The Interplay Between TGF-β Signaling and Cell Metabolism
The transforming growth factor-β (TGF-β) signaling plays a critical role in the development and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many pathological conditions. Mounting evidence suggests that TGF-β signaling can actively alter metabolism in diverse cell ty...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.846723/full |
| _version_ | 1818695043492347904 |
|---|---|
| author | Huidong Liu Ye-Guang Chen |
| author_facet | Huidong Liu Ye-Guang Chen |
| author_sort | Huidong Liu |
| collection | DOAJ |
| description | The transforming growth factor-β (TGF-β) signaling plays a critical role in the development and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many pathological conditions. Mounting evidence suggests that TGF-β signaling can actively alter metabolism in diverse cell types. Furthermore, metabolic pathways, beyond simply regarded as biochemical reactions, are closely intertwined with signal transduction. Here, we discuss the role of TGF-β in glucose, lipid, amino acid, redox and polyamine metabolism with an emphasis on how TGF-β can act as a metabolic modulator and how metabolic changes can influence TGF-β signaling. We also describe how interplay between TGF-β signaling and cell metabolism regulates cellular homeostasis as well as the progression of multiple diseases, including cancer. |
| first_indexed | 2024-12-17T13:39:12Z |
| format | Article |
| id | doaj.art-6b159be8d708494a90614c5233018011 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-17T13:39:12Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-6b159be8d708494a90614c52330180112022-12-21T21:46:20ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-03-011010.3389/fcell.2022.846723846723The Interplay Between TGF-β Signaling and Cell MetabolismHuidong LiuYe-Guang ChenThe transforming growth factor-β (TGF-β) signaling plays a critical role in the development and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many pathological conditions. Mounting evidence suggests that TGF-β signaling can actively alter metabolism in diverse cell types. Furthermore, metabolic pathways, beyond simply regarded as biochemical reactions, are closely intertwined with signal transduction. Here, we discuss the role of TGF-β in glucose, lipid, amino acid, redox and polyamine metabolism with an emphasis on how TGF-β can act as a metabolic modulator and how metabolic changes can influence TGF-β signaling. We also describe how interplay between TGF-β signaling and cell metabolism regulates cellular homeostasis as well as the progression of multiple diseases, including cancer.https://www.frontiersin.org/articles/10.3389/fcell.2022.846723/fullTGF-β signalingSmadglucose metabolismlipid metabolismamino acid metabolism |
| spellingShingle | Huidong Liu Ye-Guang Chen The Interplay Between TGF-β Signaling and Cell Metabolism Frontiers in Cell and Developmental Biology TGF-β signaling Smad glucose metabolism lipid metabolism amino acid metabolism |
| title | The Interplay Between TGF-β Signaling and Cell Metabolism |
| title_full | The Interplay Between TGF-β Signaling and Cell Metabolism |
| title_fullStr | The Interplay Between TGF-β Signaling and Cell Metabolism |
| title_full_unstemmed | The Interplay Between TGF-β Signaling and Cell Metabolism |
| title_short | The Interplay Between TGF-β Signaling and Cell Metabolism |
| title_sort | interplay between tgf β signaling and cell metabolism |
| topic | TGF-β signaling Smad glucose metabolism lipid metabolism amino acid metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.846723/full |
| work_keys_str_mv | AT huidongliu theinterplaybetweentgfbsignalingandcellmetabolism AT yeguangchen theinterplaybetweentgfbsignalingandcellmetabolism AT huidongliu interplaybetweentgfbsignalingandcellmetabolism AT yeguangchen interplaybetweentgfbsignalingandcellmetabolism |