Chan Phong Ching Lee Mei Fang Tay Stella Kin Jason Pik Eu Chang Yong Mong Bee George Boon Bee Goh Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease International Journal of Biomedical Imaging |
| title | Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease |
| title_full | Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease |
| title_fullStr | Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease |
| title_short | Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease |
| title_sort | multiparametric magnetic resonance imaging and magnetic resonance elastography to evaluate the early effects of bariatric surgery on nonalcoholic fatty liver disease |
| url | http://dx.doi.org/10.1155/2023/4228321 |
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