Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease
ObjectiveAccumulating experimental evidence has identified the beneficial effects of the anti-aging protein, serum soluble α-Klotho, on longevity, and the cardiovascular system. Although a previous study has revealed the predictive value of α-Klotho on total cardiovascular disease (CVD), the associa...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.899307/full |
| _version_ | 1811332080863281152 |
|---|---|
| author | Jun-Peng Xu Jun-Peng Xu Jun-Peng Xu Rui-Xiang Zeng Rui-Xiang Zeng Rui-Xiang Zeng Mu-Hua He Shan-Shan Lin Li-Heng Guo Li-Heng Guo Min-Zhou Zhang Min-Zhou Zhang |
| author_facet | Jun-Peng Xu Jun-Peng Xu Jun-Peng Xu Rui-Xiang Zeng Rui-Xiang Zeng Rui-Xiang Zeng Mu-Hua He Shan-Shan Lin Li-Heng Guo Li-Heng Guo Min-Zhou Zhang Min-Zhou Zhang |
| author_sort | Jun-Peng Xu |
| collection | DOAJ |
| description | ObjectiveAccumulating experimental evidence has identified the beneficial effects of the anti-aging protein, serum soluble α-Klotho, on longevity, and the cardiovascular system. Although a previous study has revealed the predictive value of α-Klotho on total cardiovascular disease (CVD), the associations between α-Klotho and specific CVDs, including congestive heart failure (CHF), coronary heart disease (CHD), myocardial infarction (MI), and stroke, remains to be fully elucidated in humans.MethodsFor 8,615 adults in the 2007 to 2016 National Health and Nutrition Examination Survey, stratified multivariable logistic regression models, restricted cubic spline curves, and subgroup analyses were used to evaluate the associations between α-Klotho and the four specific CVDs.ResultsIn the quartile analyses, compared to those in the highest quartile, participants in the lowest level of α-Klotho were significantly associated with CHF [odds ratio (OR) = 1.46, 95% CI: 1.09–1.97] and MI (1.33, 1.02–1.74), which was not the case for CHD (1.12, 0.91–1.38) or stroke (0.96, 0.73–1.25). Each unit increment in the ln-transformed α-Klotho concentrations was only positively associated with a 38 and 24% reduction in the prevalence of CHF and MI, respectively. Restricted cubic spline curves indicated that the α-Klotho was correlated with CHF and MI in linear-inverse relationships.ConclusionThe present findings suggested that the serum soluble α-Klotho is significantly associated with the prevalence of CHF and MI. To better determine whether α-Klotho is a specific biomarker of CVD, particularly for CHD and stroke, further research in humans is needed. |
| first_indexed | 2024-04-13T16:30:33Z |
| format | Article |
| id | doaj.art-6b1581ae7e244ec6b30166f314fc95f4 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-13T16:30:33Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-6b1581ae7e244ec6b30166f314fc95f42022-12-22T02:39:35ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-06-01910.3389/fcvm.2022.899307899307Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular DiseaseJun-Peng Xu0Jun-Peng Xu1Jun-Peng Xu2Rui-Xiang Zeng3Rui-Xiang Zeng4Rui-Xiang Zeng5Mu-Hua He6Shan-Shan Lin7Li-Heng Guo8Li-Heng Guo9Min-Zhou Zhang10Min-Zhou Zhang11The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaSchool of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaObjectiveAccumulating experimental evidence has identified the beneficial effects of the anti-aging protein, serum soluble α-Klotho, on longevity, and the cardiovascular system. Although a previous study has revealed the predictive value of α-Klotho on total cardiovascular disease (CVD), the associations between α-Klotho and specific CVDs, including congestive heart failure (CHF), coronary heart disease (CHD), myocardial infarction (MI), and stroke, remains to be fully elucidated in humans.MethodsFor 8,615 adults in the 2007 to 2016 National Health and Nutrition Examination Survey, stratified multivariable logistic regression models, restricted cubic spline curves, and subgroup analyses were used to evaluate the associations between α-Klotho and the four specific CVDs.ResultsIn the quartile analyses, compared to those in the highest quartile, participants in the lowest level of α-Klotho were significantly associated with CHF [odds ratio (OR) = 1.46, 95% CI: 1.09–1.97] and MI (1.33, 1.02–1.74), which was not the case for CHD (1.12, 0.91–1.38) or stroke (0.96, 0.73–1.25). Each unit increment in the ln-transformed α-Klotho concentrations was only positively associated with a 38 and 24% reduction in the prevalence of CHF and MI, respectively. Restricted cubic spline curves indicated that the α-Klotho was correlated with CHF and MI in linear-inverse relationships.ConclusionThe present findings suggested that the serum soluble α-Klotho is significantly associated with the prevalence of CHF and MI. To better determine whether α-Klotho is a specific biomarker of CVD, particularly for CHD and stroke, further research in humans is needed.https://www.frontiersin.org/articles/10.3389/fcvm.2022.899307/fullagingbiomarkerKlothocardiovascular diseaseNational Health and Nutrition Examination Survey (NHANES) |
| spellingShingle | Jun-Peng Xu Jun-Peng Xu Jun-Peng Xu Rui-Xiang Zeng Rui-Xiang Zeng Rui-Xiang Zeng Mu-Hua He Shan-Shan Lin Li-Heng Guo Li-Heng Guo Min-Zhou Zhang Min-Zhou Zhang Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease Frontiers in Cardiovascular Medicine aging biomarker Klotho cardiovascular disease National Health and Nutrition Examination Survey (NHANES) |
| title | Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease |
| title_full | Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease |
| title_fullStr | Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease |
| title_full_unstemmed | Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease |
| title_short | Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease |
| title_sort | associations between serum soluble α klotho and the prevalence of specific cardiovascular disease |
| topic | aging biomarker Klotho cardiovascular disease National Health and Nutrition Examination Survey (NHANES) |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.899307/full |
| work_keys_str_mv | AT junpengxu associationsbetweenserumsolubleaklothoandtheprevalenceofspecificcardiovasculardisease AT junpengxu associationsbetweenserumsolubleaklothoandtheprevalenceofspecificcardiovasculardisease AT junpengxu associationsbetweenserumsolubleaklothoandtheprevalenceofspecificcardiovasculardisease AT ruixiangzeng associationsbetweenserumsolubleaklothoandtheprevalenceofspecificcardiovasculardisease AT ruixiangzeng associationsbetweenserumsolubleaklothoandtheprevalenceofspecificcardiovasculardisease AT ruixiangzeng associationsbetweenserumsolubleaklothoandtheprevalenceofspecificcardiovasculardisease AT muhuahe associationsbetweenserumsolubleaklothoandtheprevalenceofspecificcardiovasculardisease AT shanshanlin associationsbetweenserumsolubleaklothoandtheprevalenceofspecificcardiovasculardisease AT lihengguo associationsbetweenserumsolubleaklothoandtheprevalenceofspecificcardiovasculardisease AT lihengguo associationsbetweenserumsolubleaklothoandtheprevalenceofspecificcardiovasculardisease AT minzhouzhang associationsbetweenserumsolubleaklothoandtheprevalenceofspecificcardiovasculardisease AT minzhouzhang associationsbetweenserumsolubleaklothoandtheprevalenceofspecificcardiovasculardisease |